UniProtKB - P83741 (WNK1_MOUSE)

BLAST

>sp|P83741|WNK1_MOUSE Serine/threonine-protein kinase WNK1 OS=Mus musculus OX=10090 GN=Wnk1 PE=1 SV=2
MSDGAAEKQSGTPGFLTPPAPVPKNGSSSDSSVGEKLGATVADSGVGRTEEYRRRRHTMD
KDSRGAAATTTPTEHRFFRRSVICDSNATALELPGLPLSIPQPSVPAVVPQSAPPEPHRE
ETLTATVASQVSQQPSAAASPGEQAVVGSATTTVPSSTSKDRPVSQPSLVGSKEEPPPSR
SGSGSGGASAKEAQEDRSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLD
TETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLV
TELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEY
PYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ
EETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEM
VESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKRKQEESSFKQQNEQQASVS
QAGIQQLSAASTGIPTAPATSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTIDSGQ
GSSVFTESRVSSQQTVSYGSQHEQAHSTGTAPGHTVSSIQAQSQPHGVYPPSSMAQGQNQ
GQPSSSLAGVLSSQPIQHPQQQGIQPTVPSQQAVQYSLPQAASSSEGTTAQPVSQPQVSA
GTQLPVSQTVATVQGEPHIPVSTQPSVVPVHSGAHFLPMGQPIPTSLLPQYPVSQIPIST
PHVSTAQTGFSSVPITMAAGINQPLLTLASSATASSIPGGSPVVPNQLPTLLQPVNQLQS
QVHPQLLQPTTVQSIGIPANLGQAAEGPLPSGDVLYQGFPSRLPPQYPGDSNIAPSSNVA
SVCIHSTVLAPPSMPTEALATQGYFPTVVQPYVESTPLVPMGSVGGQVQVSQPAVSLTQQ
PPTTSSQQAVLESTQGVSQAAPPEQTPITQSQPTQPVPLVTSADSAHSDVASGMSDGNEN
APSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMV
TFKFDLDGDNPEEIATIMVNNDFILAIERESFVAQVREIIEKADEMLSEDVSVEPEGDQG
LESLQGKDDYGFPGSQKLEGEFKQPIAVSSMPQQIGVPTSSLTQVVHSAGRRFIVSPVPE
SRLRESKVFTSDISDPVVASTSQAPGMNLSHSASSLSLQQAFSELKHGQMTEGPNTAPPN
FNHMAGPTFSPFLASIAGVQTVAASTPSVSVPITSSPLNDISTSVMQSETALPTEKGIVG
VTTTSTGVVASGGLTTMSVSESPTSSSAVSSSTVPAVVTVSTPSQPVQASTSGSIASSTG
SFPPGTFSTTTATTMGSVVAPDAKPPTVLLQQVASNTAGVAIVTSVSTTTPFPGMASQPS
LPLSSSTSAPTLAETMVVSAHSLDKASHSSTAGLGLSFCAPSSSSSSGTAVSTSVSQPGM
VHPLVISSAVVSTPGLPQPVVPTSTPLLPQVPNIPPLVQPVVNVPAVQQTLIHSQPQPAL
LPNQPHTHCPEMDADTQSKAPGIDDIKTLEEKLRSLFSEHSSSGTQHASVSLETPLVVET
TVTPGITTTAVAPSKLMTSTTSTCLPPTSLPLGAAGMPVMPVGTPGQVSTPGTHASAPVG
TATGVKPGTTPPKPTKTVVPPVGTELSAGTVPCEQLPPFPGPSLIQSQQPLEDLDAQLRR
TLSPETITVAPAVGPLSTMSSTTVTEAGTRLQKDGTEGHVTATSSGAGVVKMGRFQVSVT
MDDAQKERKNRSEDTKSVHFESSTSESSVLSSSSPESTLVKPEPNGISISGISLDVPDST
HKAPTPEAKSDAGQPTKVGRFQVTTTANKVGRFSVSRTEDKVTELKKEGPVTSPPFRDSE
QTVIPAVIPKKEKPELAEPSHLNGPSSDLEAAFLSRGTEDGSGSPHSPPHLCSKSLPVQN
LSQSLSNSFNSSYMSSDNESDIEDEDLRLELRRLREKHLKEIQDLQSRQKHEIESLYTKL
GKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSGTSVLHPQQ
TLHPAGNTPETGHNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGGT
VSSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKF
SAPGQLCVPMTSNLGGSTPISAASATSLGHFTKSMCPPQQYGFPPAPFGTQWSGTGGPAP
QPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT

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History
Entry version 154 (10 Oct 2018)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

Serine/threonine-protein kinase WNK1

Gene

Wnk1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (PubMed:21317537, PubMed:23542070).3 Publications

Isoform 7: Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.By similarity

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity

It is uncertain whether Met-1 or Met-214 is the initiator.Curated

HSN2 was originally thought to be an intronless gene lying within a WNK1 gene intron. It has been shown to be a nervous system-specific exon of WNK1 included in isoform 2 and isoform 3 (PubMed:18521183).1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

By hypertonicity. Activation requires autophosphorylation of Ser-382. Phosphorylation of Ser-378 also promotes increased activity (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	231	ATP; via amide nitrogenBy similarity	1
Binding siteⁱ	351	ATPBy similarity	1
Active siteⁱ	368	Proton acceptorBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	301 – 304	ATPBy similarity		4

GO - Molecular functionⁱ

ATP binding Source: MGI
chloride channel inhibitor activity Source: MGI
magnesium ion binding Source: MGI
phosphatase binding Source: UniProtKB
potassium channel inhibitor activity Source: MGI
protein kinase activator activity Source: MGI
protein kinase activity
Source: MGI
Inferred from direct assayⁱ
- 15350218
protein kinase binding Source: MGI
protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
protein serine/threonine kinase inhibitor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to calcium ion Source: MGI
cellular response to chemokine
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
chemokine (C-C motif) ligand 21 signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
intracellular signal transduction Source: MGI
ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 12671053
lymphocyte migration into lymph node
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
negative regulation of cell-cell adhesion mediated by integrin Source: Ensembl
negative regulation of GTPase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
negative regulation of heterotypic cell-cell adhesion Source: Ensembl
negative regulation of kinase activity Source: MGI
negative regulation of leukocyte cell-cell adhesion Source: Ensembl
negative regulation of pancreatic juice secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 21317537
negative regulation of phosphatase activity Source: UniProtKB
negative regulation of sodium ion transport Source: UniProtKB
peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149
positive regulation of canonical Wnt signaling pathway Source: MGI
positive regulation of systemic arterial blood pressure
Source: MGI
Inferred from mutant phenotypeⁱ
- 14610273
positive regulation of T cell chemotaxis Source: Ensembl
protein autophosphorylation Source: MGI
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 15350218
regulation of cellular process
Source: UniProtKB
Inferred from direct assayⁱ
- 12671053
regulation of sodium ion transport Source: UniProtKB
signal transduction by trans-phosphorylation Source: MGI
T cell receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27400149

