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Protein

Nyctalopin

Gene

Nyx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • response to stimulus Source: UniProtKB-KW
  • visual perception Source: MGI

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Nyctalopin
Gene namesi
Name:Nyx
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448607 Nyx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Nyx are the cause of the nob (no b-wave) phenotype which is characterized by a decreased sensitivity to light and an absence of the rod b-wave in electroretinograms. An 85-bp deletion in exon 3 results in the loss of 288 residues from the C-terminus of the protein.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003277719 – 476NyctalopinAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP83503
PRIDEiP83503

PTM databases

iPTMnetiP83503
PhosphoSitePlusiP83503

Expressioni

Tissue specificityi

Expressed abundantly in retina with lower levels in brain, lung, spleen and testis. Not detected in kidney, heart or liver. In the retina, highest expression found in the inner nuclear layer and ganglion cell layer.2 Publications

Developmental stagei

Expressed during all stages of postnatal retinal development.1 Publication

Gene expression databases

BgeeiENSMUSG00000051228 Expressed in 36 organ(s), highest expression level in embryo
CleanExiMM_NYX
GenevisibleiP83503 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056313

Structurei

3D structure databases

ProteinModelPortaliP83503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 57LRRNTAdd BLAST39
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 128LRR 3Add BLAST23
Repeati131 – 154LRR 4Add BLAST24
Repeati155 – 177LRR 5Add BLAST23
Repeati178 – 199LRR 6Add BLAST22
Repeati202 – 223LRR 7Add BLAST22
Repeati226 – 247LRR 8Add BLAST22
Repeati250 – 271LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Domaini331 – 383LRRCTAdd BLAST53

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150867
HOGENOMiHOG000230477
HOVERGENiHBG031762
InParanoidiP83503
KOiK08129
OMAiFRNPWEC
OrthoDBiEOG091G05RT
PhylomeDBiP83503
TreeFamiTF337463

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83503-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLILLLHAVV FSLPYTRATE ACLRACPAAC TCSHVERGCS VRCDRAGLQR
60 70 80 90 100
VPQEFPCEAA SIDLDRNGLR ILGERAFGTL PSLRRLSLRH NNLSFITPGA
110 120 130 140 150
FKGLPRLAEL RLAHNGELRY LHVRTFAALG RLRRLDLAAC RLFSVPERLL
160 170 180 190 200
AELPALRELT AFDNLFRRVP GALRGLANLT HAHFERSRIE AVASGSLLGM
210 220 230 240 250
RRLRSLSLQA NRVRAVHAGA FGDCGALEDL LLNDNLLATL PAAAFRGLRR
260 270 280 290 300
LRTLNLGGNA LGSVARAWFS DLAELELLYL DRNSITFVEE GAFQNLSGLL
310 320 330 340 350
ALHLNGNRLT VLSWAAFQPG FFLGRLFLFR NPWRCDCQLE WLRDWMEGSG
360 370 380 390 400
RVADVACASP GSVAGQDLSQ VVFERSSDGL CVDPDELNFT TSSPGPSPEP
410 420 430 440 450
VATTVSRFSS LLSKLLAPRA PVEEVANTTW ELVNVSLNDS FRSHAVMVFC
460 470
YKATFLFTSC VLLSLAQYVV VGLQRE
Length:476
Mass (Da):52,431
Last modified:March 1, 2003 - v1
Checksum:iAF575C25638BC410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114303 mRNA Translation: AAM47034.1
BC035244 mRNA Translation: AAH35244.1
BC048381 mRNA Translation: AAH48381.1
AK038912 mRNA Translation: BAC30165.1
CCDSiCCDS40877.1
RefSeqiNP_775591.1, NM_173415.4
XP_006527675.1, XM_006527612.3
XP_006527676.1, XM_006527613.3
XP_006527677.1, XM_006527614.3
UniGeneiMm.90233

Genome annotation databases

EnsembliENSMUST00000050434; ENSMUSP00000056313; ENSMUSG00000051228
GeneIDi236690
KEGGimmu:236690
UCSCiuc009srn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114303 mRNA Translation: AAM47034.1
BC035244 mRNA Translation: AAH35244.1
BC048381 mRNA Translation: AAH48381.1
AK038912 mRNA Translation: BAC30165.1
CCDSiCCDS40877.1
RefSeqiNP_775591.1, NM_173415.4
XP_006527675.1, XM_006527612.3
XP_006527676.1, XM_006527613.3
XP_006527677.1, XM_006527614.3
UniGeneiMm.90233

3D structure databases

ProteinModelPortaliP83503
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056313

PTM databases

iPTMnetiP83503
PhosphoSitePlusiP83503

Proteomic databases

PaxDbiP83503
PRIDEiP83503

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050434; ENSMUSP00000056313; ENSMUSG00000051228
GeneIDi236690
KEGGimmu:236690
UCSCiuc009srn.1 mouse

Organism-specific databases

CTDi60506
MGIiMGI:2448607 Nyx

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150867
HOGENOMiHOG000230477
HOVERGENiHBG031762
InParanoidiP83503
KOiK08129
OMAiFRNPWEC
OrthoDBiEOG091G05RT
PhylomeDBiP83503
TreeFamiTF337463

Miscellaneous databases

PROiPR:P83503
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051228 Expressed in 36 organ(s), highest expression level in embryo
CleanExiMM_NYX
GenevisibleiP83503 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNYX_MOUSE
AccessioniPrimary (citable) accession number: P83503
Secondary accession number(s): Q8BYN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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