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Protein

Thioredoxin-like protein 4A

Gene

Txnl4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4A
Alternative name(s):
DIM1 protein homolog
Spliceosomal U5 snRNP-specific 15 kDa protein
Thioredoxin-like U5 snRNP protein U5-15kD
Gene namesi
Name:Txnl4a
Synonyms:Dim1, Txnl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1351613 Txnl4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182881 – 142Thioredoxin-like protein 4AAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 79By similarity
Modified residuei132PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP83877
MaxQBiP83877
PaxDbiP83877
PeptideAtlasiP83877
PRIDEiP83877

PTM databases

iPTMnetiP83877
PhosphoSitePlusiP83877

Expressioni

Gene expression databases

BgeeiENSMUSG00000057130 Expressed in 184 organ(s), highest expression level in brain
CleanExiMM_TXNL4A
ExpressionAtlasiP83877 baseline and differential
GenevisibleiP83877 MM

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.By similarity

Protein-protein interaction databases

BioGridi205173, 1 interactor
IntActiP83877, 1 interactor
MINTiP83877
STRINGi10090.ENSMUSP00000115320

Structurei

3D structure databases

ProteinModelPortaliP83877
SMRiP83877
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOVERGENiHBG053996
InParanoidiP83877
KOiK12859
OMAiTMFFYRN
OrthoDBiEOG091G0QHA
PhylomeDBiP83877
TreeFamiTF313562

Family and domain databases

CDDicd02954 DIM1, 1 hit
InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P83877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYMLPHLHN GWQVDQAILS EEDRVVVIRF GHDWDPTCMK MDEVLYSIAE
60 70 80 90 100
KVKNFAVIYL VDITEVPDFN KMYELYDPCT VMFFFRNKHI MIDLGTGNNN
110 120 130 140
KINWAMEDKQ EMVDIIETVY RGARKGRGLV VSPKDYSTKY RY
Length:142
Mass (Da):16,786
Last modified:April 26, 2004 - v1
Checksum:iEDDDAD7ADAEE87F3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGE7F8WGE7_MOUSE
Thioredoxin-like protein 4A
Txnl4a
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004039 mRNA Translation: BAB23137.1
AK007331 mRNA Translation: BAB24966.1
AK148287 mRNA Translation: BAE28459.1
AK166497 mRNA Translation: BAE38809.1
BC031634 mRNA Translation: AAH31634.1
CCDSiCCDS29365.1
RefSeqiNP_079575.1, NM_025299.3
XP_006526550.1, XM_006526487.3
UniGeneiMm.172411

Genome annotation databases

EnsembliENSMUST00000145963; ENSMUSP00000115320; ENSMUSG00000057130
GeneIDi27366
KEGGimmu:27366
UCSCiuc008fso.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004039 mRNA Translation: BAB23137.1
AK007331 mRNA Translation: BAB24966.1
AK148287 mRNA Translation: BAE28459.1
AK166497 mRNA Translation: BAE38809.1
BC031634 mRNA Translation: AAH31634.1
CCDSiCCDS29365.1
RefSeqiNP_079575.1, NM_025299.3
XP_006526550.1, XM_006526487.3
UniGeneiMm.172411

3D structure databases

ProteinModelPortaliP83877
SMRiP83877
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205173, 1 interactor
IntActiP83877, 1 interactor
MINTiP83877
STRINGi10090.ENSMUSP00000115320

PTM databases

iPTMnetiP83877
PhosphoSitePlusiP83877

Proteomic databases

EPDiP83877
MaxQBiP83877
PaxDbiP83877
PeptideAtlasiP83877
PRIDEiP83877

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145963; ENSMUSP00000115320; ENSMUSG00000057130
GeneIDi27366
KEGGimmu:27366
UCSCiuc008fso.1 mouse

Organism-specific databases

CTDi10907
MGIiMGI:1351613 Txnl4a

Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOVERGENiHBG053996
InParanoidiP83877
KOiK12859
OMAiTMFFYRN
OrthoDBiEOG091G0QHA
PhylomeDBiP83877
TreeFamiTF313562

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

PROiPR:P83877
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057130 Expressed in 184 organ(s), highest expression level in brain
CleanExiMM_TXNL4A
ExpressionAtlasiP83877 baseline and differential
GenevisibleiP83877 MM

Family and domain databases

CDDicd02954 DIM1, 1 hit
InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXN4A_MOUSE
AccessioniPrimary (citable) accession number: P83877
Secondary accession number(s): O14834, Q3TLI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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