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase WNK1Curated (EC:2.7.11.1By similarity) Alternative name(s): Protein kinase lysine-deficient 1Imported Protein kinase with no lysine 11 Publication
Gene namesⁱ	Name:Wnk1Imported Synonyms:Hsn21 Publication, Prkwnk1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2442092 Wnk1

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	368	D → A: No effect on inhibition of SLC4A4. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL2176799

ChEMBLⁱ

CHEMBL2176799

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086820	1 – 2377	Serine/threonine-protein kinase WNK1Add BLAST		2377

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	17	PhosphothreonineCombined sources	1
Modified residueⁱ	165	PhosphoserineBy similarity	1
Modified residueⁱ	172	PhosphoserineBy similarity	1
Modified residueⁱ	378	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	382	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	1256	PhosphoserineBy similarity	1
Modified residueⁱ	1973	PhosphoserineBy similarity	1
Modified residueⁱ	2006	PhosphoserineBy similarity	1
Modified residueⁱ	2007	PhosphoserineBy similarity	1
Modified residueⁱ	2022	PhosphoserineBy similarity	1
Modified residueⁱ	2024	PhosphoserineBy similarity	1
Modified residueⁱ	2027	PhosphoserineCombined sources	1
Modified residueⁱ	2116	PhosphoserineBy similarity	1
Modified residueⁱ	2265	PhosphoserineCombined sources	1
Modified residueⁱ	2281	PhosphoserineCombined sources	1
Modified residueⁱ	2365	PhosphoserineBy similarity	1
Modified residueⁱ	2367	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Autophosphorylation at Ser-382 is inhibited by intracellular calcium.By similarity

Ubiquitinated in vitro by the BCR(KLHL3) complex and in vivo by a BCR(KLHL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P83741
PaxDbⁱ	P83741
PeptideAtlas More...PeptideAtlasⁱ	P83741
PRIDEⁱ	P83741

PTM databases

iPTMnetⁱ	P83741
PhosphoSitePlusⁱ	P83741

Expressionⁱ

Tissue specificityⁱ

Widely expressed in both adult and embryonic tissue, with highest levels observed in the testis and lower levels in heart, lung, kidney, placenta, brain and skeletal muscle. Expressed in pancreatic duct (PubMed:21317537). Two isoforms are expressed in heart, a single shorter isoform in the kidney. Locates to the distal convoluted tubule, the medullary collecting duct and the cortical collecting duct of the kidney. HSN2-containing isoform 2 and isoform 3 are restricted to the nervous system, expressed preferentially in sensory neurons than in motor neurons and in general more abundant in axons than in cell bodies (at protein level). In the DRG, predominantly expressed in the satellite cells that envelop sensory neurons, but low expression also observed in the cell bodies of neurons (at protein level). In the sciatic nerve, expressed in the Schwann cells that surround axons and in a mosaic distribution of axons (at protein level). In the spinal cord, expressed in superficial layers (LI and LII), as well as in the fibers of the Lissauer tract (at protein level). Also detected in the axon fibers of dorsolateral funiculus and lateral funiculus (at protein level).4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000045962 Expressed in 329 organ(s), highest expression level in endothelial cell of lymphatic vessel
CleanExⁱ	MM_WNK1
ExpressionAtlasⁱ	P83741 baseline and differential
Genevisibleⁱ	P83741 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SYT2. Interacts with KLHL3, WNK3 and WNK4 (By similarity). Isoform 7: Interacts with isoform 1 (By similarity).By similarity

GO - Molecular functionⁱ

phosphatase binding Source: UniProtKB
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	231244, 1 interactor
STRINGⁱ	10090.ENSMUSP00000086017

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P83741
SMRⁱ	P83741
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	221 – 479	Protein kinasePROSITE-ProRule annotationAdd BLAST		259

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	488 – 555	Autoinhibitory domainBy similarityAdd BLAST		68

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0584 Eukaryota ENOG410XQWZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124049
HOVERGENⁱ	HBG079897
InParanoidⁱ	P83741
KEGG Orthology (KO) More...KOⁱ	K08867
OMAⁱ	TQVVHSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06LL
PhylomeDBⁱ	P83741
TreeFamⁱ	TF315363

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR024678 Kinase_OSR1/WNK_CCT IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12202 OSR1_C, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P83741-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS 
       760        770        780        790        800
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQLPVSQTV ATVQGEPHIP 
       810        820        830        840        850
VSTQPSVVPV HSGAHFLPMG QPIPTSLLPQ YPVSQIPIST PHVSTAQTGF 
       860        870        880        890        900
SSVPITMAAG INQPLLTLAS SATASSIPGG SPVVPNQLPT LLQPVNQLQS 
       910        920        930        940        950
QVHPQLLQPT TVQSIGIPAN LGQAAEGPLP SGDVLYQGFP SRLPPQYPGD 
       960        970        980        990       1000
SNIAPSSNVA SVCIHSTVLA PPSMPTEALA TQGYFPTVVQ PYVESTPLVP 
      1010       1020       1030       1040       1050
MGSVGGQVQV SQPAVSLTQQ PPTTSSQQAV LESTQGVSQA APPEQTPITQ 
      1060       1070       1080       1090       1100
SQPTQPVPLV TSADSAHSDV ASGMSDGNEN APSSSGRHEG RTTKRHYRKS 
      1110       1120       1130       1140       1150
VRSRSRHEKT SRPKLRILNV SNKGDRVVEC QLETHNRKMV TFKFDLDGDN 
      1160       1170       1180       1190       1200
PEEIATIMVN NDFILAIERE SFVAQVREII EKADEMLSED VSVEPEGDQG 
      1210       1220       1230       1240       1250
LESLQGKDDY GFPGSQKLEG EFKQPIAVSS MPQQIGVPTS SLTQVVHSAG 
      1260       1270       1280       1290       1300
RRFIVSPVPE SRLRESKVFT SDISDPVVAS TSQAPGMNLS HSASSLSLQQ 
      1310       1320       1330       1340       1350
AFSELKHGQM TEGPNTAPPN FNHMAGPTFS PFLASIAGVQ TVAASTPSVS 
      1360       1370       1380       1390       1400
VPITSSPLND ISTSVMQSET ALPTEKGIVG VTTTSTGVVA SGGLTTMSVS 
      1410       1420       1430       1440       1450
ESPTSSSAVS SSTVPAVVTV STPSQPVQAS TSGSIASSTG SFPPGTFSTT 
      1460       1470       1480       1490       1500
TATTMGSVVA PDAKPPTVLL QQVASNTAGV AIVTSVSTTT PFPGMASQPS 
      1510       1520       1530       1540       1550
LPLSSSTSAP TLAETMVVSA HSLDKASHSS TAGLGLSFCA PSSSSSSGTA 
      1560       1570       1580       1590       1600
VSTSVSQPGM VHPLVISSAV VSTPGLPQPV VPTSTPLLPQ VPNIPPLVQP 
      1610       1620       1630       1640       1650
VVNVPAVQQT LIHSQPQPAL LPNQPHTHCP EMDADTQSKA PGIDDIKTLE 
      1660       1670       1680       1690       1700
EKLRSLFSEH SSSGTQHASV SLETPLVVET TVTPGITTTA VAPSKLMTST 
      1710       1720       1730       1740       1750
TSTCLPPTSL PLGAAGMPVM PVGTPGQVST PGTHASAPVG TATGVKPGTT 
      1760       1770       1780       1790       1800
PPKPTKTVVP PVGTELSAGT VPCEQLPPFP GPSLIQSQQP LEDLDAQLRR 
      1810       1820       1830       1840       1850
TLSPETITVA PAVGPLSTMS STTVTEAGTR LQKDGTEGHV TATSSGAGVV 
      1860       1870       1880       1890       1900
KMGRFQVSVT MDDAQKERKN RSEDTKSVHF ESSTSESSVL SSSSPESTLV 
      1910       1920       1930       1940       1950
KPEPNGISIS GISLDVPDST HKAPTPEAKS DAGQPTKVGR FQVTTTANKV 
      1960       1970       1980       1990       2000
GRFSVSRTED KVTELKKEGP VTSPPFRDSE QTVIPAVIPK KEKPELAEPS 
      2010       2020       2030       2040       2050
HLNGPSSDLE AAFLSRGTED GSGSPHSPPH LCSKSLPVQN LSQSLSNSFN 
      2060       2070       2080       2090       2100
SSYMSSDNES DIEDEDLRLE LRRLREKHLK EIQDLQSRQK HEIESLYTKL 
      2110       2120       2130       2140       2150
GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS PQLSGNLSGQ 
      2160       2170       2180       2190       2200
SGTSVLHPQQ TLHPAGNTPE TGHNQLLQPL KPSPSSDNLY SAFTSDGAIS 
      2210       2220       2230       2240       2250
VPSLSAPGQG TSSTNTVGGT VSSQAAQAQP PAMTSSRKGT FTDDLHKLVD 
      2260       2270       2280       2290       2300
NWARDAMNLS GRRGSKGHMN YEGPGMARKF SAPGQLCVPM TSNLGGSTPI 
      2310       2320       2330       2340       2350
SAASATSLGH FTKSMCPPQQ YGFPPAPFGT QWSGTGGPAP QPLGQFQPVG 
      2360       2370 
TASLQNFNIS NLQKSISNPP GSNLRTT

