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Entry version 159 (26 Feb 2020)
Sequence version 1 (26 Apr 2004)
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Protein

Thioredoxin-like protein 4A

Gene

TXNL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).2 Publications1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thioredoxin-like protein 4A
Alternative name(s):
DIM1 protein homolog2 Publications
Spliceosomal U5 snRNP-specific 15 kDa protein1 Publication
Thioredoxin-like U5 snRNP protein U5-15kD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TXNL4A
Synonyms:DIM1, TXNL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30551 TXNL4A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611595 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P83876

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Burn-McKeown syndrome (BMKS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by choanal atresia, sensorineural deafness, cardiac defects, and typical craniofacial dysmorphism consisting of narrow palpebral fissures, coloboma of the lower eyelids, prominent nose with high nasal bridge, short philtrum, cleft lip and/or palate, and large and protruding ears. Intellectual development is normal.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38C → A: Viable when expressed in S.pombe. 1 Publication1

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
10907

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TXNL4A

MalaCards human disease database

More...
MalaCardsi
TXNL4A
MIMi608572 phenotype

Open Targets

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OpenTargetsi
ENSG00000141759

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1200 Choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937290

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P83876 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TXNL4A

Domain mapping of disease mutations (DMDM)

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DMDMi
46577662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002182871 – 142Thioredoxin-like protein 4AAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 792 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737).2 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P83876

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P83876

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P83876

MaxQB - The MaxQuant DataBase

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MaxQBi
P83876

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P83876

PeptideAtlas

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PeptideAtlasi
P83876

PRoteomics IDEntifications database

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PRIDEi
P83876

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57740

Consortium for Top Down Proteomics

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TopDownProteomicsi
P83876

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P83876

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P83876

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141759 Expressed in substantia nigra and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P83876 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P83876 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041324

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).

Component of the U5 snRNP complex (PubMed:10610776).

Component of the U4/U6-U5 tri-snRNP complex (PubMed:26912367). The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:26912367, PubMed:28781166). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:16723661, PubMed:26912367, PubMed:28781166). Directly interacts with CD2BP2 (PubMed:17467737, PubMed:24781215).

Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1 (PubMed:11054566).

Interacts with ERBB4 (PubMed:20858735).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116113, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P83876

Protein interaction database and analysis system

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IntActi
P83876, 30 interactors

Molecular INTeraction database

More...
MINTi
P83876

STRING: functional protein association networks

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STRINGi
9606.ENSP00000269601

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P83876 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P83876

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P83876

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3414 Eukaryota
ENOG4111FE6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000010779

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_117348_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P83876

KEGG Orthology (KO)

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KOi
K12859

Identification of Orthologs from Complete Genome Data

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OMAi
TMFFYRN

Database of Orthologous Groups

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OrthoDBi
1320693at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P83876

TreeFam database of animal gene trees

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TreeFami
TF313562

Family and domain databases

Conserved Domains Database

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CDDi
cd02954 DIM1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf

The PANTHER Classification System

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PANTHERi
PTHR12052 PTHR12052, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02966 DIM1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017199 mRNA_splic_U5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01410 DIM1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P83876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYMLPHLHN GWQVDQAILS EEDRVVVIRF GHDWDPTCMK MDEVLYSIAE
60 70 80 90 100
KVKNFAVIYL VDITEVPDFN KMYELYDPCT VMFFFRNKHI MIDLGTGNNN
110 120 130 140
KINWAMEDKQ EMVDIIETVY RGARKGRGLV VSPKDYSTKY RY
Length:142
Mass (Da):16,786
Last modified:April 26, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDDDAD7ADAEE87F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES07K7ES07_HUMAN
Thioredoxin-like protein 4A
TXNL4A
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O14835O14835_HUMAN
Dim1p homolog
TXNL4A hCG_16170
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESL1K7ESL1_HUMAN
Thioredoxin-like protein 4A
TXNL4A
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMX5K7EMX5_HUMAN
Thioredoxin-like protein 4A
TXNL4A
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJU2K7EJU2_HUMAN
Thioredoxin-like protein 4A
TXNL4A
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPA6K7EPA6_HUMAN
Thioredoxin-like protein 4A
TXNL4A
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF023611 mRNA Translation: AAB81950.1
AF146373 mRNA Translation: AAF17332.1
AK314901 mRNA Translation: BAG37415.1
CH471117 Genomic DNA Translation: EAW66640.1
BC001046 mRNA Translation: AAH01046.1
BC019272 mRNA Translation: AAH19272.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32852.1

