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UniProtKB - P83741 (WNK1_MOUSE)

Entry version 169 (07 Oct 2020)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

Serine/threonine-protein kinase WNK1

Gene

Wnk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (PubMed:21317537, PubMed:23542070).3 Publications
Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.By similarity

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity
It is uncertain whether Met-1 or Met-214 is the initiator.Curated
HSN2 was originally thought to be an intronless gene lying within a WNK1 gene intron. It has been shown to be a nervous system-specific exon of WNK1 included in isoform 2 and isoform 3 (PubMed:18521183).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

By hypertonicity. Activation requires autophosphorylation of Ser-382. Phosphorylation of Ser-378 also promotes increased activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei231ATP; via amide nitrogenBy similarity1
Binding sitei351ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei368Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi301 – 304ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2672351, Stimuli-sensing channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK1Curated (EC:2.7.11.1By similarity)
Alternative name(s):
Protein kinase lysine-deficient 1Imported
Protein kinase with no lysine 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wnk1Imported
Synonyms:Hsn21 Publication, Prkwnk1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2442092, Wnk1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi368D → A: No effect on inhibition of SLC4A4. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2176799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868201 – 2377Serine/threonine-protein kinase WNK1Add BLAST2377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphothreonineCombined sources1
Modified residuei165PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei378Phosphoserine; by autocatalysisBy similarity1
Modified residuei382Phosphoserine; by autocatalysisBy similarity1
Modified residuei1256PhosphoserineBy similarity1
Modified residuei1973PhosphoserineBy similarity1
Modified residuei2006PhosphoserineBy similarity1
Modified residuei2007PhosphoserineBy similarity1
Modified residuei2022PhosphoserineBy similarity1
Modified residuei2024PhosphoserineBy similarity1
Modified residuei2027PhosphoserineCombined sources1
Modified residuei2116PhosphoserineBy similarity1
Modified residuei2265PhosphoserineCombined sources1
Modified residuei2281PhosphoserineCombined sources1
Modified residuei2365PhosphoserineBy similarity1
Modified residuei2367PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation at Ser-382 is inhibited by intracellular calcium.By similarity
Ubiquitinated in vitro by the BCR(KLHL3) complex and in vivo by a BCR(KLHL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P83741

MaxQB - The MaxQuant DataBase

More...MaxQBi		P83741

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P83741

PeptideAtlas

More...PeptideAtlasi		P83741

PRoteomics IDEntifications database

More...PRIDEi		P83741

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2429, 1 N-Linked glycan (1 site) [P83741-2]

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P83741

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P83741

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in both adult and embryonic tissue, with highest levels observed in the testis and lower levels in heart, lung, kidney, placenta, brain and skeletal muscle. Expressed in pancreatic duct (PubMed:21317537). Two isoforms are expressed in heart, a single shorter isoform in the kidney. Locates to the distal convoluted tubule, the medullary collecting duct and the cortical collecting duct of the kidney. HSN2-containing isoform 2 and isoform 3 are restricted to the nervous system, expressed preferentially in sensory neurons than in motor neurons and in general more abundant in axons than in cell bodies (at protein level). In the DRG, predominantly expressed in the satellite cells that envelop sensory neurons, but low expression also observed in the cell bodies of neurons (at protein level). In the sciatic nerve, expressed in the Schwann cells that surround axons and in a mosaic distribution of axons (at protein level). In the spinal cord, expressed in superficial layers (LI and LII), as well as in the fibers of the Lissauer tract (at protein level). Also detected in the axon fibers of dorsolateral funiculus and lateral funiculus (at protein level).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000045962, Expressed in endothelial cell of lymphatic vessel and 343 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P83741, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P83741, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYT2.