Length:2,377

Mass (Da):250,934

Last modified:November 30, 2010 - v2

Checksum:ⁱ0C4D288CCE50B8C6

Isoform 2 (identifier: P83741-2) [UniParc]FASTA Add to basket

Also known as: Brain and spinal cord variant

The sequence of this isoform differs from the canonical sequence as follows:
715-1032: AQGQNQGQPS...TTSSQQAVLE → PRRGRSMSVC...SQPQVSAGTQ

« Hide

        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMPRRGRS MSVCVPHLSA VPSLSRISPS APSTPPPVLS 
       760        770        780        790        800
APLCPSLLRT APEETFAEKL SKALESVLPM HSASQRKHRR SSLPSLFVTT 
       810        820        830        840        850
PQSMAHPCGG TPTYPESQIF FPTIHERPVS FSPPPTCPPK VAISQRRKST 
       860        870        880        890        900
SFLEAQTRHF QPLLRTVGQN HLPPGSSPTN WTPEAIVMLG ATANRVNREL 
       910        920        930        940        950
CEMQVQPVFE PTQIYSDYRP GLVLAEEAHY FIPQETVYLA GVHYQAQVAG 
       960        970        980        990       1000
QYEGISYNSP VLSSPMKQIS EQKPVPGGPA SSSVFEFPSG QAFLVGHLQN 
      1010       1020       1030       1040       1050
LRLDSGPSPA SPLSSISAPN STDATHLKFH PVFVPHSAPA VLTNSNENRS 
      1060       1070       1080       1090       1100
NCVFEFHAQT PSSSGEGGGI LPQRVYRNRQ VAVDSNQEEL SPQSVGLHCH 
      1110       1120       1130       1140       1150
LQPVTEEQRN NHAPELTISV VEPMGQIWPI GSPEYSSDSS QITSSDLSDF 
      1160       1170       1180       1190       1200
QSPPPTGGTA APFGSDVSLP FIRLPQTVLQ ESPLFFCFPQ GTTSQQVLSA 
      1210       1220       1230       1240       1250
SYSSGGSTLH PQAQGQNQGQ PSSSLAGVLS SQPIQHPQQQ GIQPTVPSQQ 
      1260       1270       1280       1290       1300
AVQYSLPQAA SSSEGTTAQP VSQPQVSAGT QSTQGVSQAA PPEQTPITQS 
      1310       1320       1330       1340       1350
QPTQPVPLVT SADSAHSDVA SGMSDGNENA PSSSGRHEGR TTKRHYRKSV 
      1360       1370       1380       1390       1400
RSRSRHEKTS RPKLRILNVS NKGDRVVECQ LETHNRKMVT FKFDLDGDNP 
      1410       1420       1430       1440       1450
EEIATIMVNN DFILAIERES FVAQVREIIE KADEMLSEDV SVEPEGDQGL 
      1460       1470       1480       1490       1500
ESLQGKDDYG FPGSQKLEGE FKQPIAVSSM PQQIGVPTSS LTQVVHSAGR 
      1510       1520       1530       1540       1550
RFIVSPVPES RLRESKVFTS DISDPVVAST SQAPGMNLSH SASSLSLQQA 
      1560       1570       1580       1590       1600
FSELKHGQMT EGPNTAPPNF NHMAGPTFSP FLASIAGVQT VAASTPSVSV 
      1610       1620       1630       1640       1650
PITSSPLNDI STSVMQSETA LPTEKGIVGV TTTSTGVVAS GGLTTMSVSE 
      1660       1670       1680       1690       1700
SPTSSSAVSS STVPAVVTVS TPSQPVQAST SGSIASSTGS FPPGTFSTTT 
      1710       1720       1730       1740       1750
ATTMGSVVAP DAKPPTVLLQ QVASNTAGVA IVTSVSTTTP FPGMASQPSL 
      1760       1770       1780       1790       1800
PLSSSTSAPT LAETMVVSAH SLDKASHSST AGLGLSFCAP SSSSSSGTAV 
      1810       1820       1830       1840       1850
STSVSQPGMV HPLVISSAVV STPGLPQPVV PTSTPLLPQV PNIPPLVQPV 
      1860       1870       1880       1890       1900
VNVPAVQQTL IHSQPQPALL PNQPHTHCPE MDADTQSKAP GIDDIKTLEE 
      1910       1920       1930       1940       1950
KLRSLFSEHS SSGTQHASVS LETPLVVETT VTPGITTTAV APSKLMTSTT 
      1960       1970       1980       1990       2000
STCLPPTSLP LGAAGMPVMP VGTPGQVSTP GTHASAPVGT ATGVKPGTTP 
      2010       2020       2030       2040       2050
PKPTKTVVPP VGTELSAGTV PCEQLPPFPG PSLIQSQQPL EDLDAQLRRT 
      2060       2070       2080       2090       2100
LSPETITVAP AVGPLSTMSS TTVTEAGTRL QKDGTEGHVT ATSSGAGVVK 
      2110       2120       2130       2140       2150
MGRFQVSVTM DDAQKERKNR SEDTKSVHFE SSTSESSVLS SSSPESTLVK 
      2160       2170       2180       2190       2200
PEPNGISISG ISLDVPDSTH KAPTPEAKSD AGQPTKVGRF QVTTTANKVG 
      2210       2220       2230       2240       2250
RFSVSRTEDK VTELKKEGPV TSPPFRDSEQ TVIPAVIPKK EKPELAEPSH 
      2260       2270       2280       2290       2300
LNGPSSDLEA AFLSRGTEDG SGSPHSPPHL CSKSLPVQNL SQSLSNSFNS 
      2310       2320       2330       2340       2350
SYMSSDNESD IEDEDLRLEL RRLREKHLKE IQDLQSRQKH EIESLYTKLG 
      2360       2370       2380       2390       2400
KVPPAVIIPP AAPLSGRRRR PTKSKGSKSS RSSSLGNKSP QLSGNLSGQS 
      2410       2420       2430       2440       2450
GTSVLHPQQT LHPAGNTPET GHNQLLQPLK PSPSSDNLYS AFTSDGAISV 
      2460       2470       2480       2490       2500
PSLSAPGQGT SSTNTVGGTV SSQAAQAQPP AMTSSRKGTF TDDLHKLVDN 
      2510       2520       2530       2540       2550
WARDAMNLSG RRGSKGHMNY EGPGMARKFS APGQLCVPMT SNLGGSTPIS 
      2560       2570       2580       2590       2600
AASATSLGHF TKSMCPPQQY GFPPAPFGTQ WSGTGGPAPQ PLGQFQPVGT 
      2610       2620 
ASLQNFNISN LQKSISNPPG SNLRTT

