UniProtKB - P83508 (AVP2_CAVPO)
Protein
Lipocalin Cav p 2.0101
Gene
Lcncavp2
Organism
Cavia porcellus (Guinea pig)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Lipocalin Cav p 2.01011 PublicationAlternative name(s): Major allergen Cav p 21 Publication Allergen: Cav p 2.01011 Publication |
Gene namesi | Name:Lcncavp2Imported |
Organismi | Cavia porcellus (Guinea pig)Curated |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE (PubMed:21518038, PubMed:12823123). Binds to IgE in 65% of the 26 patients tested allergic to guinea pigs (PubMed:21518038). Is a cause of guinea pig hair allergy (PubMed:12823123). Causes degranulation of humanized rat basophil leukemia cells (RBL) and release of beta-hexosaminidase (PubMed:21518038).2 Publications
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3183, Cav p 2.0101 618, Cav p 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | 2 PublicationsAdd BLAST | 16 | |
ChainiPRO_0000201031 | 17 – 170 | Lipocalin Cav p 2.01012 PublicationsAdd BLAST | 154 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 60 | By similarity | ||
Disulfide bondi | 75 ↔ 168 | By similarity |
Post-translational modificationi
Not N-linked glycosylated.1 Publication
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
GeneTreei | ENSGT00960000186645 |
OrthoDBi | 1357921at2759 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002448, OBP-like |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01173, ODORANTBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P83508-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQILLLALA VSLACADSID YSKVPGNWRT IAIAADHVEK IEVNGELRAY
60 70 80 90 100
FRQVDCTEGC DKISITFYTN TDGVCTEHTV VGARNGENDV YTVDYAGENT
110 120 130 140 150
FQILCNSDDA FVIGSVNTDQ NGQTTKEVAI AAKRNFLTPE QEQKFQKAVQ
160 170
NAGIPLENIR YVIETDTCPD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN256284 mRNA Translation: CAX62129.1 AAKN02052698 Genomic DNA No translation available. |
RefSeqi | NP_001192113.1, NM_001205184.1 |
Genome annotation databases
Ensembli | ENSCPOT00000035307; ENSCPOP00000025189; ENSCPOG00000037628 |
GeneIDi | 100534654 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FN256284 mRNA Translation: CAX62129.1 AAKN02052698 Genomic DNA No translation available. |
RefSeqi | NP_001192113.1, NM_001205184.1 |
3D structure databases
SMRi | P83508 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 3183, Cav p 2.0101 618, Cav p 2 |
Genome annotation databases
Ensembli | ENSCPOT00000035307; ENSCPOP00000025189; ENSCPOG00000037628 |
GeneIDi | 100534654 |
Organism-specific databases
CTDi | 100534654 |
Phylogenomic databases
GeneTreei | ENSGT00960000186645 |
OrthoDBi | 1357921at2759 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002448, OBP-like |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01173, ODORANTBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AVP2_CAVPO | |
Accessioni | P83508Primary (citable) accession number: P83508 Secondary accession number(s): F0UZ11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2003 |
Last sequence update: | July 3, 2019 | |
Last modified: | February 26, 2020 | |
This is version 46 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Allergens
Nomenclature of allergens and list of entries - SIMILARITY comments
Index of protein domains and families