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Protein

Chromobox protein homolog 1

Gene

Cbx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21Histone H3K9me21
Binding sitei23Histone H3A71
Binding sitei40Histone H3A71
Binding sitei42Histone H3A71
Binding sitei42Histone H3K9me21
Binding sitei45Histone H3K9me21
Binding sitei58Histone H3A71
Binding sitei60Histone H3A71
Binding sitei125PxVxL motif1
Binding sitei126PxVxL motif1
Binding sitei135PxVxL motif1
Binding sitei146PxVxL motif1
Binding sitei163PxVxL motif1
Binding sitei167PxVxL motif1
Binding sitei168PxVxL motif1
Binding sitei170PxVxL motif1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 1
Alternative name(s):
Heterochromatin protein 1 homolog beta
Short name:
HP1 beta
Heterochromatin protein p25
M31
Modifier 1 protein
Gene namesi
Name:Cbx1
Synonyms:Cbx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105369 Cbx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23V → M: Abolishes interaction with SUV39H1. 1 Publication1
Mutagenesisi26V → R: Abolishes interaction with SUV39H1. 1 Publication1
Mutagenesisi161I → E: Abolishes homodimer formation. 1 Publication1
Mutagenesisi164Y → E: Abolishes homodimer formation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802001 – 185Chromobox protein homolog 1Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei89PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei175PhosphoserineBy similarity1

Post-translational modificationi

Not phosphorylated.By similarity
Ubiquitinated.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP83917
MaxQBiP83917
PaxDbiP83917
PeptideAtlasiP83917
PRIDEiP83917

2D gel databases

REPRODUCTION-2DPAGEiIPI00129466

PTM databases

iPTMnetiP83917
PhosphoSitePlusiP83917

Expressioni

Tissue specificityi

In all adult and embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000018666 Expressed in 327 organ(s), highest expression level in vestibular organ
CleanExiMM_CBX1
ExpressionAtlasiP83917 baseline and differential
GenevisibleiP83917 MM

Interactioni

Subunit structurei

Homodimer (PubMed:10747027). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain (PubMed:8978696, PubMed:10562550, PubMed:10747027). Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (PubMed:11571267). Interacts with SUV39H1, SETDB1, KMT5B and KMT5C (PubMed:10202156, PubMed:15145825). Interacts with PRDM6 (PubMed:16537907). Interacts with POGZ (By similarity). Interacts with CHAMP1 (By similarity). Interacts with ASXL1 (By similarity). Interacts with INCENP (By similarity). Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1 (By similarity). Interacts with LRIF1 (via PxVxL motif) (By similarity).By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198534, 163 interactors
DIPiDIP-30892N
IntActiP83917, 157 interactors
MINTiP83917
STRINGi10090.ENSMUSP00000091475

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP83917
SMRiP83917
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83917

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 79Chromo 1PROSITE-ProRule annotationAdd BLAST59
Domaini117 – 175Chromo 2; shadow subtypePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KDV3 Eukaryota
ENOG4111H4A LUCA
GeneTreeiENSGT00510000046310
HOGENOMiHOG000220852
HOVERGENiHBG000400
InParanoidiP83917
KOiK11585
OMAiQTWEPED
OrthoDBiEOG091G0RBS
PhylomeDBiP83917
TreeFamiTF350503

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR008251 Chromo_shadow_dom
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF01393 Chromo_shadow, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00300 ChSh, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P83917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN
60 70 80 90 100
TWEPEENLDC PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP
110 120 130 140 150
KKKKEESEKP RGFARGLEPE RIIGATDSSG ELMFLMKWKN SDEADLVPAK
160 170 180
EANVKCPQVV ISFYEERLTW HSYPSEDDDK KDDKN
Length:185
Mass (Da):21,418
Last modified:June 7, 2004 - v1
Checksum:iBE687AF9C66E48E3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TPM0Q7TPM0_MOUSE
Cbx1 protein
Cbx1
138Annotation score:
Q9CYJ8Q9CYJ8_MOUSE
Chromobox homolog 1 (Drosophila HP1...
Cbx1 mCG_13242
150Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56690 mRNA Translation: CAA40018.1
AK014215 mRNA Translation: BAB29211.1
CCDSiCCDS25303.1
PIRiS26847
RefSeqiNP_031648.1, NM_007622.3
XP_006532162.1, XM_006532099.2
XP_006532163.1, XM_006532100.2
XP_011247006.1, XM_011248704.2
XP_017169731.1, XM_017314242.1
UniGeneiMm.29055

Genome annotation databases

EnsembliENSMUST00000093943; ENSMUSP00000091475; ENSMUSG00000018666
GeneIDi12412
KEGGimmu:12412
UCSCiuc007lck.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56690 mRNA Translation: CAA40018.1
AK014215 mRNA Translation: BAB29211.1
CCDSiCCDS25303.1
PIRiS26847
RefSeqiNP_031648.1, NM_007622.3
XP_006532162.1, XM_006532099.2
XP_006532163.1, XM_006532100.2
XP_011247006.1, XM_011248704.2
XP_017169731.1, XM_017314242.1
UniGeneiMm.29055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP0NMR-A10-80[»]
1DZ1NMR-A/B104-171[»]
1GUWNMR-A10-80[»]
1S4ZNMR-A/B104-176[»]
ProteinModelPortaliP83917
SMRiP83917
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198534, 163 interactors
DIPiDIP-30892N
IntActiP83917, 157 interactors
MINTiP83917
STRINGi10090.ENSMUSP00000091475

PTM databases

iPTMnetiP83917
PhosphoSitePlusiP83917

2D gel databases

REPRODUCTION-2DPAGEiIPI00129466

Proteomic databases

EPDiP83917
MaxQBiP83917
PaxDbiP83917
PeptideAtlasiP83917
PRIDEiP83917

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093943; ENSMUSP00000091475; ENSMUSG00000018666
GeneIDi12412
KEGGimmu:12412
UCSCiuc007lck.1 mouse

Organism-specific databases

CTDi10951
MGIiMGI:105369 Cbx1

Phylogenomic databases

eggNOGiENOG410KDV3 Eukaryota
ENOG4111H4A LUCA
GeneTreeiENSGT00510000046310
HOGENOMiHOG000220852
HOVERGENiHBG000400
InParanoidiP83917
KOiK11585
OMAiQTWEPED
OrthoDBiEOG091G0RBS
PhylomeDBiP83917
TreeFamiTF350503

Miscellaneous databases

ChiTaRSiCbx1 mouse
EvolutionaryTraceiP83917
PROiPR:P83917
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018666 Expressed in 327 organ(s), highest expression level in vestibular organ
CleanExiMM_CBX1
ExpressionAtlasiP83917 baseline and differential
GenevisibleiP83917 MM

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR008251 Chromo_shadow_dom
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF01393 Chromo_shadow, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00300 ChSh, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCBX1_MOUSE
AccessioniPrimary (citable) accession number: P83917
Secondary accession number(s): P23197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 10, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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