Note: This isoform which includes the HSN2 exon has been identified in human and mouse. The sequence shown here is the result of gene prediction.

Show »

Length:2,626

Mass (Da):279,185

Checksum:ⁱ1933C3D136EE2103

Isoform 3 (identifier: P83741-3) [UniParc]FASTA Add to basket

Also known as: Dorsal root ganglia and sciatic nerve variant, DRG and sciatic nerve variant

The sequence of this isoform differs from the canonical sequence as follows:
715-936: AQGQNQGQPS...GPLPSGDVLY → PQSMAHPCGG...VSQPQVSAGT

« Hide

        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMPQSMAH PCGGTPTYPE SQIFFPTIHE RPVSFSPPPT 
       760        770        780        790        800
CPPKVAISQR RKSTSFLEAQ TRHFQPLLRT VGQNHLPPGS SPTNWTPEAI 
       810        820        830        840        850
VMLGATANRV NRELCEMQVQ PVFEPTQIYS DYRPGLVLAE EAHYFIPQET 
       860        870        880        890        900
VYLAGVHYQA QVAGQYEGIS YNSPVLSSPM KQISEQKPVP GGPASSSVFE 
       910        920        930        940        950
FPSGQAFLVG HLQNLRLDSG PSPASPLSSI SAPNSTDATH LKFHPVFVPH 
       960        970        980        990       1000
SAPAVLTNSN ENRSNCVFEF HAQTPSSSGE GGGILPQRVY RNRQVAVDSN 
      1010       1020       1030       1040       1050
QEELSPQSVG LHCHLQPVTE EQRNNHAPEL TISVVEPMGQ IWPIGSPEYS 
      1060       1070       1080       1090       1100
SDSSQITSSD LSDFQSPPPT GGTAAPFGSD VSLPFIRLPQ TVLQESPLFF 
      1110       1120       1130       1140       1150
CFPQGTTSQQ VLSASYSSGG STLHPQAQGQ NQGQPSSSLA GVLSSQPIQH 
      1160       1170       1180       1190       1200
PQQQGIQPTV PSQQAVQYSL PQAASSSEGT TAQPVSQPQV SAGTQGFPSR 
      1210       1220       1230       1240       1250
LPPQYPGDSN IAPSSNVASV CIHSTVLAPP SMPTEALATQ GYFPTVVQPY 
      1260       1270       1280       1290       1300
VESTPLVPMG SVGGQVQVSQ PAVSLTQQPP TTSSQQAVLE STQGVSQAAP 
      1310       1320       1330       1340       1350
PEQTPITQSQ PTQPVPLVTS ADSAHSDVAS GMSDGNENAP SSSGRHEGRT 
      1360       1370       1380       1390       1400
TKRHYRKSVR SRSRHEKTSR PKLRILNVSN KGDRVVECQL ETHNRKMVTF 
      1410       1420       1430       1440       1450
KFDLDGDNPE EIATIMVNND FILAIERESF VAQVREIIEK ADEMLSEDVS 
      1460       1470       1480       1490       1500
VEPEGDQGLE SLQGKDDYGF PGSQKLEGEF KQPIAVSSMP QQIGVPTSSL 
      1510       1520       1530       1540       1550
TQVVHSAGRR FIVSPVPESR LRESKVFTSD ISDPVVASTS QAPGMNLSHS 
      1560       1570       1580       1590       1600
ASSLSLQQAF SELKHGQMTE GPNTAPPNFN HMAGPTFSPF LASIAGVQTV 
      1610       1620       1630       1640       1650
AASTPSVSVP ITSSPLNDIS TSVMQSETAL PTEKGIVGVT TTSTGVVASG 
      1660       1670       1680       1690       1700
GLTTMSVSES PTSSSAVSSS TVPAVVTVST PSQPVQASTS GSIASSTGSF 
      1710       1720       1730       1740       1750
PPGTFSTTTA TTMGSVVAPD AKPPTVLLQQ VASNTAGVAI VTSVSTTTPF 
      1760       1770       1780       1790       1800
PGMASQPSLP LSSSTSAPTL AETMVVSAHS LDKASHSSTA GLGLSFCAPS 
      1810       1820       1830       1840       1850
SSSSSGTAVS TSVSQPGMVH PLVISSAVVS TPGLPQPVVP TSTPLLPQVP 
      1860       1870       1880       1890       1900
NIPPLVQPVV NVPAVQQTLI HSQPQPALLP NQPHTHCPEM DADTQSKAPG 
      1910       1920       1930       1940       1950
IDDIKTLEEK LRSLFSEHSS SGTQHASVSL ETPLVVETTV TPGITTTAVA 
      1960       1970       1980       1990       2000
PSKLMTSTTS TCLPPTSLPL GAAGMPVMPV GTPGQVSTPG THASAPVGTA 
      2010       2020       2030       2040       2050
TGVKPGTTPP KPTKTVVPPV GTELSAGTVP CEQLPPFPGP SLIQSQQPLE 
      2060       2070       2080       2090       2100
DLDAQLRRTL SPETITVAPA VGPLSTMSST TVTEAGTRLQ KDGTEGHVTA 
      2110       2120       2130       2140       2150
TSSGAGVVKM GRFQVSVTMD DAQKERKNRS EDTKSVHFES STSESSVLSS 
      2160       2170       2180       2190       2200
SSPESTLVKP EPNGISISGI SLDVPDSTHK APTPEAKSDA GQPTKVGRFQ 
      2210       2220       2230       2240       2250
VTTTANKVGR FSVSRTEDKV TELKKEGPVT SPPFRDSEQT VIPAVIPKKE 
      2260       2270       2280       2290       2300
KPELAEPSHL NGPSSDLEAA FLSRGTEDGS GSPHSPPHLC SKSLPVQNLS 
      2310       2320       2330       2340       2350
QSLSNSFNSS YMSSDNESDI EDEDLRLELR RLREKHLKEI QDLQSRQKHE 
      2360       2370       2380       2390       2400
IESLYTKLGK VPPAVIIPPA APLSGRRRRP TKSKGSKSSR SSSLGNKSPQ 
      2410       2420       2430       2440       2450
LSGNLSGQSG TSVLHPQQTL HPAGNTPETG HNQLLQPLKP SPSSDNLYSA 
      2460       2470       2480       2490       2500
FTSDGAISVP SLSAPGQGTS STNTVGGTVS SQAAQAQPPA MTSSRKGTFT 
      2510       2520       2530       2540       2550
DDLHKLVDNW ARDAMNLSGR RGSKGHMNYE GPGMARKFSA PGQLCVPMTS 
      2560       2570       2580       2590       2600
NLGGSTPISA ASATSLGHFT KSMCPPQQYG FPPAPFGTQW SGTGGPAPQP 
      2610       2620       2630 
LGQFQPVGTA SLQNFNISNL QKSISNPPGS NLRTT

