UniProtKB - P83871 (PHF5A_RAT)
PHD finger-like domain-containing protein 5A
Phf5a
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 11 | Zinc 1By similarity | 1 | |
Metal bindingi | 23 | Zinc 2By similarity | 1 | |
Metal bindingi | 26 | Zinc 2By similarity | 1 | |
Metal bindingi | 30 | Zinc 3By similarity | 1 | |
Metal bindingi | 33 | Zinc 3By similarity | 1 | |
Metal bindingi | 46 | Zinc 1By similarity | 1 | |
Metal bindingi | 49 | Zinc 1By similarity | 1 | |
Metal bindingi | 58 | Zinc 2By similarity | 1 | |
Metal bindingi | 61 | Zinc 2By similarity | 1 | |
Metal bindingi | 72 | Zinc 3By similarity | 1 | |
Metal bindingi | 75 | Zinc 3By similarity | 1 | |
Metal bindingi | 85 | Zinc 1By similarity | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- RNA binding Source: RGD
- zinc ion binding Source: RGD
GO - Biological processi
- mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- stem cell differentiation Source: RGD
Keywordsi
Molecular function | DNA-binding, RNA-binding |
Biological process | mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: PHD finger-like domain-containing protein 5AShort name: PHD finger-like domain protein 5A Alternative name(s): Splicing factor 3B-associated 14 kDa protein Short name: SF3b14b |
Gene namesi | Name:Phf5a Synonyms:Ini |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621555, Phf5a |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus speckle By similarity
Nucleus
- nuclear matrix Source: RGD
- nuclear speck Source: UniProtKB
- nucleus Source: RGD
- precatalytic spliceosome Source: GO_Central
- U12-type spliceosomal complex Source: RGD
- U2 snRNP Source: UniProtKB
- U2-type precatalytic spliceosome Source: RGD
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000218718 | 2 – 110 | PHD finger-like domain-containing protein 5AAdd BLAST | 109 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 3 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P83871 |
PaxDbi | P83871 |
PRIDEi | P83871 |
PTM databases
iPTMneti | P83871 |
PhosphoSitePlusi | P83871 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSRNOG00000024170, Expressed in thymus and 22 other tissues |
ExpressionAtlasi | P83871, baseline and differential |
Genevisiblei | P83871, RN |
Interactioni
Subunit structurei
Interacts (via N-terminus) with U2AF1 and SRSF5; acts to bridge the two.
Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two (By similarity).
Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42. Within the SF3B complex interacts directly with SF3B1 and SF3B3. The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity).
Interacts with the PAF1 complex (PAF1C) composed of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Within the PAF1C interacts directly with CDC73 and WDR61.
Interacts with RNA polymerase II (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 17 | Interaction with SF3B3By similarity | 1 | |
Sitei | 100 | Interaction with RNABy similarity | 1 |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005837 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 51 | Interaction with SF3B1 AND SF3B3By similarityAdd BLAST | 17 | |
Regioni | 79 – 82 | Interaction with SF3B3By similarity | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1705, Eukaryota |
GeneTreei | ENSGT00390000018518 |
HOGENOMi | CLU_110369_2_0_1 |
InParanoidi | P83871 |
OMAi | CIICGAP |
OrthoDBi | 1477492at2759 |
PhylomeDBi | P83871 |
TreeFami | TF105627 |
Family and domain databases
InterProi | View protein in InterPro IPR005345, PHF5 |
PANTHERi | PTHR13120, PTHR13120, 1 hit |
Pfami | View protein in Pfam PF03660, PHF5, 1 hit |
PIRSFi | PIRSF016468, PHF5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAKHHPDLIF CRKQAGVAIG RLCEKCDGKC VICDSYVRPC TLVRICDECN
60 70 80 90 100
YGSYQGRCVI CGGPGVSDAY YCKECTIQEK DRDGCPKIVN LGSSKTDLFY
110
ERKKYGFKKR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7TPJ6 | Q7TPJ6_RAT | Ac2-246 | Phf5a | 102 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF495522 mRNA Translation: AAM14623.1 |
RefSeqi | NP_620243.1, NM_138888.1 |
Genome annotation databases
Ensembli | ENSRNOT00000005837; ENSRNOP00000005837; ENSRNOG00000024170 |
GeneIDi | 192246 |
KEGGi | rno:192246 |
UCSCi | RGD:621555, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF495522 mRNA Translation: AAM14623.1 |
RefSeqi | NP_620243.1, NM_138888.1 |
3D structure databases
SMRi | P83871 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005837 |
PTM databases
iPTMneti | P83871 |
PhosphoSitePlusi | P83871 |
Proteomic databases
jPOSTi | P83871 |
PaxDbi | P83871 |
PRIDEi | P83871 |
Genome annotation databases
Ensembli | ENSRNOT00000005837; ENSRNOP00000005837; ENSRNOG00000024170 |
GeneIDi | 192246 |
KEGGi | rno:192246 |
UCSCi | RGD:621555, rat |
Organism-specific databases
CTDi | 84844 |
RGDi | 621555, Phf5a |
Phylogenomic databases
eggNOGi | KOG1705, Eukaryota |
GeneTreei | ENSGT00390000018518 |
HOGENOMi | CLU_110369_2_0_1 |
InParanoidi | P83871 |
OMAi | CIICGAP |
OrthoDBi | 1477492at2759 |
PhylomeDBi | P83871 |
TreeFami | TF105627 |
Enzyme and pathway databases
Reactomei | R-RNO-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
PROi | PR:P83871 |
Gene expression databases
Bgeei | ENSRNOG00000024170, Expressed in thymus and 22 other tissues |
ExpressionAtlasi | P83871, baseline and differential |
Genevisiblei | P83871, RN |
Family and domain databases
InterProi | View protein in InterPro IPR005345, PHF5 |
PANTHERi | PTHR13120, PTHR13120, 1 hit |
Pfami | View protein in Pfam PF03660, PHF5, 1 hit |
PIRSFi | PIRSF016468, PHF5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHF5A_RAT | |
Accessioni | P83871Primary (citable) accession number: P83871 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families