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Protein

60S ribosomal protein L36a

Gene

RPL36A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36a
Alternative name(s):
60S ribosomal protein L44
Cell growth-inhibiting gene 15 protein
Cell migration-inducing gene 6 protein
Large ribosomal subunit protein eL421 Publication
Gene namesi
Name:RPL36A
Synonyms:RPL44
ORF Names:GIG15, MIG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000241343.9
HGNCiHGNC:10359 RPL36A
MIMi300902 gene
neXtProtiNX_P83881

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6173
OpenTargetsiENSG00000241343
PharmGKBiPA164742367

Polymorphism and mutation databases

DMDMi47117731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491171 – 10660S ribosomal protein L36aAdd BLAST106

Proteomic databases

EPDiP83881
MaxQBiP83881
PaxDbiP83881
PeptideAtlasiP83881
PRIDEiP83881
ProteomicsDBi57741
TopDownProteomicsiP83881

PTM databases

iPTMnetiP83881
PhosphoSitePlusiP83881
SwissPalmiP83881

Expressioni

Gene expression databases

BgeeiENSG00000241343 Expressed in 89 organ(s), highest expression level in right ovary
CleanExiHS_RPL36A
ExpressionAtlasiP83881 baseline and differential

Organism-specific databases

HPAiHPA077586

Interactioni

Protein-protein interaction databases

BioGridi112092, 42 interactors
CORUMiP83881
IntActiP83881, 17 interactors
MINTiP83881
STRINGi9606.ENSP00000404375

Structurei

3D structure databases

ProteinModelPortaliP83881
SMRiP83881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3464 Eukaryota
COG1631 LUCA
GeneTreeiENSGT00390000018085
HOGENOMiHOG000224989
HOVERGENiHBG056127
InParanoidiP83881
KOiK02929
PhylomeDBiP83881

Family and domain databases

InterProiView protein in InterPro
IPR000552 Ribosomal_L44e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR10369 PTHR10369, 1 hit
PfamiView protein in Pfam
PF00935 Ribosomal_L44, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002841 Ribosomal_L44e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01172 RIBOSOMAL_L44E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P83881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG
60 70 80 90 100
QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK

GQVIQF
Length:106
Mass (Da):12,441
Last modified:January 23, 2007 - v2
Checksum:iAE3308265D70BD26
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQN4J3KQN4_HUMAN
60S ribosomal protein L36a
RPL36A
142Annotation score:
H0Y5B4H0Y5B4_HUMAN
60S ribosomal protein L36a
RPL36A
112Annotation score:
H7BY91H7BY91_HUMAN
60S ribosomal protein L36a
RPL36A
70Annotation score:
R4GN19R4GN19_HUMAN
60S ribosomal protein L36a
RPL36A
25Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78027 Genomic DNA Translation: AAB64204.1
AY305871 mRNA Translation: AAQ95213.1
CR542198 mRNA Translation: CAG46995.1
AY927233 mRNA Translation: AAX08138.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02860.1
BC001781 mRNA Translation: AAH01781.1
BC031015 mRNA Translation: AAH31015.1
BC062219 mRNA Translation: AAH62219.1
BC070204 mRNA Translation: AAH70204.1
RefSeqiNP_066357.2, NM_021029.5
UniGeneiHs.432485
Hs.655348

Genome annotation databases

EnsembliENST00000553110; ENSP00000446503; ENSG00000241343
GeneIDi6173
KEGGihsa:6173
UCSCiuc065agx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78027 Genomic DNA Translation: AAB64204.1
AY305871 mRNA Translation: AAQ95213.1
CR542198 mRNA Translation: CAG46995.1
AY927233 mRNA Translation: AAX08138.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02860.1
BC001781 mRNA Translation: AAH01781.1
BC031015 mRNA Translation: AAH31015.1
BC062219 mRNA Translation: AAH62219.1
BC070204 mRNA Translation: AAH70204.1
RefSeqiNP_066357.2, NM_021029.5
UniGeneiHs.432485
Hs.655348

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lo1-106[»]
4V6Xelectron microscopy5.00Co1-106[»]
5AJ0electron microscopy3.50Ao1-106[»]
5LKSelectron microscopy3.60Lo1-106[»]
5T2Celectron microscopy3.60i1-106[»]
6EK0electron microscopy2.90Lo1-106[»]
ProteinModelPortaliP83881
SMRiP83881
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112092, 42 interactors
CORUMiP83881
IntActiP83881, 17 interactors
MINTiP83881
STRINGi9606.ENSP00000404375

PTM databases

iPTMnetiP83881
PhosphoSitePlusiP83881
SwissPalmiP83881

Polymorphism and mutation databases

DMDMi47117731

Proteomic databases

EPDiP83881
MaxQBiP83881
PaxDbiP83881
PeptideAtlasiP83881
PRIDEiP83881
ProteomicsDBi57741
TopDownProteomicsiP83881

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000553110; ENSP00000446503; ENSG00000241343
GeneIDi6173
KEGGihsa:6173
UCSCiuc065agx.1 human

Organism-specific databases

CTDi6173
DisGeNETi6173
EuPathDBiHostDB:ENSG00000241343.9
GeneCardsiRPL36A
H-InvDBiHIX0016927
HIX0056232
HGNCiHGNC:10359 RPL36A
HPAiHPA077586
MIMi300902 gene
neXtProtiNX_P83881
OpenTargetsiENSG00000241343
PharmGKBiPA164742367
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3464 Eukaryota
COG1631 LUCA
GeneTreeiENSGT00390000018085
HOGENOMiHOG000224989
HOVERGENiHBG056127
InParanoidiP83881
KOiK02929
PhylomeDBiP83881

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL36A human
GeneWikiiRPL36A
GenomeRNAii6173
PROiPR:P83881
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241343 Expressed in 89 organ(s), highest expression level in right ovary
CleanExiHS_RPL36A
ExpressionAtlasiP83881 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000552 Ribosomal_L44e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR10369 PTHR10369, 1 hit
PfamiView protein in Pfam
PF00935 Ribosomal_L44, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002841 Ribosomal_L44e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01172 RIBOSOMAL_L44E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL36A_HUMAN
AccessioniPrimary (citable) accession number: P83881
Secondary accession number(s): P09896
, P10661, Q08ES5, Q5J9I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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