Note: This isoform which includes the HSN2 exon has been identified in human and mouse. The sequence shown here is the result of gene prediction.

Show »

Length:2,635

Mass (Da):279,763

Checksum:ⁱ8E2B08C9DCB624BF

Isoform 4 (identifier: P83741-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
784-1032: Missing.

« Hide

        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS 
       760        770        780        790        800
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQSTQGVSQ AAPPEQTPIT 
       810        820        830        840        850
QSQPTQPVPL VTSADSAHSD VASGMSDGNE NAPSSSGRHE GRTTKRHYRK 
       860        870        880        890        900
SVRSRSRHEK TSRPKLRILN VSNKGDRVVE CQLETHNRKM VTFKFDLDGD 
       910        920        930        940        950
NPEEIATIMV NNDFILAIER ESFVAQVREI IEKADEMLSE DVSVEPEGDQ 
       960        970        980        990       1000
GLESLQGKDD YGFPGSQKLE GEFKQPIAVS SMPQQIGVPT SSLTQVVHSA 
      1010       1020       1030       1040       1050
GRRFIVSPVP ESRLRESKVF TSDISDPVVA STSQAPGMNL SHSASSLSLQ 
      1060       1070       1080       1090       1100
QAFSELKHGQ MTEGPNTAPP NFNHMAGPTF SPFLASIAGV QTVAASTPSV 
      1110       1120       1130       1140       1150
SVPITSSPLN DISTSVMQSE TALPTEKGIV GVTTTSTGVV ASGGLTTMSV 
      1160       1170       1180       1190       1200
SESPTSSSAV SSSTVPAVVT VSTPSQPVQA STSGSIASST GSFPPGTFST 
      1210       1220       1230       1240       1250
TTATTMGSVV APDAKPPTVL LQQVASNTAG VAIVTSVSTT TPFPGMASQP 
      1260       1270       1280       1290       1300
SLPLSSSTSA PTLAETMVVS AHSLDKASHS STAGLGLSFC APSSSSSSGT 
      1310       1320       1330       1340       1350
AVSTSVSQPG MVHPLVISSA VVSTPGLPQP VVPTSTPLLP QVPNIPPLVQ 
      1360       1370       1380       1390       1400
PVVNVPAVQQ TLIHSQPQPA LLPNQPHTHC PEMDADTQSK APGIDDIKTL 
      1410       1420       1430       1440       1450
EEKLRSLFSE HSSSGTQHAS VSLETPLVVE TTVTPGITTT AVAPSKLMTS 
      1460       1470       1480       1490       1500
TTSTCLPPTS LPLGAAGMPV MPVGTPGQVS TPGTHASAPV GTATGVKPGT 
      1510       1520       1530       1540       1550
TPPKPTKTVV PPVGTELSAG TVPCEQLPPF PGPSLIQSQQ PLEDLDAQLR 
      1560       1570       1580       1590       1600
RTLSPETITV APAVGPLSTM SSTTVTEAGT RLQKDGTEGH VTATSSGAGV 
      1610       1620       1630       1640       1650
VKMGRFQVSV TMDDAQKERK NRSEDTKSVH FESSTSESSV LSSSSPESTL 
      1660       1670       1680       1690       1700
VKPEPNGISI SGISLDVPDS THKAPTPEAK SDAGQPTKVG RFQVTTTANK 
      1710       1720       1730       1740       1750
VGRFSVSRTE DKVTELKKEG PVTSPPFRDS EQTVIPAVIP KKEKPELAEP 
      1760       1770       1780       1790       1800
SHLNGPSSDL EAAFLSRGTE DGSGSPHSPP HLCSKSLPVQ NLSQSLSNSF 
      1810       1820       1830       1840       1850
NSSYMSSDNE SDIEDEDLRL ELRRLREKHL KEIQDLQSRQ KHEIESLYTK 
      1860       1870       1880       1890       1900
LGKVPPAVII PPAAPLSGRR RRPTKSKGSK SSRSSSLGNK SPQLSGNLSG 
      1910       1920       1930       1940       1950
QSGTSVLHPQ QTLHPAGNTP ETGHNQLLQP LKPSPSSDNL YSAFTSDGAI 
      1960       1970       1980       1990       2000
SVPSLSAPGQ GTSSTNTVGG TVSSQAAQAQ PPAMTSSRKG TFTDDLHKLV 
      2010       2020       2030       2040       2050
DNWARDAMNL SGRRGSKGHM NYEGPGMARK FSAPGQLCVP MTSNLGGSTP 
      2060       2070       2080       2090       2100
ISAASATSLG HFTKSMCPPQ QYGFPPAPFG TQWSGTGGPA PQPLGQFQPV 
      2110       2120 
GTASLQNFNI SNLQKSISNP PGSNLRTT

Note: No experimental confirmation available.

