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Protein

Tubulin gamma-1 chain

Gene

Tubg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: GO_Central
  • identical protein binding Source: MGI
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-1 chain
Alternative name(s):
Gamma-1-tubulin
Gamma-tubulin complex component 1
Short name:
GCP-1
Gene namesi
Name:Tubg1
Synonyms:Tubg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101834 Tubg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131S → A: Weak effect possibly due to low expression of this mutant. 1 Publication1
Mutagenesisi131S → D: Phosphomimetic mutant that lead to increased centrosome number. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484661 – 451Tubulin gamma-1 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine; by BRSK11 Publication1

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP83887
PaxDbiP83887
PeptideAtlasiP83887
PRIDEiP83887

PTM databases

iPTMnetiP83887
PhosphoSitePlusiP83887

Expressioni

Gene expression databases

BgeeiENSMUSG00000035198 Expressed in 272 organ(s), highest expression level in neocortex
CleanExiMM_TUBG1
ExpressionAtlasiP83887 baseline and differential
GenevisibleiP83887 MM

Interactioni

Subunit structurei

Interacts with TUBGCP2 and TUBGCP3 (By similarity). Interacts with B9D2 (PubMed:18287022). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2 (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with SAS6 and NUP62 at the centrosome (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222149, 107 interactors
IntActiP83887, 105 interactors
MINTiP83887
STRINGi10090.ENSMUSP00000048036

Structurei

3D structure databases

ProteinModelPortaliP83887
SMRiP83887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiP83887
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG091G08A9
PhylomeDBiP83887
TreeFamiTF300477

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

P83887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS SYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NLIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQFDKLRK
410 420 430 440 450
REAFMEQFRK EDIFKDNFDE MDTSREIVQQ LIDEYHAATR PDYISWGTQE

Q
Length:451
Mass (Da):51,101
Last modified:May 10, 2004 - v1
Checksum:iA8F1068D12D0C88A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006581 mRNA Translation: AAH06581.1
CCDSiCCDS25451.1
RefSeqiNP_598785.1, NM_134024.2
UniGeneiMm.479145

Genome annotation databases

EnsembliENSMUST00000043680; ENSMUSP00000048036; ENSMUSG00000035198
GeneIDi103733
KEGGimmu:103733
UCSCiuc007lnk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006581 mRNA Translation: AAH06581.1
CCDSiCCDS25451.1
RefSeqiNP_598785.1, NM_134024.2
UniGeneiMm.479145

3D structure databases

ProteinModelPortaliP83887
SMRiP83887
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222149, 107 interactors
IntActiP83887, 105 interactors
MINTiP83887
STRINGi10090.ENSMUSP00000048036

PTM databases

iPTMnetiP83887
PhosphoSitePlusiP83887

Proteomic databases

EPDiP83887
PaxDbiP83887
PeptideAtlasiP83887
PRIDEiP83887

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043680; ENSMUSP00000048036; ENSMUSG00000035198
GeneIDi103733
KEGGimmu:103733
UCSCiuc007lnk.1 mouse

Organism-specific databases

CTDi7283
MGIiMGI:101834 Tubg1

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiP83887
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG091G08A9
PhylomeDBiP83887
TreeFamiTF300477

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiTubg1 mouse
PROiPR:P83887
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035198 Expressed in 272 organ(s), highest expression level in neocortex
CleanExiMM_TUBG1
ExpressionAtlasiP83887 baseline and differential
GenevisibleiP83887 MM

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBG1_MOUSE
AccessioniPrimary (citable) accession number: P83887
Secondary accession number(s): Q9Z310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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