UniProtKB - P83620 (TXC1B_CUPSA)
Protein
Cupiennin-1b
Gene
N/A
Organism
Cupiennius salei (American wandering spider)
Status
Functioni
Has antimicrobial activity against E.coli, E.faecalis, P.aeruginosa, and S.aureus. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane function with its amphipathic structure.1 Publication1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
- hemolysis in other organism Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Neurotoxin, Toxin |
Biological process | Cytolysis, Hemolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Cupiennin-1b1 PublicationShort name: Cu-1bCurated Alternative name(s): M-ctenitoxin-Cs1b Short name: M-CNTX-Cs1b |
Organismi | Cupiennius salei (American wandering spider)Curated |
Taxonomic identifieri | 6928 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Araneomorphae › Entelegynae › Lycosoidea › Ctenidae › Cupiennius |
Organism-specific databases
ArachnoServeri | AS000290 M-ctenitoxin-Cs1b |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 4.7 pmol/mg on Drosophila.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000045039 | 1 – 35 | Cupiennin-1bAdd BLAST | 35 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | Glutamic acid 1-amide1 Publication | 1 |
Keywords - PTMi
AmidationExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
ProteinModelPortali | P83620 |
SMRi | P83620 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR035164 Cupiennin |
Pfami | View protein in Pfam PF17563 Cu, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P83620 |
SMRi | P83620 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ArachnoServeri | AS000290 M-ctenitoxin-Cs1b |
Family and domain databases
InterProi | View protein in InterPro IPR035164 Cupiennin |
Pfami | View protein in Pfam PF17563 Cu, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TXC1B_CUPSA | |
Accessioni | P83620Primary (citable) accession number: P83620 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | September 19, 2003 | |
Last modified: | June 20, 2018 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families