Show »

Length:2,128

Mass (Da):225,405

Checksum:ⁱA414E93D815771CE

Isoform 5 (identifier: P83741-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
784-937: Missing.
1787-1814: Missing.

« Hide

        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS 
       760        770        780        790        800
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQGFPSRLP PQYPGDSNIA 
       810        820        830        840        850
PSSNVASVCI HSTVLAPPSM PTEALATQGY FPTVVQPYVE STPLVPMGSV 
       860        870        880        890        900
GGQVQVSQPA VSLTQQPPTT SSQQAVLEST QGVSQAAPPE QTPITQSQPT 
       910        920        930        940        950
QPVPLVTSAD SAHSDVASGM SDGNENAPSS SGRHEGRTTK RHYRKSVRSR 
       960        970        980        990       1000
SRHEKTSRPK LRILNVSNKG DRVVECQLET HNRKMVTFKF DLDGDNPEEI 
      1010       1020       1030       1040       1050
ATIMVNNDFI LAIERESFVA QVREIIEKAD EMLSEDVSVE PEGDQGLESL 
      1060       1070       1080       1090       1100
QGKDDYGFPG SQKLEGEFKQ PIAVSSMPQQ IGVPTSSLTQ VVHSAGRRFI 
      1110       1120       1130       1140       1150
VSPVPESRLR ESKVFTSDIS DPVVASTSQA PGMNLSHSAS SLSLQQAFSE 
      1160       1170       1180       1190       1200
LKHGQMTEGP NTAPPNFNHM AGPTFSPFLA SIAGVQTVAA STPSVSVPIT 
      1210       1220       1230       1240       1250
SSPLNDISTS VMQSETALPT EKGIVGVTTT STGVVASGGL TTMSVSESPT 
      1260       1270       1280       1290       1300
SSSAVSSSTV PAVVTVSTPS QPVQASTSGS IASSTGSFPP GTFSTTTATT 
      1310       1320       1330       1340       1350
MGSVVAPDAK PPTVLLQQVA SNTAGVAIVT SVSTTTPFPG MASQPSLPLS 
      1360       1370       1380       1390       1400
SSTSAPTLAE TMVVSAHSLD KASHSSTAGL GLSFCAPSSS SSSGTAVSTS 
      1410       1420       1430       1440       1450
VSQPGMVHPL VISSAVVSTP GLPQPVVPTS TPLLPQVPNI PPLVQPVVNV 
      1460       1470       1480       1490       1500
PAVQQTLIHS QPQPALLPNQ PHTHCPEMDA DTQSKAPGID DIKTLEEKLR 
      1510       1520       1530       1540       1550
SLFSEHSSSG TQHASVSLET PLVVETTVTP GITTTAVAPS KLMTSTTSTC 
      1560       1570       1580       1590       1600
LPPTSLPLGA AGMPVMPVGT PGQVSTPGTH ASAPVGTATG VKPGTTPPKP 
      1610       1620       1630       1640       1650
TKTVVPPVGT ELSAGTVPCE QLPPFPGPSL IQPLSTMSST TVTEAGTRLQ 
      1660       1670       1680       1690       1700
KDGTEGHVTA TSSGAGVVKM GRFQVSVTMD DAQKERKNRS EDTKSVHFES 
      1710       1720       1730       1740       1750
STSESSVLSS SSPESTLVKP EPNGISISGI SLDVPDSTHK APTPEAKSDA 
      1760       1770       1780       1790       1800
GQPTKVGRFQ VTTTANKVGR FSVSRTEDKV TELKKEGPVT SPPFRDSEQT 
      1810       1820       1830       1840       1850
VIPAVIPKKE KPELAEPSHL NGPSSDLEAA FLSRGTEDGS GSPHSPPHLC 
      1860       1870       1880       1890       1900
SKSLPVQNLS QSLSNSFNSS YMSSDNESDI EDEDLRLELR RLREKHLKEI 
      1910       1920       1930       1940       1950
QDLQSRQKHE IESLYTKLGK VPPAVIIPPA APLSGRRRRP TKSKGSKSSR 
      1960       1970       1980       1990       2000
SSSLGNKSPQ LSGNLSGQSG TSVLHPQQTL HPAGNTPETG HNQLLQPLKP 
      2010       2020       2030       2040       2050
SPSSDNLYSA FTSDGAISVP SLSAPGQGTS STNTVGGTVS SQAAQAQPPA 
      2060       2070       2080       2090       2100
MTSSRKGTFT DDLHKLVDNW ARDAMNLSGR RGSKGHMNYE GPGMARKFSA 
      2110       2120       2130       2140       2150
PGQLCVPMTS NLGGSTPISA ASATSLGHFT KSMCPPQQYG FPPAPFGTQW 
      2160       2170       2180       2190 
SGTGGPAPQP LGQFQPVGTA SLQNFNISNL QKSISNPPGS NLRTT

Note: No experimental confirmation available.

Show »

Length:2,195

Mass (Da):232,203

Checksum:ⁱ43A9B0F75D83925D

Isoform 6 (identifier: P83741-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
784-788: LPVSQ → VNSNF
789-2377: Missing.

« Hide

        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS 
       760        770        780 
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQVNSNF

Note: May be due to intron retention. No experimental confirmation available.

Show »

Length:788

Mass (Da):86,037

Checksum:ⁱ75A4C9BD9B35580E

Isoform 7 (identifier: P83741-7) [UniParc]FASTA Add to basket

Also known as: KS-WNK1, Kidney-Specific1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1-437: MSDGAAEKQS...AAQIYRRVTS → MDFMKKDFCSVFVIVNSHCCCCSQKDCINE
543-2377: Missing.

« Hide

        10         20         30         40         50
MDFMKKDFCS VFVIVNSHCC CCSQKDCINE GVKPASFDKV AIPEVKEIIE 
        60         70         80         90        100
GCIRQNKDER YSIKDLLNHA FFQEETGVRV ELAEEDDGEK IAIKLWLRIE 
       110        120        130 
DIKKLKGKYK DNEAIEFSFD LERDVPEDVA QEMVE

Note: Kinase-defective isoform. Produced by alternative promoter usage and alternative splicing.1 Publication

Show »

Length:135

Mass (Da):15,643

Checksum:ⁱ652F45351044FFE8

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	F7CC62	F7CC62_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	405	Annotation score:
	A0A0R4J274	A0A0R4J274_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	433	Annotation score:
	F6U2S8	F6U2S8_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	281	Annotation score:
	F6S7V4	F6S7V4_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	85	Annotation score:
	F6TAR7	F6TAR7_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	200	Annotation score:
	F7CZC4	F7CZC4_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	407	Annotation score:
	J3QPK0	J3QPK0_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	238	Annotation score:
	F7B663	F7B663_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	67	Annotation score:
	F7CBK9	F7CBK9_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	213	Annotation score:
	F6V9V5	F6V9V5_MOUSE	Serine/threonine-protein kinase WNK... Serine/threonine-protein kinase WNK1	Wnk1	61	Annotation score:
There is more potential isoformShow all

