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Protein

Kappa-theraphotoxin-Tb1c

Gene
N/A
Organism
Theraphosa blondi (Goliath birdeating spider)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks Kv4.2/KCND2 voltage-gated potassium channels probably by shifting the voltage-dependence of channel activation to more depolarized potentials and by binding to the S3-S4 linker region of the voltage sensor domain.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-theraphotoxin-Tb1c
Short name:
Kappa-TRTX-Tb1c
Alternative name(s):
Theraphotoxin-3
TlTx32 Publications
OrganismiTheraphosa blondi (Goliath birdeating spider)Curated
Taxonomic identifieri260533 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeTheraphosa

Organism-specific databases

ArachnoServeriAS000277 kappa-theraphotoxin-Tb1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000450281 – 35Kappa-theraphotoxin-Tb1cAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 18By similarity
Disulfide bondi10 ↔ 23By similarity
Disulfide bondi17 ↔ 30By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliP83747
SMRiP83747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR011696 Huwentoxin-1
PfamiView protein in Pfam
PF07740 Toxin_12, 1 hit

Sequencei

Sequence statusi: Complete.

P83747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
DDCLGMFSSC DPNNDKCCPN RVCRVRDQWC KYKLW
Length:35
Mass (Da):4,200
Last modified:February 2, 2004 - v1
Checksum:i2DDC9DD502A0BB16
GO

Mass spectrometryi

Molecular mass is 4208.78 Da from positions 1 - 35. Determined by ESI. 1 Publication
Molecular mass is 4205.88 Da from positions 1 - 35. Determined by MALDI. Monoisotopic mass.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP83747
SMRiP83747
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000277 kappa-theraphotoxin-Tb1c

Family and domain databases

InterProiView protein in InterPro
IPR011696 Huwentoxin-1
PfamiView protein in Pfam
PF07740 Toxin_12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTX3_THEBL
AccessioniPrimary (citable) accession number: P83747
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 2, 2004
Last modified: June 20, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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