NCBI Reference Sequences

More...
RefSeqi
NP_001290400.1, NM_001303471.2
NP_001292486.1, NM_001305557.1
NP_001292492.1, NM_001305563.1
NP_001292493.1, NM_001305564.1
NP_006692.1, NM_006701.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269601; ENSP00000269601; ENSG00000141759

Database of genes from NCBI RefSeq genomes

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GeneIDi
10907

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10907

UCSC genome browser

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UCSCi
uc002lnp.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023611 mRNA Translation: AAB81950.1
AF146373 mRNA Translation: AAF17332.1
AK314901 mRNA Translation: BAG37415.1
CH471117 Genomic DNA Translation: EAW66640.1
BC001046 mRNA Translation: AAH01046.1
BC019272 mRNA Translation: AAH19272.1
CCDSiCCDS32852.1
RefSeqiNP_001290400.1, NM_001303471.2
NP_001292486.1, NM_001305557.1
NP_001292492.1, NM_001305563.1
NP_001292493.1, NM_001305564.1
NP_006692.1, NM_006701.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQNNMR-A2-128[»]
1QGVX-ray1.40A1-142[»]
1SYXX-ray2.35A/C/E1-142[»]
3JCRelectron microscopy7.00E1-142[»]
4BWQX-ray2.10A/C/E/G4-137[»]
4BWSX-ray2.50A/D4-137[»]
4CDOX-ray2.50A/C4-137[»]
5O9Zelectron microscopy4.50J1-142[»]
6AH0electron microscopy5.70O1-142[»]
6AHDelectron microscopy3.80O1-142[»]
6QW6electron microscopy2.925D1-142[»]
6QX9electron microscopy3.285D1-142[»]
SMRiP83876
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116113, 39 interactors
CORUMiP83876
IntActiP83876, 30 interactors
MINTiP83876
STRINGi9606.ENSP00000269601

PTM databases

iPTMnetiP83876
PhosphoSitePlusiP83876

Polymorphism and mutation databases

BioMutaiTXNL4A
DMDMi46577662

Proteomic databases

EPDiP83876
jPOSTiP83876
MassIVEiP83876
MaxQBiP83876
PaxDbiP83876
PeptideAtlasiP83876
PRIDEiP83876
ProteomicsDBi57740
TopDownProteomicsiP83876

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10907

Genome annotation databases

EnsembliENST00000269601; ENSP00000269601; ENSG00000141759
GeneIDi10907
KEGGihsa:10907
UCSCiuc002lnp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10907
DisGeNETi10907

GeneCards: human genes, protein and diseases

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GeneCardsi
TXNL4A
GeneReviewsiTXNL4A
HGNCiHGNC:30551 TXNL4A
HPAiHPA041324
MalaCardsiTXNL4A
MIMi608572 phenotype
611595 gene
neXtProtiNX_P83876
OpenTargetsiENSG00000141759
Orphaneti1200 Choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome
PharmGKBiPA134937290

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3414 Eukaryota
ENOG4111FE6 LUCA
GeneTreeiENSGT00390000010779
HOGENOMiCLU_117348_0_0_1
InParanoidiP83876
KOiK12859
OMAiTMFFYRN
OrthoDBi1320693at2759
PhylomeDBiP83876
TreeFamiTF313562

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TXNL4A human
EvolutionaryTraceiP83876

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TXNL4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10907
PharosiP83876 Tbio

Protein Ontology

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PROi
PR:P83876
RNActiP83876 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141759 Expressed in substantia nigra and 231 other tissues
ExpressionAtlasiP83876 baseline and differential
GenevisibleiP83876 HS

Family and domain databases

CDDicd02954 DIM1, 1 hit
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR004123 Dim1
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12052 PTHR12052, 1 hit
PfamiView protein in Pfam
PF02966 DIM1, 1 hit
PIRSFiPIRSF017199 mRNA_splic_U5, 1 hit
SMARTiView protein in SMART
SM01410 DIM1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTXN4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83876
Secondary accession number(s): B2RC18, O14834
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: February 26, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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