Interacts with KLHL3, WNK3 and WNK4 (By similarity). Isoform 7:

Interacts with isoform 1 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		231244, 18 interactors

Protein interaction database and analysis system

More...IntActi		P83741, 1 interactor

Molecular INTeraction database

More...MINTi		P83741

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000063001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P83741, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P83741

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P83741

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 479Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni488 – 555Autoinhibitory domainBy similarityAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0584, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155474

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000550_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P83741

KEGG Orthology (KO)

More...KOi		K08867

Identification of Orthologs from Complete Genome Data

More...OMAi		PEPNGMT

Database for complete collections of gene phylogenies

More...PhylomeDBi		P83741

TreeFam database of animal gene trees

More...TreeFami		TF315363

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P83741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDGAAEKQS GTPGFLTPPA PVPKNGSSSD SSVGEKLGAT VADSGVGRTE 
        60         70         80         90        100
EYRRRRHTMD KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI 
       110        120        130        140        150
PQPSVPAVVP QSAPPEPHRE ETLTATVASQ VSQQPSAAAS PGEQAVVGSA 
       160        170        180        190        200
TTTVPSSTSK DRPVSQPSLV GSKEEPPPSR SGSGSGGASA KEAQEDRSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 
       610        620        630        640        650
QAGIQQLSAA STGIPTAPAT SASVSTQVEP EEPEADQHQQ LQYQQPSISV 
       660        670        680        690        700
LSDGTIDSGQ GSSVFTESRV SSQQTVSYGS QHEQAHSTGT APGHTVSSIQ 
       710        720        730        740        750
AQSQPHGVYP PSSMAQGQNQ GQPSSSLAGV LSSQPIQHPQ QQGIQPTVPS 
       760        770        780        790        800
QQAVQYSLPQ AASSSEGTTA QPVSQPQVSA GTQLPVSQTV ATVQGEPHIP 
       810        820        830        840        850
VSTQPSVVPV HSGAHFLPMG QPIPTSLLPQ YPVSQIPIST PHVSTAQTGF 
       860        870        880        890        900
SSVPITMAAG INQPLLTLAS SATASSIPGG SPVVPNQLPT LLQPVNQLQS 
       910        920        930        940        950
QVHPQLLQPT TVQSIGIPAN LGQAAEGPLP SGDVLYQGFP SRLPPQYPGD 
       960        970        980        990       1000
SNIAPSSNVA SVCIHSTVLA PPSMPTEALA TQGYFPTVVQ PYVESTPLVP 
      1010       1020       1030       1040       1050
MGSVGGQVQV SQPAVSLTQQ PPTTSSQQAV LESTQGVSQA APPEQTPITQ 
      1060       1070       1080       1090       1100
SQPTQPVPLV TSADSAHSDV ASGMSDGNEN APSSSGRHEG RTTKRHYRKS 
      1110       1120       1130       1140       1150