Sequence cautionⁱ

The sequence AAI46010 differs from that shown. Probable cloning artifact.Curated

The sequence AAI46012 differs from that shown. Probable cloning artifact.Curated

The sequence BAD32213 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence DAA04493 differs from that shown. Reason: Erroneous gene model prediction. Includes 3' and 3' intronic sequences.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1220	G → R in AAQ77243 (PubMed:14514722).Curated		1
Sequence conflictⁱ	1230	S → C in AAQ77243 (PubMed:14514722).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_058592	1 – 437	MSDGA…RRVTS → MDFMKKDFCSVFVIVNSHCC CCSQKDCINE in isoform 7. Add BLAST	437
Alternative sequenceⁱVSP_058593	543 – 2377	Missing in isoform 7. Add BLAST	1835
Alternative sequenceⁱVSP_040271	715 – 1032	AQGQN…QAVLE → PRRGRSMSVCVPHLSAVPSL SRISPSAPSTPPPVLSAPLC PSLLRTAPEETFAEKLSKAL ESVLPMHSASQRKHRRSSLP SLFVTTPQSMAHPCGGTPTY PESQIFFPTIHERPVSFSPP PTCPPKVAISQRRKSTSFLE AQTRHFQPLLRTVGQNHLPP GSSPTNWTPEAIVMLGATAN RVNRELCEMQVQPVFEPTQI YSDYRPGLVLAEEAHYFIPQ ETVYLAGVHYQAQVAGQYEG ISYNSPVLSSPMKQISEQKP VPGGPASSSVFEFPSGQAFL VGHLQNLRLDSGPSPASPLS SISAPNSTDATHLKFHPVFV PHSAPAVLTNSNENRSNCVF EFHAQTPSSSGEGGGILPQR VYRNRQVAVDSNQEELSPQS VGLHCHLQPVTEEQRNNHAP ELTISVVEPMGQIWPIGSPE YSSDSSQITSSDLSDFQSPP PTGGTAAPFGSDVSLPFIRL PQTVLQESPLFFCFPQGTTS QQVLSASYSSGGSTLHPQAQ GQNQGQPSSSLAGVLSSQPI QHPQQQGIQPTVPSQQAVQY SLPQAASSSEGTTAQPVSQP QVSAGTQ in isoform 2. CuratedAdd BLAST	318
Alternative sequenceⁱVSP_040272	715 – 936	AQGQN…GDVLY → PQSMAHPCGGTPTYPESQIF FPTIHERPVSFSPPPTCPPK VAISQRRKSTSFLEAQTRHF QPLLRTVGQNHLPPGSSPTN WTPEAIVMLGATANRVNREL CEMQVQPVFEPTQIYSDYRP GLVLAEEAHYFIPQETVYLA GVHYQAQVAGQYEGISYNSP VLSSPMKQISEQKPVPGGPA SSSVFEFPSGQAFLVGHLQN LRLDSGPSPASPLSSISAPN STDATHLKFHPVFVPHSAPA VLTNSNENRSNCVFEFHAQT PSSSGEGGGILPQRVYRNRQ VAVDSNQEELSPQSVGLHCH LQPVTEEQRNNHAPELTISV VEPMGQIWPIGSPEYSSDSS QITSSDLSDFQSPPPTGGTA APFGSDVSLPFIRLPQTVLQ ESPLFFCFPQGTTSQQVLSA SYSSGGSTLHPQAQGQNQGQ PSSSLAGVLSSQPIQHPQQQ GIQPTVPSQQAVQYSLPQAA SSSEGTTAQPVSQPQVSAGT in isoform 3. CuratedAdd BLAST	222
Alternative sequenceⁱVSP_040273	784 – 1032	Missing in isoform 4. 1 PublicationAdd BLAST	249
Alternative sequenceⁱVSP_040274	784 – 937	Missing in isoform 5. 1 PublicationAdd BLAST	154
Alternative sequenceⁱVSP_040275	784 – 788	LPVSQ → VNSNF in isoform 6. 1 Publication	5
Alternative sequenceⁱVSP_040276	789 – 2377	Missing in isoform 6. 1 PublicationAdd BLAST	1589
Alternative sequenceⁱVSP_040277	1787 – 1814	Missing in isoform 5. 1 PublicationAdd BLAST	28

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY309076 mRNA Translation: AAQ77243.1 AY319934 mRNA Translation: AAQ84611.1 AK172935 mRNA Translation: BAD32213.1 Different initiation. AC113092 Genomic DNA No translation available. AC117667 Genomic DNA No translation available. BC056761 mRNA Translation: AAH56761.1 BC138445 mRNA Translation: AAI38446.1 BC145282 mRNA Translation: AAI45283.1 BC146009 mRNA Translation: AAI46010.1 Sequence problems. BC146011 mRNA Translation: AAI46012.1 Sequence problems. BC171955 mRNA Translation: AAI71955.1 AK133738 mRNA Translation: BAE21813.1 BK004107 Genomic DNA Translation: DAA04493.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20478.1 [P83741-1] CCDS51888.1 [P83741-5] CCDS57444.1 [P83741-3] CCDS57445.1 [P83741-2] CCDS85147.1 [P83741-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171949.1, NM_001185020.1 [P83741-4] NP_001171950.1, NM_001185021.1 [P83741-5] NP_001186012.1, NM_001199083.1 [P83741-2] NP_001186013.1, NM_001199084.1 [P83741-3] NP_941992.2, NM_198703.3 [P83741-1] XP_017177038.1, XM_017321549.1 [P83741-1] XP_017177043.1, XM_017321554.1 [P83741-5] XP_017177046.1, XM_017321557.1 [P83741-4]
UniGeneⁱ	Mm.333349

Genome annotation databases

Ensemblⁱ	ENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1] ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3] ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5] ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2] ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4]
GeneIDⁱ	232341
KEGGⁱ	mmu:232341
UCSC genome browser More...UCSCⁱ	uc009dmt.2 mouse [P83741-1] uc009dmu.2 mouse [P83741-5] uc009dmv.2 mouse [P83741-6] uc012ers.1 mouse [P83741-3] uc012ert.1 mouse [P83741-2] uc012eru.1 mouse [P83741-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P83741	Serine/threonine-protein kinase WNK1 (Fragment)		MOUSE		281	UniRef90_P83741
UPI00067E5027		MICOH		2414
UPI0004E486A9		RAT		2413
UPI000A308507		MUSPA		2380
UPI0003D71B7A		MOUSE		2415
+6
P83741-2	Isoform 2 of Serine/threonine-protein kinase WNK1		RAT		2625	UniRef90_Q9JIH7-3
UPI00042AB9ED		PERMB		2636
UPI000B4F2280		MERUN		2630
UPI00038C30BC		MICOH		2627
UPI000A307698		MUSPA		2625
+1
P83741-3	Isoform 3 of Serine/threonine-protein kinase WNK1		RAT		2634	UniRef90_Q9JIH7-2
Serine/threonine-protein kinase WNK1 (Fragment)		MOUSE		238
UPI00042ABF18		PERMB		2645
UPI0004ED4FDD		NANGA		2642
UPI000B4F4082		MERUN		2640
+4
P83741-4	Protein kinase lysine deficient 1		MOUSE		2131	UniRef90_P83741-4
UPI000B4ED100		MERUN		2132
UPI000A305A7F		MUSPA		2129
UPI00038BCD8D		MICOH		2128
UPI0007DA7DBA		CRIGR		2123
+3
P83741-7	Isoform 4 of Serine/threonine-protein kinase WNK1		RAT		160	UniRef90_Q9JIH7-4
Isoform 5 of Serine/threonine-protein kinase WNK1		RAT		135

