UniProtKB - P83741 (WNK1_MOUSE)
Serine/threonine-protein kinase WNK1
Wnk1
Functioni
Caution
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 231 | ATP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 351 | ATPBy similarity | 1 | |
Active sitei | 368 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 301 – 304 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATP binding Source: MGI
- chloride channel inhibitor activity Source: MGI
- magnesium ion binding Source: MGI
- phosphatase binding Source: UniProtKB
- potassium channel inhibitor activity Source: MGI
- protein kinase activator activity Source: MGI
- protein kinase activity Source: MGI
- protein kinase binding Source: MGI
- protein serine/threonine kinase activity Source: BHF-UCL
- protein serine/threonine kinase inhibitor activity Source: MGI
GO - Biological processi
- cellular response to calcium ion Source: MGI
- cellular response to chemokine Source: BHF-UCL
- chemokine (C-C motif) ligand 21 signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: MGI
- ion homeostasis Source: GO_Central
- ion transport Source: UniProtKB
- lymphocyte migration into lymph node Source: BHF-UCL
- negative regulation of cell-cell adhesion mediated by integrin Source: MGI
- negative regulation of GTPase activity Source: BHF-UCL
- negative regulation of heterotypic cell-cell adhesion Source: MGI
- negative regulation of kinase activity Source: MGI
- negative regulation of leukocyte cell-cell adhesion Source: MGI
- negative regulation of pancreatic juice secretion Source: MGI
- negative regulation of phosphatase activity Source: UniProtKB
- negative regulation of sodium ion transport Source: UniProtKB
- peptidyl-serine phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: ARUK-UCL
- positive regulation of canonical Wnt signaling pathway Source: MGI
- positive regulation of ion transmembrane transporter activity Source: GO_Central
- positive regulation of potassium ion import across plasma membrane Source: GO_Central
- positive regulation of sodium ion transmembrane transporter activity Source: GO_Central
- positive regulation of systemic arterial blood pressure Source: MGI
- positive regulation of T cell chemotaxis Source: MGI
- protein autophosphorylation Source: MGI
- protein phosphorylation Source: MGI
- regulation of cation transmembrane transport Source: MGI
- regulation of cellular process Source: UniProtKB
- regulation of sodium ion transport Source: UniProtKB
- signal transduction by trans-phosphorylation Source: MGI
- T cell receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase WNK1Curated (EC:2.7.11.1By similarity)Alternative name(s): Protein kinase lysine-deficient 1Imported Protein kinase with no lysine 11 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442092, Wnk1 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 368 | D → A: No effect on inhibition of SLC4A4. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL2176799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086820 | 1 – 2377 | Serine/threonine-protein kinase WNK1Add BLAST | 2377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 378 | Phosphoserine; by autocatalysisBy similarity | 1 | |
Modified residuei | 382 | Phosphoserine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1256 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1973 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2006 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2007 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2022 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2024 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2027 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2116 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2281 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2365 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2367 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P83741 |
MaxQBi | P83741 |
PaxDbi | P83741 |
PeptideAtlasi | P83741 |
PRIDEi | P83741 |
PTM databases
GlyConnecti | 2429, 1 N-Linked glycan (1 site) [P83741-2] |
iPTMneti | P83741 |
PhosphoSitePlusi | P83741 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000045962, Expressed in endothelial cell of lymphatic vessel and 343 other tissues |
ExpressionAtlasi | P83741, baseline and differential |
Genevisiblei | P83741, MM |
Interactioni
Subunit structurei
Interacts with SYT2.
Interacts with KLHL3, WNK3 and WNK4 (By similarity). Isoform 7:
Interacts with isoform 1 (By similarity).