VRSRSRHEKT SRPKLRILNV SNKGDRVVEC QLETHNRKMV TFKFDLDGDN 
      1160       1170       1180       1190       1200
PEEIATIMVN NDFILAIERE SFVAQVREII EKADEMLSED VSVEPEGDQG 
      1210       1220       1230       1240       1250
LESLQGKDDY GFPGSQKLEG EFKQPIAVSS MPQQIGVPTS SLTQVVHSAG 
      1260       1270       1280       1290       1300
RRFIVSPVPE SRLRESKVFT SDISDPVVAS TSQAPGMNLS HSASSLSLQQ 
      1310       1320       1330       1340       1350
AFSELKHGQM TEGPNTAPPN FNHMAGPTFS PFLASIAGVQ TVAASTPSVS 
      1360       1370       1380       1390       1400
VPITSSPLND ISTSVMQSET ALPTEKGIVG VTTTSTGVVA SGGLTTMSVS 
      1410       1420       1430       1440       1450
ESPTSSSAVS SSTVPAVVTV STPSQPVQAS TSGSIASSTG SFPPGTFSTT 
      1460       1470       1480       1490       1500
TATTMGSVVA PDAKPPTVLL QQVASNTAGV AIVTSVSTTT PFPGMASQPS 
      1510       1520       1530       1540       1550
LPLSSSTSAP TLAETMVVSA HSLDKASHSS TAGLGLSFCA PSSSSSSGTA 
      1560       1570       1580       1590       1600
VSTSVSQPGM VHPLVISSAV VSTPGLPQPV VPTSTPLLPQ VPNIPPLVQP 
      1610       1620       1630       1640       1650
VVNVPAVQQT LIHSQPQPAL LPNQPHTHCP EMDADTQSKA PGIDDIKTLE 
      1660       1670       1680       1690       1700
EKLRSLFSEH SSSGTQHASV SLETPLVVET TVTPGITTTA VAPSKLMTST 
      1710       1720       1730       1740       1750
TSTCLPPTSL PLGAAGMPVM PVGTPGQVST PGTHASAPVG TATGVKPGTT 
      1760       1770       1780       1790       1800
PPKPTKTVVP PVGTELSAGT VPCEQLPPFP GPSLIQSQQP LEDLDAQLRR 
      1810       1820       1830       1840       1850
TLSPETITVA PAVGPLSTMS STTVTEAGTR LQKDGTEGHV TATSSGAGVV 
      1860       1870       1880       1890       1900
KMGRFQVSVT MDDAQKERKN RSEDTKSVHF ESSTSESSVL SSSSPESTLV 
      1910       1920       1930       1940       1950
KPEPNGISIS GISLDVPDST HKAPTPEAKS DAGQPTKVGR FQVTTTANKV 
      1960       1970       1980       1990       2000
GRFSVSRTED KVTELKKEGP VTSPPFRDSE QTVIPAVIPK KEKPELAEPS 
      2010       2020       2030       2040       2050
HLNGPSSDLE AAFLSRGTED GSGSPHSPPH LCSKSLPVQN LSQSLSNSFN 
      2060       2070       2080       2090       2100
SSYMSSDNES DIEDEDLRLE LRRLREKHLK EIQDLQSRQK HEIESLYTKL 
      2110       2120       2130       2140       2150
GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS PQLSGNLSGQ 
      2160       2170       2180       2190       2200
SGTSVLHPQQ TLHPAGNTPE TGHNQLLQPL KPSPSSDNLY SAFTSDGAIS 
      2210       2220       2230       2240       2250
VPSLSAPGQG TSSTNTVGGT VSSQAAQAQP PAMTSSRKGT FTDDLHKLVD 
      2260       2270       2280       2290       2300
NWARDAMNLS GRRGSKGHMN YEGPGMARKF SAPGQLCVPM TSNLGGSTPI 
      2310       2320       2330       2340       2350
SAASATSLGH FTKSMCPPQQ YGFPPAPFGT QWSGTGGPAP QPLGQFQPVG 
      2360       2370 
TASLQNFNIS NLQKSISNPP GSNLRTT
Length:2,377
Mass (Da):250,934
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C4D288CCE50B8C6
GO
Isoform 2 (identifier: P83741-2) [UniParc]FASTAAdd to basket
Also known as: Brain and spinal cord variant

