UniProtKB - P83749 (FTSY_THEAQ)
Protein
Signal recognition particle receptor FtsY
Gene
ftsY
Organism
Thermus aquaticus
Status
Functioni
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 109 – 116 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 191 – 195 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 255 – 258 | GTPUniRule annotation | 4 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
GO - Biological processi
- SRP-dependent cotranslational protein targeting to membrane Source: InterPro
Keywordsi
Molecular function | Receptor |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Signal recognition particle receptor FtsYUniRule annotationShort name: SRP receptorUniRule annotation |
Gene namesi | Name:ftsYUniRule annotation |
Organismi | Thermus aquaticusImported |
Taxonomic identifieri | 271 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus |
Subcellular locationi
- Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- intrinsic component of plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 17 | R → Q: No effect on proteolysis; when associated with M-18. 1 Publication | 1 | |
Mutagenesisi | 18 | L → M: No effect on proteolysis; when associated with Q-17. 1 Publication | 1 | |
Mutagenesisi | 86 | R → Q: No effect proteolysis; when associated with Q-87 and I-88. 1 Publication | 1 | |
Mutagenesisi | 87 | K → Q: No effect proteolysis; when associated with Q-86 and I-88. 1 Publication | 1 | |
Mutagenesisi | 88 | L → I: No effect proteolysis; when associated with Q-86 and Q-87. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000101147 | 2 – 304 | Signal recognition particle receptor FtsYAdd BLAST | 303 |
Post-translational modificationi
Sensitive to endogenous proteolytic cleavage between residues 18 and 19 and between residues 86 and 87.
Interactioni
Subunit structurei
Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.
UniRule annotationBinary interactionsi
P83749
With | #Exp. | IntAct |
---|---|---|
ffh [O07347] | 2 | EBI-1037899,EBI-1037906 |
Protein-protein interaction databases
IntActi | P83749, 1 interactor |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P83749 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P83749 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.20.120.140, 1 hit |
HAMAPi | MF_00920, FtsY, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR013822, Signal_recog_particl_SRP54_hlx IPR004390, SR_rcpt_FtsY IPR036225, SRP/SRP_N IPR000897, SRP54_GTPase_dom IPR042101, SRP54_N_sf |
PANTHERi | PTHR43134:SF7, PTHR43134:SF7, 1 hit |
Pfami | View protein in Pfam PF00448, SRP54, 1 hit PF02881, SRP54_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00962, SRP54, 1 hit SM00963, SRP54_N, 1 hit |
SUPFAMi | SSF47364, SSF47364, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00064, ftsY, 1 hit |
PROSITEi | View protein in PROSITE PS00300, SRP54, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P83749-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFFDRLKAG LAKTRERLLK AIPWGGNLEE VLEELEMALL AADVGLSATE
60 70 80 90 100
EILQEVRASG RKDLKEAVKE KLVGMLEPDE RRATLRKLGF NPQKPKPVEP
110 120 130 140 150
KGRVVLVVGV NGVGKTTTIA KLGRYYQNLG KKVMFCAGDT FRAAGGTQLS
160 170 180 190 200
EWGKRLSIPV IQGPEGTDPA ALAYDAVQAM KARGYDLLFV DTAGRLHTKH
210 220 230 240 250
NLMEELKKVK RAIAKADPEE PKEVWLVLDA VTGQNGLEQA KKFHEAVGLT
260 270 280 290 300
GVIVTKLDGT AKGGVLIPIV RTLKVPIKFV GVGEGPDDLQ PFDPEAFVEA
LLED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY484668 Genomic DNA Translation: AAR28967.1 |
RefSeqi | WP_053767748.1, NZ_LHCI01000106.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY484668 Genomic DNA Translation: AAR28967.1 |
RefSeqi | WP_053767748.1, NZ_LHCI01000106.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OKK | X-ray | 2.05 | D | 2-304 | [»] | |
1RJ9 | X-ray | 1.90 | A | 1-304 | [»] | |
2CNW | X-ray | 2.39 | D/E/F | 21-304 | [»] | |
2IYL | X-ray | 2.10 | D | 21-304 | [»] | |
2J7P | X-ray | 1.97 | D/E | 22-304 | [»] | |
2Q9A | X-ray | 2.24 | A/B | 1-304 | [»] | |
2Q9B | X-ray | 2.30 | A/B | 1-304 | [»] | |
2Q9C | X-ray | 2.20 | A/B | 1-304 | [»] | |
2XKV | electron microscopy | 13.50 | D | 2-304 | [»] | |
SMRi | P83749 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P83749, 1 interactor |
Miscellaneous databases
EvolutionaryTracei | P83749 |
Family and domain databases
Gene3Di | 1.20.120.140, 1 hit |
HAMAPi | MF_00920, FtsY, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR013822, Signal_recog_particl_SRP54_hlx IPR004390, SR_rcpt_FtsY IPR036225, SRP/SRP_N IPR000897, SRP54_GTPase_dom IPR042101, SRP54_N_sf |
PANTHERi | PTHR43134:SF7, PTHR43134:SF7, 1 hit |
Pfami | View protein in Pfam PF00448, SRP54, 1 hit PF02881, SRP54_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00962, SRP54, 1 hit SM00963, SRP54_N, 1 hit |
SUPFAMi | SSF47364, SSF47364, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00064, ftsY, 1 hit |
PROSITEi | View protein in PROSITE PS00300, SRP54, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSY_THEAQ | |
Accessioni | P83749Primary (citable) accession number: P83749 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | August 12, 2020 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families