By similarityGO - Molecular functioni
- phosphatase binding Source: UniProtKB
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 231244, 18 interactors |
IntActi | P83741, 1 interactor |
MINTi | P83741 |
STRINGi | 10090.ENSMUSP00000063001 |
Miscellaneous databases
RNActi | P83741, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 221 – 479 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 488 – 555 | Autoinhibitory domainBy similarityAdd BLAST | 68 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0584, Eukaryota |
GeneTreei | ENSGT00940000155474 |
HOGENOMi | CLU_000550_0_0_1 |
InParanoidi | P83741 |
OMAi | PEPNGMT |
PhylomeDBi | P83741 |
TreeFami | TF315363 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE
60 70 80 90 100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI
110 120 130 140 150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA
160 170 180 190 200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ
210 220 230 240 250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC
260 270 280 290 300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV
310 320 330 340 350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL
360 370 380 390 400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD
410 420 430 440 450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP
460 470 480 490 500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI
510 520 530 540 550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD
560 570 580 590 600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS
610 620 630 640 650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV
660 670 680 690 700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ
710 720 730 740 750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS
760 770 780 790 800
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQLPVSQTV ATVQGEPHIP
810 820 830 840 850
VSTQPSVVPV HSGAHFLPMG QPIPTSLLPQ YPVSQIPIST PHVSTAQTGF
860 870 880 890 900
SSVPITMAAG INQPLLTLAS SATASSIPGG SPVVPNQLPT LLQPVNQLQS
910 920 930 940 950
QVHPQLLQPT TVQSIGIPAN LGQAAEGPLP SGDVLYQGFP SRLPPQYPGD
960 970 980 990 1000
SNIAPSSNVA SVCIHSTVLA PPSMPTEALA TQGYFPTVVQ PYVESTPLVP
1010 1020 1030 1040 1050
MGSVGGQVQV SQPAVSLTQQ PPTTSSQQAV LESTQGVSQA APPEQTPITQ
1060 1070 1080 1090 1100
SQPTQPVPLV TSADSAHSDV ASGMSDGNEN APSSSGRHEG RTTKRHYRKS
1110 1120 1130 1140 1150
VRSRSRHEKT SRPKLRILNV SNKGDRVVEC QLETHNRKMV TFKFDLDGDN
1160 1170 1180 1190 1200
PEEIATIMVN NDFILAIERE SFVAQVREII EKADEMLSED VSVEPEGDQG
1210 1220 1230 1240 1250
LESLQGKDDY GFPGSQKLEG EFKQPIAVSS MPQQIGVPTS SLTQVVHSAG
1260 1270 1280 1290 1300
RRFIVSPVPE SRLRESKVFT SDISDPVVAS TSQAPGMNLS HSASSLSLQQ
1310 1320 1330 1340 1350
AFSELKHGQM TEGPNTAPPN FNHMAGPTFS PFLASIAGVQ TVAASTPSVS
1360 1370 1380 1390 1400
VPITSSPLND ISTSVMQSET ALPTEKGIVG VTTTSTGVVA SGGLTTMSVS
1410 1420 1430 1440 1450
ESPTSSSAVS SSTVPAVVTV STPSQPVQAS TSGSIASSTG SFPPGTFSTT
1460 1470 1480 1490 1500
TATTMGSVVA PDAKPPTVLL QQVASNTAGV AIVTSVSTTT PFPGMASQPS
1510 1520 1530 1540 1550
LPLSSSTSAP TLAETMVVSA HSLDKASHSS TAGLGLSFCA PSSSSSSGTA
1560 1570 1580 1590 1600
VSTSVSQPGM VHPLVISSAV VSTPGLPQPV VPTSTPLLPQ VPNIPPLVQP
1610 1620 1630 1640 1650
VVNVPAVQQT LIHSQPQPAL LPNQPHTHCP EMDADTQSKA PGIDDIKTLE
1660 1670 1680 1690 1700
EKLRSLFSEH SSSGTQHASV SLETPLVVET TVTPGITTTA VAPSKLMTST
1710 1720 1730 1740 1750
TSTCLPPTSL PLGAAGMPVM PVGTPGQVST PGTHASAPVG TATGVKPGTT
1760 1770 1780 1790 1800
PPKPTKTVVP PVGTELSAGT VPCEQLPPFP GPSLIQSQQP LEDLDAQLRR
1810 1820 1830 1840 1850
TLSPETITVA PAVGPLSTMS STTVTEAGTR LQKDGTEGHV TATSSGAGVV
1860 1870 1880 1890 1900
KMGRFQVSVT MDDAQKERKN RSEDTKSVHF ESSTSESSVL SSSSPESTLV