The sequence of this isoform differs from the canonical sequence as follows:
     715-1032: AQGQNQGQPS...TTSSQQAVLE → PRRGRSMSVC...SQPQVSAGTQ

Note: This isoform which includes the HSN2 exon has been identified in human and mouse. The sequence shown here is the result of gene prediction.Curated
Show »
Length:2,626
Mass (Da):279,185
Checksum:i1933C3D136EE2103
GO
Isoform 3 (identifier: P83741-3) [UniParc]FASTAAdd to basket
Also known as: Dorsal root ganglia and sciatic nerve variant, DRG and sciatic nerve variant

The sequence of this isoform differs from the canonical sequence as follows:
     715-936: AQGQNQGQPS...GPLPSGDVLY → PQSMAHPCGG...VSQPQVSAGT

Note: This isoform which includes the HSN2 exon has been identified in human and mouse. The sequence shown here is the result of gene prediction.Curated
Show »
Length:2,635
Mass (Da):279,763
Checksum:i8E2B08C9DCB624BF
GO
Isoform 4 (identifier: P83741-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-1032: Missing.

Show »
Length:2,128
Mass (Da):225,405
Checksum:iA414E93D815771CE
GO
Isoform 5 (identifier: P83741-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-937: Missing.
     1787-1814: Missing.

Show »
Length:2,195
Mass (Da):232,203
Checksum:i43A9B0F75D83925D
GO
Isoform 6 (identifier: P83741-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-788: LPVSQ → VNSNF
     789-2377: Missing.

Note: May be due to intron retention.Curated
Show »
Length:788
Mass (Da):86,037
Checksum:i75A4C9BD9B35580E
GO
Isoform 7 (identifier: P83741-7) [UniParc]FASTAAdd to basket
Also known as: KS-WNK1, Kidney-Specific1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: MSDGAAEKQS...AAQIYRRVTS → MDFMKKDFCSVFVIVNSHCCCCSQKDCINE
     543-2377: Missing.

