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Protein

Orexigenic neuropeptide QRFP

Gene

QRFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Orexigenic neuropeptide QRFP
Alternative name(s):
P518
Cleaved into the following chain:
Alternative name(s):
Neuropeptide RF-amide
Pyroglutamylated arginine-phenylalanine-amide peptide
Gene namesi
Name:QRFPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000188710.2
HGNCiHGNC:29982 QRFP
MIMi609795 gene
neXtProtiNX_P83859

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi347148
OpenTargetsiENSG00000188710
PharmGKBiPA162400554

Polymorphism and mutation databases

BioMutaiQRFP
DMDMi50400831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001008619 – 90Sequence analysisCuratedAdd BLAST72
PeptideiPRO_000001008791 – 133QRF-amideCuratedAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Pyrrolidone carboxylic acidBy similarityCurated1
Modified residuei133Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP83859
PeptideAtlasiP83859
PRIDEiP83859
ProteomicsDBi57739

Expressioni

Tissue specificityi

Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000188710 Expressed in 70 organ(s), highest expression level in urinary bladder
CleanExiHS_QRFP

Organism-specific databases

HPAiHPA043377

Interactioni

Subunit structurei

Ligand for the G-protein coupled receptor QRFPR/GPR103.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345487

Structurei

3D structure databases

ProteinModelPortaliP83859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFamide neuropeptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZA2 Eukaryota
ENOG410YYZS LUCA
GeneTreeiENSGT00390000015756
HOGENOMiHOG000231990
HOVERGENiHBG053386
InParanoidiP83859
OMAiCRFRFGR
OrthoDBiEOG091G16YK
PhylomeDBiP83859
TreeFamiTF336317

Family and domain databases

InterProiView protein in InterPro
IPR024565 P518
PANTHERiPTHR36476 PTHR36476, 1 hit
PfamiView protein in Pfam
PF11109 RFamide_26RFa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD786889 PD786889, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83859-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRPYPLIYF LFLPLGACFP LLDRREPTDA MGGLGAGERW ADLAMGPRPH
60 70 80 90 100
SVWGSSRWLR ASQPQALLVI ARGLQTSGRE HAGCRFRFGR QDEGSEATGF
110 120 130
LPAAGEKTSG PLGNLAEELN GYSRKKGGFS FRFGRR
Length:136
Mass (Da):14,941
Last modified:May 10, 2004 - v1
Checksum:i4FC036F7ADF4551F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04918468L → H. Corresponds to variant dbSNP:rs12340616Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109625 mRNA Translation: BAC98934.1
AY438326 Genomic DNA Translation: AAR24354.1
AL161733 Genomic DNA No translation available.
BC101127 mRNA Translation: AAI01128.1
CCDSiCCDS6936.1
RefSeqiNP_937823.1, NM_198180.2
UniGeneiHs.660704

Genome annotation databases

EnsembliENST00000343079; ENSP00000345487; ENSG00000188710
ENST00000623824; ENSP00000485512; ENSG00000188710
GeneIDi347148
KEGGihsa:347148
UCSCiuc011mcb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109625 mRNA Translation: BAC98934.1
AY438326 Genomic DNA Translation: AAR24354.1
AL161733 Genomic DNA No translation available.
BC101127 mRNA Translation: AAI01128.1
CCDSiCCDS6936.1
RefSeqiNP_937823.1, NM_198180.2
UniGeneiHs.660704

3D structure databases

ProteinModelPortaliP83859
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345487

Polymorphism and mutation databases

BioMutaiQRFP
DMDMi50400831

Proteomic databases

PaxDbiP83859
PeptideAtlasiP83859
PRIDEiP83859
ProteomicsDBi57739

Protocols and materials databases

DNASUi347148
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343079; ENSP00000345487; ENSG00000188710
ENST00000623824; ENSP00000485512; ENSG00000188710
GeneIDi347148
KEGGihsa:347148
UCSCiuc011mcb.2 human

Organism-specific databases

CTDi347148
DisGeNETi347148
EuPathDBiHostDB:ENSG00000188710.2
GeneCardsiQRFP
HGNCiHGNC:29982 QRFP
HPAiHPA043377
MIMi609795 gene
neXtProtiNX_P83859
OpenTargetsiENSG00000188710
PharmGKBiPA162400554
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZA2 Eukaryota
ENOG410YYZS LUCA
GeneTreeiENSGT00390000015756
HOGENOMiHOG000231990
HOVERGENiHBG053386
InParanoidiP83859
OMAiCRFRFGR
OrthoDBiEOG091G16YK
PhylomeDBiP83859
TreeFamiTF336317

Enzyme and pathway databases

ReactomeiR-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiiQRFP
GenomeRNAii347148
PROiPR:P83859
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188710 Expressed in 70 organ(s), highest expression level in urinary bladder
CleanExiHS_QRFP

Family and domain databases

InterProiView protein in InterPro
IPR024565 P518
PANTHERiPTHR36476 PTHR36476, 1 hit
PfamiView protein in Pfam
PF11109 RFamide_26RFa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD786889 PD786889, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOX26_HUMAN
AccessioniPrimary (citable) accession number: P83859
Secondary accession number(s): A3KFJ6, Q495K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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