1910 1920 1930 1940 1950
KPEPNGISIS GISLDVPDST HKAPTPEAKS DAGQPTKVGR FQVTTTANKV
1960 1970 1980 1990 2000
GRFSVSRTED KVTELKKEGP VTSPPFRDSE QTVIPAVIPK KEKPELAEPS
2010 2020 2030 2040 2050
HLNGPSSDLE AAFLSRGTED GSGSPHSPPH LCSKSLPVQN LSQSLSNSFN
2060 2070 2080 2090 2100
SSYMSSDNES DIEDEDLRLE LRRLREKHLK EIQDLQSRQK HEIESLYTKL
2110 2120 2130 2140 2150
GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS PQLSGNLSGQ
2160 2170 2180 2190 2200
SGTSVLHPQQ TLHPAGNTPE TGHNQLLQPL KPSPSSDNLY SAFTSDGAIS
2210 2220 2230 2240 2250
VPSLSAPGQG TSSTNTVGGT VSSQAAQAQP PAMTSSRKGT FTDDLHKLVD
2260 2270 2280 2290 2300
NWARDAMNLS GRRGSKGHMN YEGPGMARKF SAPGQLCVPM TSNLGGSTPI
2310 2320 2330 2340 2350
SAASATSLGH FTKSMCPPQQ YGFPPAPFGT QWSGTGGPAP QPLGQFQPVG
2360 2370
TASLQNFNIS NLQKSISNPP GSNLRTT
The sequence of this isoform differs from the canonical sequence as follows:
715-1032: AQGQNQGQPS...TTSSQQAVLE → PRRGRSMSVC...SQPQVSAGTQ
The sequence of this isoform differs from the canonical sequence as follows:
715-936: AQGQNQGQPS...GPLPSGDVLY → PQSMAHPCGG...VSQPQVSAGT
The sequence of this isoform differs from the canonical sequence as follows:
1-437: MSDGAAEKQS...AAQIYRRVTS → MDFMKKDFCSVFVIVNSHCCCCSQKDCINE
543-2377: Missing.
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7CC62 | F7CC62_MOUSE | Non-specific serine/threonine prote... | Wnk1 | 405 | Annotation score: | ||
A0A0R4J274 | A0A0R4J274_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 433 | Annotation score: | ||
F6U2S8 | F6U2S8_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 281 | Annotation score: | ||
F6TAR7 | F6TAR7_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 200 | Annotation score: | ||
F7CZC4 | F7CZC4_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 407 | Annotation score: | ||
J3QPK0 | J3QPK0_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 238 | Annotation score: | ||
F6TW99 | F6TW99_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 252 | Annotation score: | ||
F7CBK9 | F7CBK9_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 213 | Annotation score: | ||
F6S7V4 | F6S7V4_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 85 | Annotation score: | ||
F7B663 | F7B663_MOUSE | Serine/threonine-protein kinase WNK... | Wnk1 | 67 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1220 | G → R in AAQ77243 (PubMed:14514722).Curated | 1 | |
Sequence conflicti | 1230 | S → C in AAQ77243 (PubMed:14514722).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058592 | 1 – 437 | MSDGA…RRVTS → MDFMKKDFCSVFVIVNSHCC CCSQKDCINE in isoform 7. Add BLAST | 437 | |
Alternative sequenceiVSP_058593 | 543 – 2377 | Missing in isoform 7. Add BLAST | 1835 | |
Alternative sequenceiVSP_040271 | 715 – 1032 | AQGQN…QAVLE → PRRGRSMSVCVPHLSAVPSL SRISPSAPSTPPPVLSAPLC PSLLRTAPEETFAEKLSKAL ESVLPMHSASQRKHRRSSLP SLFVTTPQSMAHPCGGTPTY PESQIFFPTIHERPVSFSPP PTCPPKVAISQRRKSTSFLE AQTRHFQPLLRTVGQNHLPP GSSPTNWTPEAIVMLGATAN RVNRELCEMQVQPVFEPTQI YSDYRPGLVLAEEAHYFIPQ ETVYLAGVHYQAQVAGQYEG ISYNSPVLSSPMKQISEQKP VPGGPASSSVFEFPSGQAFL VGHLQNLRLDSGPSPASPLS SISAPNSTDATHLKFHPVFV PHSAPAVLTNSNENRSNCVF EFHAQTPSSSGEGGGILPQR VYRNRQVAVDSNQEELSPQS VGLHCHLQPVTEEQRNNHAP ELTISVVEPMGQIWPIGSPE YSSDSSQITSSDLSDFQSPP PTGGTAAPFGSDVSLPFIRL PQTVLQESPLFFCFPQGTTS QQVLSASYSSGGSTLHPQAQ GQNQGQPSSSLAGVLSSQPI QHPQQQGIQPTVPSQQAVQY SLPQAASSSEGTTAQPVSQP QVSAGTQ in isoform 2. CuratedAdd BLAST | 318 | |