Note: Kinase-defective isoform. Produced by alternative promoter usage and alternative splicing.1 Publication
Show »
Length:135
Mass (Da):15,643
Checksum:i652F45351044FFE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CC62F7CC62_MOUSE
Non-specific serine/threonine prote...
Wnk1
405Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J274A0A0R4J274_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U2S8F6U2S8_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TAR7F6TAR7_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CZC4F7CZC4_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QPK0J3QPK0_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TW99F6TW99_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CBK9F7CBK9_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S7V4F6S7V4_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B663F7B663_MOUSE
Serine/threonine-protein kinase WNK...
Wnk1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI46010 differs from that shown. Probable cloning artifact.Curated
The sequence AAI46012 differs from that shown. Probable cloning artifact.Curated
The sequence BAD32213 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence DAA04493 differs from that shown. Reason: Erroneous gene model prediction. Includes 3' and 3' intronic sequences.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1220G → R in AAQ77243 (PubMed:14514722).Curated1
Sequence conflicti1230S → C in AAQ77243 (PubMed:14514722).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585921 – 437MSDGA…RRVTS → MDFMKKDFCSVFVIVNSHCC CCSQKDCINE in isoform 7. Add BLAST437
Alternative sequenceiVSP_058593543 – 2377Missing in isoform 7. Add BLAST1835
Alternative sequenceiVSP_040271715 – 1032AQGQN…QAVLE → PRRGRSMSVCVPHLSAVPSL SRISPSAPSTPPPVLSAPLC PSLLRTAPEETFAEKLSKAL ESVLPMHSASQRKHRRSSLP SLFVTTPQSMAHPCGGTPTY PESQIFFPTIHERPVSFSPP PTCPPKVAISQRRKSTSFLE AQTRHFQPLLRTVGQNHLPP GSSPTNWTPEAIVMLGATAN RVNRELCEMQVQPVFEPTQI YSDYRPGLVLAEEAHYFIPQ ETVYLAGVHYQAQVAGQYEG ISYNSPVLSSPMKQISEQKP VPGGPASSSVFEFPSGQAFL VGHLQNLRLDSGPSPASPLS SISAPNSTDATHLKFHPVFV PHSAPAVLTNSNENRSNCVF EFHAQTPSSSGEGGGILPQR VYRNRQVAVDSNQEELSPQS VGLHCHLQPVTEEQRNNHAP ELTISVVEPMGQIWPIGSPE YSSDSSQITSSDLSDFQSPP PTGGTAAPFGSDVSLPFIRL PQTVLQESPLFFCFPQGTTS QQVLSASYSSGGSTLHPQAQ GQNQGQPSSSLAGVLSSQPI QHPQQQGIQPTVPSQQAVQY SLPQAASSSEGTTAQPVSQP QVSAGTQ in isoform 2. CuratedAdd BLAST318
Alternative sequenceiVSP_040272715 – 936AQGQN…GDVLY → PQSMAHPCGGTPTYPESQIF FPTIHERPVSFSPPPTCPPK VAISQRRKSTSFLEAQTRHF QPLLRTVGQNHLPPGSSPTN WTPEAIVMLGATANRVNREL CEMQVQPVFEPTQIYSDYRP GLVLAEEAHYFIPQETVYLA GVHYQAQVAGQYEGISYNSP VLSSPMKQISEQKPVPGGPA SSSVFEFPSGQAFLVGHLQN LRLDSGPSPASPLSSISAPN STDATHLKFHPVFVPHSAPA VLTNSNENRSNCVFEFHAQT PSSSGEGGGILPQRVYRNRQ VAVDSNQEELSPQSVGLHCH LQPVTEEQRNNHAPELTISV VEPMGQIWPIGSPEYSSDSS QITSSDLSDFQSPPPTGGTA APFGSDVSLPFIRLPQTVLQ ESPLFFCFPQGTTSQQVLSA SYSSGGSTLHPQAQGQNQGQ PSSSLAGVLSSQPIQHPQQQ GIQPTVPSQQAVQYSLPQAA SSSEGTTAQPVSQPQVSAGT in isoform 3. CuratedAdd BLAST222
Alternative sequenceiVSP_040273784 – 1032Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_040274784 – 937Missing in isoform 5. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_040275784 – 788LPVSQ → VNSNF in isoform 6. 1 Publication5
Alternative sequenceiVSP_040276789 – 2377Missing in isoform 6. 1 PublicationAdd BLAST1589
Alternative sequenceiVSP_0402771787 – 1814Missing in isoform 5. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY309076 mRNA Translation: AAQ77243.1
AY319934 mRNA Translation: AAQ84611.1
AK172935 mRNA Translation: BAD32213.1 Different initiation.
AC113092 Genomic DNA No translation available.
AC117667 Genomic DNA No translation available.
BC056761 mRNA Translation: AAH56761.1
BC138445 mRNA Translation: AAI38446.1
BC145282 mRNA Translation: AAI45283.1
BC146009 mRNA Translation: AAI46010.1 Sequence problems.
BC146011 mRNA Translation: AAI46012.1 Sequence problems.
BC171955 mRNA Translation: AAI71955.1
AK133738 mRNA Translation: BAE21813.1
BK004107 Genomic DNA Translation: DAA04493.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20478.1 [P83741-1]
CCDS51888.1 [P83741-5]
CCDS57444.1 [P83741-3]
CCDS57445.1 [P83741-2]
CCDS85147.1 [P83741-4]

NCBI Reference Sequences

More...RefSeqi		NP_001171949.1, NM_001185020.1 [P83741-4]
NP_001171950.1, NM_001185021.1 [P83741-5]
NP_001186012.1, NM_001199083.1 [P83741-2]
NP_001186013.1, NM_001199084.1 [P83741-3]
NP_941992.2, NM_198703.3 [P83741-1]
XP_017177038.1, XM_017321549.1 [P83741-1]
XP_017177043.1, XM_017321554.1 [P83741-5]
XP_017177046.1, XM_017321557.1 [P83741-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1]
ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3]
ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5]
ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2]
ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		232341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:232341

