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UniProtKB - P83940 (ELOC_MOUSE)

Entry version 157 (25 May 2022)
Sequence version 1 (07 Jun 2004)
Previous versions | rss
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Protein

Elongin-C

Gene

Eloc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).

In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226).

By similarity2 Publications

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-MMU-75955, RNA Polymerase II Transcription Elongation
R-MMU-8951664, Neddylation
R-MMU-9705462, Inactivation of CSF3 (G-CSF) signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongin-C
Short name:
EloC
Alternative name(s):
Elongin 15 kDa subunit
RNA polymerase II transcription factor SIII subunit C
SIII p15
Stromal membrane-associated protein SMAP1B homolog
Transcription elongation factor B polypeptide 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ElocImported
Synonyms:Tceb1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915173, Eloc

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000079658

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001872591 – 112Elongin-CAdd BLAST112

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P83940

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P83940

MaxQB - The MaxQuant DataBase

More...MaxQBi		P83940

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P83940

PeptideAtlas

More...PeptideAtlasi		P83940

PRoteomics IDEntifications database

More...PRIDEi		P83940

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		275452

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P83940

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P83940

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000079658, Expressed in primary oocyte and 329 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P83940, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (PubMed:27863225, PubMed:27863226). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either ASB2, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:10051596, PubMed:11384984, PubMed:9869640). The elongin BC complex is part of a complex with VHL and hydroxylated HIF1A.

Part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 and Elongin BC.

Part of an E3 ubiquitin-protein ligase complex including ZER1, CUL2 and Elongin BC.

Interacts with VHL.

Interacts with TMF1.

Interacts with SPSB1.

Interacts with SPSB1.

Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.

Interacts with NOS2 in the presence of SPSB1 or SPSB2 or SPSB4 (By similarity).

By similarity6 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212537, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P83940

Database of interacting proteins

More...DIPi		DIP-42814N

Protein interaction database and analysis system

More...IntActi		P83940, 19 interactors

Molecular INTeraction database

More...MINTi		P83940

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000140422

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P83940, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P83940

Biological Magnetic Resonance Data Bank

More...BMRBi		P83940

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P83940

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P83940

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3473, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_130038_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P83940

Identification of Orthologs from Complete Genome Data

More...OMAi		VCEYLYY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P83940

TreeFam database of animal gene trees

More...TreeFami		TF300233

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.710.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50219

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039948, ELC1
IPR001232, SKP1-like
IPR011333, SKP1/BTB/POZ_sf
IPR016073, Skp1_comp_POZ

The PANTHER Classification System

More...PANTHERi		PTHR20648, PTHR20648, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03931, Skp1_POZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00512, Skp1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P83940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG 
        60         70         80         90        100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA 
       110 
LELLMAANFL DC
Length:112
Mass (Da):12,473
Last modified:June 7, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98D88696E883538B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNT1A0A087WNT1_MOUSE
Elongin-C
Eloc Tceb1
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQE6A0A087WQE6_MOUSE
Elongin-C
Eloc Tceb1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPE4A0A087WPE4_MOUSE
Elongin-C
Eloc Tceb1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK013089 mRNA Translation: BAB28641.1
AK011757 mRNA Translation: BAB27825.1
AK011958 mRNA Translation: BAB27939.1
AK012909 mRNA Translation: BAB28546.1
AK039746 mRNA Translation: BAC30437.1
BC009104 mRNA Translation: AAH09104.1
BC028545 mRNA Translation: AAH28545.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35517.1

NCBI Reference Sequences

More...RefSeqi		NP_001297399.1, NM_001310470.1
NP_080732.1, NM_026456.4
XP_006495624.1, XM_006495561.2
XP_006495625.1, XM_006495562.1
XP_006495626.1, XM_006495563.3
XP_006495627.1, XM_006495564.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000115352; ENSMUSP00000111009; ENSMUSG00000079658
ENSMUST00000185771; ENSMUSP00000139675; ENSMUSG00000079658
ENSMUST00000186948; ENSMUSP00000140962; ENSMUSG00000079658
ENSMUST00000188641; ENSMUSP00000140422; ENSMUSG00000079658

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67923

UCSC genome browser

More...UCSCi		uc007ajv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013089 mRNA Translation: BAB28641.1
AK011757 mRNA Translation: BAB27825.1
AK011958 mRNA Translation: BAB27939.1
AK012909 mRNA Translation: BAB28546.1
AK039746 mRNA Translation: BAC30437.1
BC009104 mRNA Translation: AAH09104.1
BC028545 mRNA Translation: AAH28545.1
CCDSiCCDS35517.1
RefSeqiNP_001297399.1, NM_001310470.1
NP_080732.1, NM_026456.4
XP_006495624.1, XM_006495561.2
XP_006495625.1, XM_006495562.1
XP_006495626.1, XM_006495563.3
XP_006495627.1, XM_006495564.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FNJX-ray1.80C17-112[»]
2JZ3NMR-C17-112[»]
4JGHX-ray3.00C17-112[»]
AlphaFoldDBiP83940
BMRBiP83940
SMRiP83940
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi212537, 39 interactors
CORUMiP83940
DIPiDIP-42814N
IntActiP83940, 19 interactors
MINTiP83940
STRINGi10090.ENSMUSP00000140422

PTM databases

iPTMnetiP83940
PhosphoSitePlusiP83940

Proteomic databases

EPDiP83940
jPOSTiP83940
MaxQBiP83940
PaxDbiP83940
PeptideAtlasiP83940
PRIDEiP83940
ProteomicsDBi275452

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12329, 256 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		67923

Genome annotation databases

EnsembliENSMUST00000115352; ENSMUSP00000111009; ENSMUSG00000079658
ENSMUST00000185771; ENSMUSP00000139675; ENSMUSG00000079658
ENSMUST00000186948; ENSMUSP00000140962; ENSMUSG00000079658
ENSMUST00000188641; ENSMUSP00000140422; ENSMUSG00000079658
GeneIDi67923
KEGGimmu:67923
UCSCiuc007ajv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6921
MGIiMGI:1915173, Eloc
VEuPathDBiHostDB:ENSMUSG00000079658

Phylogenomic databases

eggNOGiKOG3473, Eukaryota
GeneTreeiENSGT00390000011717
HOGENOMiCLU_130038_0_2_1
InParanoidiP83940
OMAiVCEYLYY
PhylomeDBiP83940
TreeFamiTF300233

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-MMU-75955, RNA Polymerase II Transcription Elongation
R-MMU-8951664, Neddylation
R-MMU-9705462, Inactivation of CSF3 (G-CSF) signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67923, 26 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tceb1, mouse
EvolutionaryTraceiP83940

Protein Ontology

More...PROi		PR:P83940
RNActiP83940, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000079658, Expressed in primary oocyte and 329 other tissues
GenevisibleiP83940, MM

Family and domain databases

Gene3Di3.30.710.10, 1 hit
IDEALiIID50219
InterProiView protein in InterPro
IPR039948, ELC1
IPR001232, SKP1-like
IPR011333, SKP1/BTB/POZ_sf
IPR016073, Skp1_comp_POZ
PANTHERiPTHR20648, PTHR20648, 1 hit
PfamiView protein in Pfam
PF03931, Skp1_POZ, 1 hit
SMARTiView protein in SMART
SM00512, Skp1, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELOC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83940
Secondary accession number(s): Q63182
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 25, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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