Alternative sequenceiVSP_040272 | 715 – 936 | AQGQN…GDVLY → PQSMAHPCGGTPTYPESQIF FPTIHERPVSFSPPPTCPPK VAISQRRKSTSFLEAQTRHF QPLLRTVGQNHLPPGSSPTN WTPEAIVMLGATANRVNREL CEMQVQPVFEPTQIYSDYRP GLVLAEEAHYFIPQETVYLA GVHYQAQVAGQYEGISYNSP VLSSPMKQISEQKPVPGGPA SSSVFEFPSGQAFLVGHLQN LRLDSGPSPASPLSSISAPN STDATHLKFHPVFVPHSAPA VLTNSNENRSNCVFEFHAQT PSSSGEGGGILPQRVYRNRQ VAVDSNQEELSPQSVGLHCH LQPVTEEQRNNHAPELTISV VEPMGQIWPIGSPEYSSDSS QITSSDLSDFQSPPPTGGTA APFGSDVSLPFIRLPQTVLQ ESPLFFCFPQGTTSQQVLSA SYSSGGSTLHPQAQGQNQGQ PSSSLAGVLSSQPIQHPQQQ GIQPTVPSQQAVQYSLPQAA SSSEGTTAQPVSQPQVSAGT in isoform 3. CuratedAdd BLAST | 222 | |
Alternative sequenceiVSP_040273 | 784 – 1032 | Missing in isoform 4. 1 PublicationAdd BLAST | 249 | |
Alternative sequenceiVSP_040274 | 784 – 937 | Missing in isoform 5. 1 PublicationAdd BLAST | 154 | |
Alternative sequenceiVSP_040275 | 784 – 788 | LPVSQ → VNSNF in isoform 6. 1 Publication | 5 | |
Alternative sequenceiVSP_040276 | 789 – 2377 | Missing in isoform 6. 1 PublicationAdd BLAST | 1589 | |
Alternative sequenceiVSP_040277 | 1787 – 1814 | Missing in isoform 5. 1 PublicationAdd BLAST | 28 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1] ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3] ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5] ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2] ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4] |
GeneIDi | 232341 |
KEGGi | mmu:232341 |
UCSCi | uc009dmt.2, mouse [P83741-1] uc009dmu.2, mouse [P83741-5] uc009dmv.2, mouse [P83741-6] uc012ers.1, mouse [P83741-3] uc012ert.1, mouse [P83741-2] uc012eru.1, mouse [P83741-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
BMRBi | P83741 |
SMRi | P83741 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231244, 18 interactors |
IntActi | P83741, 1 interactor |
MINTi | P83741 |
STRINGi | 10090.ENSMUSP00000063001 |
Chemistry databases
ChEMBLi | CHEMBL2176799 |
PTM databases
GlyConnecti | 2429, 1 N-Linked glycan (1 site) [P83741-2] |
iPTMneti | P83741 |
PhosphoSitePlusi | P83741 |
Proteomic databases
jPOSTi | P83741 |
MaxQBi | P83741 |
PaxDbi | P83741 |
PeptideAtlasi | P83741 |
PRIDEi | P83741 |
Protocols and materials databases
Antibodypediai | 22083, 586 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1] ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3] ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5] ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2] ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4] |
GeneIDi | 232341 |
KEGGi | mmu:232341 |
UCSCi | uc009dmt.2, mouse [P83741-1] uc009dmu.2, mouse [P83741-5] uc009dmv.2, mouse [P83741-6] uc012ers.1, mouse [P83741-3] uc012ert.1, mouse [P83741-2] uc012eru.1, mouse [P83741-4] |
Organism-specific databases
CTDi | 65125 |
MGIi | MGI:2442092, Wnk1 |
Phylogenomic databases
eggNOGi | KOG0584, Eukaryota |
GeneTreei | ENSGT00940000155474 |
HOGENOMi | CLU_000550_0_0_1 |
InParanoidi | P83741 |
OMAi | PEPNGMT |
PhylomeDBi | P83741 |
TreeFami | TF315363 |
Enzyme and pathway databases
Reactomei | R-MMU-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 232341, 7 hits in 21 CRISPR screens |
ChiTaRSi | Wnk1, mouse |
PROi | PR:P83741 |
RNActi | P83741, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045962, Expressed in endothelial cell of lymphatic vessel and 343 other tissues |
ExpressionAtlasi | P83741, baseline and differential |
Genevisiblei | P83741, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024678, Kinase_OSR1/WNK_CCT IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12202, OSR1_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WNK1_MOUSE | |
Accessioni | P83741Primary (citable) accession number: P83741 Secondary accession number(s): A6H6V1 Q6VYA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index