UCSC genome browser

More...UCSCi		uc009dmt.2, mouse [P83741-1]
uc009dmu.2, mouse [P83741-5]
uc009dmv.2, mouse [P83741-6]
uc012ers.1, mouse [P83741-3]
uc012ert.1, mouse [P83741-2]
uc012eru.1, mouse [P83741-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY309076 mRNA Translation: AAQ77243.1
AY319934 mRNA Translation: AAQ84611.1
AK172935 mRNA Translation: BAD32213.1 Different initiation.
AC113092 Genomic DNA No translation available.
AC117667 Genomic DNA No translation available.
BC056761 mRNA Translation: AAH56761.1
BC138445 mRNA Translation: AAI38446.1
BC145282 mRNA Translation: AAI45283.1
BC146009 mRNA Translation: AAI46010.1 Sequence problems.
BC146011 mRNA Translation: AAI46012.1 Sequence problems.
BC171955 mRNA Translation: AAI71955.1
AK133738 mRNA Translation: BAE21813.1
BK004107 Genomic DNA Translation: DAA04493.1 Sequence problems.
CCDSiCCDS20478.1 [P83741-1]
CCDS51888.1 [P83741-5]
CCDS57444.1 [P83741-3]
CCDS57445.1 [P83741-2]
CCDS85147.1 [P83741-4]
RefSeqiNP_001171949.1, NM_001185020.1 [P83741-4]
NP_001171950.1, NM_001185021.1 [P83741-5]
NP_001186012.1, NM_001199083.1 [P83741-2]
NP_001186013.1, NM_001199084.1 [P83741-3]
NP_941992.2, NM_198703.3 [P83741-1]
XP_017177038.1, XM_017321549.1 [P83741-1]
XP_017177043.1, XM_017321554.1 [P83741-5]
XP_017177046.1, XM_017321557.1 [P83741-4]

3D structure databases

BMRBiP83741
SMRiP83741
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231244, 18 interactors
IntActiP83741, 1 interactor
MINTiP83741
STRINGi10090.ENSMUSP00000063001

Chemistry databases

ChEMBLiCHEMBL2176799

PTM databases

GlyConnecti2429, 1 N-Linked glycan (1 site) [P83741-2]
iPTMnetiP83741
PhosphoSitePlusiP83741

Proteomic databases

jPOSTiP83741
MaxQBiP83741
PaxDbiP83741
PeptideAtlasiP83741
PRIDEiP83741

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22083, 586 antibodies

Genome annotation databases

EnsembliENSMUST00000060043; ENSMUSP00000063001; ENSMUSG00000045962 [P83741-1]
ENSMUST00000088644; ENSMUSP00000086017; ENSMUSG00000045962 [P83741-3]
ENSMUST00000088646; ENSMUSP00000086019; ENSMUSG00000045962 [P83741-5]
ENSMUST00000177761; ENSMUSP00000136777; ENSMUSG00000045962 [P83741-2]
ENSMUST00000203030; ENSMUSP00000145304; ENSMUSG00000045962 [P83741-4]
GeneIDi232341
KEGGimmu:232341
UCSCiuc009dmt.2, mouse [P83741-1]
uc009dmu.2, mouse [P83741-5]
uc009dmv.2, mouse [P83741-6]
uc012ers.1, mouse [P83741-3]
uc012ert.1, mouse [P83741-2]
uc012eru.1, mouse [P83741-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		65125
MGIiMGI:2442092, Wnk1

Phylogenomic databases

eggNOGiKOG0584, Eukaryota
GeneTreeiENSGT00940000155474
HOGENOMiCLU_000550_0_0_1
InParanoidiP83741
KOiK08867
OMAiPEPNGMT
PhylomeDBiP83741
TreeFamiTF315363

Enzyme and pathway databases

ReactomeiR-MMU-2672351, Stimuli-sensing channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		232341, 7 hits in 24 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Wnk1, mouse

Protein Ontology

More...PROi		PR:P83741
RNActiP83741, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000045962, Expressed in endothelial cell of lymphatic vessel and 343 other tissues
ExpressionAtlasiP83741, baseline and differential
GenevisibleiP83741, MM

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83741
Secondary accession number(s): A6H6V1
, B2RRJ7, B7ZNJ4, Q3UZP3, Q6A083, Q6IFS6, Q6VYA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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