Protein	Similar proteins		Species	Score	Length	Source
P83741	Serine/threonine-protein kinase WNK1	)	HUMAN		2382	UniRef50_Q9H4A3
Serine/threonine-protein kinase WNK1		PIG		2376
Uncharacterized protein		CERAT		2385
Uncharacterized protein		MACFA		2384
Uncharacterized protein		MACMU		2384
+820
P83741-2	Isoform 4 of Serine/threonine-protein kinase WNK1		HUMAN		2634	UniRef50_Q9H4A3-5
Serine/threonine-protein kinase WNK1	)	RAT		2126
WNK1 isoform 1		PANTR		2635
WNK1 isoform 1		PONAB		2635
Uncharacterized protein		MACMU		2631
+290
P83741-4	Isoform 2 of Serine/threonine-protein kinase WNK1		HUMAN		2135	UniRef50_Q9H4A3-2
serine/threonine-protein kinase WNK1 isoform X3		Enhydra lutris kenyoni		2140
WNK lysine deficient protein kinase 1		PANTR		2136
Uncharacterized protein		NOMLE		2136
Serine/threonine-protein kinase WNK1 isoform 2		CALJA		2134
+134
P83741-5	Isoform 3 of Serine/threonine-protein kinase WNK1		HUMAN		1975	UniRef50_Q9H4A3-4
Serine/threonine-protein kinase WNK1 isoform D		Patagioenas fasciata monilis		2148
Serine/threonine-protein kinase WNK1 (Fragment)		TINGU		1937
WNK lysine deficient protein kinase 1		CAVPO		2267
serine/threonine-protein kinase WNK1 isoform X4		PHYCD		2339
+38
P83741-6	Serine/threonine-protein kinase WNK1		FUKDA		749	UniRef50_P83741-6
Uncharacterized protein (Fragment)		BAMTH		895
Uncharacterized protein		CALSU		781
UPI000981389E		CASCN		668
P83741-7	Isoform 4 of Serine/threonine-protein kinase WNK1		RAT		160	UniRef50_Q9JIH7-4
Isoform 5 of Serine/threonine-protein kinase WNK1		RAT		135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY309076 mRNA Translation: AAQ77243.1 AY319934 mRNA Translation: AAQ84611.1 AK172935 mRNA Translation: BAD32213.1 Different initiation. AC113092 Genomic DNA No translation available. AC117667 Genomic DNA No translation available. BC056761 mRNA Translation: AAH56761.1 BC138445 mRNA Translation: AAI38446.1 BC145282 mRNA Translation: AAI45283.1 BC146009 mRNA Translation: AAI46010.1 Sequence problems. BC146011 mRNA Translation: AAI46012.1 Sequence problems. BC171955 mRNA Translation: AAI71955.1 AK133738 mRNA Translation: BAE21813.1 BK004107 Genomic DNA Translation: DAA04493.1 Sequence problems.
CCDSⁱ	CCDS20478.1 [P83741-1] CCDS51888.1 [P83741-5] CCDS57444.1 [P83741-3] CCDS57445.1 [P83741-2] CCDS85147.1 [P83741-4]
RefSeqⁱ	NP_001171949.1, NM_001185020.1 [P83741-4] NP_001171950.1, NM_001185021.1 [P83741-5] NP_001186012.1, NM_001199083.1 [P83741-2] NP_001186013.1, NM_001199084.1 [P83741-3] NP_941992.2, NM_198703.3 [P83741-1] XP_017177038.1, XM_017321549.1 [P83741-1] XP_017177043.1, XM_017321554.1 [P83741-5] XP_017177046.1, XM_017321557.1 [P83741-4]
UniGeneⁱ	Mm.333349

3D structure databases

ProteinModelPortalⁱ	P83741
SMRⁱ	P83741
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231244, 1 interactor
STRINGⁱ	10090.ENSMUSP00000086017

Chemistry databases

ChEMBLⁱ	CHEMBL2176799

ChEMBLⁱ

CHEMBL2176799

PTM databases

iPTMnetⁱ	P83741
PhosphoSitePlusⁱ	P83741

Proteomic databases

MaxQBⁱ	P83741
PaxDbⁱ	P83741
PeptideAtlasⁱ	P83741
PRIDEⁱ	P83741

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1] ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3] ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5] ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2] ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4]
GeneIDⁱ	232341
KEGGⁱ	mmu:232341
UCSCⁱ	uc009dmt.2 mouse [P83741-1] uc009dmu.2 mouse [P83741-5] uc009dmv.2 mouse [P83741-6] uc012ers.1 mouse [P83741-3] uc012ert.1 mouse [P83741-2] uc012eru.1 mouse [P83741-4]

Organism-specific databases

CTDⁱ	65125
MGIⁱ	MGI:2442092 Wnk1

Phylogenomic databases

eggNOGⁱ	KOG0584 Eukaryota ENOG410XQWZ LUCA
GeneTreeⁱ	ENSGT00800000124049
HOVERGENⁱ	HBG079897
InParanoidⁱ	P83741
KOⁱ	K08867
OMAⁱ	TQVVHSA
OrthoDBⁱ	EOG091G06LL
PhylomeDBⁱ	P83741
TreeFamⁱ	TF315363

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2672351 Stimuli-sensing channels

Reactomeⁱ

R-MMU-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRSⁱ	Wnk1 mouse
Protein Ontology More...PROⁱ	PR:P83741
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000045962 Expressed in 329 organ(s), highest expression level in endothelial cell of lymphatic vessel
CleanExⁱ	MM_WNK1
ExpressionAtlasⁱ	P83741 baseline and differential
Genevisibleⁱ	P83741 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR024678 Kinase_OSR1/WNK_CCT IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF12202 OSR1_C, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WNK1_MOUSE
Accessionⁱ	P83741Primary (citable) accession number: P83741 Secondary accession number(s): A6H6V1 Q6VYA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	November 30, 2010
	Last modified:	October 10, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P83741 (WNK1_MOUSE)

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Serine/threonine-protein kinase WNK1

Wnk1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