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Entry version 147 (17 Jun 2020)
Sequence version 1 (30 Aug 2002)
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Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name:
COG complex subunit 7
Alternative name(s):
Component of oligomeric Golgi complex 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG7
ORF Names:UNQ3082/PRO10013
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168434.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18622 COG7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606978 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P83436

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2E (CDG2E)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Related information in OMIM

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNET

More...
DisGeNETi
91949

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
COG7

MalaCards human disease database

More...
MalaCardsi
COG7
MIMi608779 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168434

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79333 COG7-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P83436 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105843

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COG7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22653684

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135181 – 770Conserved oligomeric Golgi complex subunit 7Add BLAST770

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P83436

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P83436

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P83436

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P83436

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P83436

PeptideAtlas

More...
PeptideAtlasi
P83436

PRoteomics IDEntifications database

More...
PRIDEi
P83436

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57736

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P83436

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P83436

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168434 Expressed in adenohypophysis and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P83436 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P83436 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168434 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124896, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P83436

Protein interaction database and analysis system

More...
IntActi
P83436, 25 interactors

Molecular INTeraction database

More...
MINTi
P83436

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305442

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P83436 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P83436

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG7 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4182 Eukaryota
ENOG410XT6U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001260

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006044_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P83436

KEGG Orthology (KO)

More...
KOi
K20294

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFEYFHK

Database of Orthologous Groups

More...
OrthoDBi
280917at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P83436

TreeFam database of animal gene trees

More...
TreeFami
TF324498

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019335 COG7

The PANTHER Classification System

More...
PANTHERi
PTHR21443 PTHR21443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10191 COG7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P83436-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE
60 70 80 90 100
VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD
110 120 130 140 150
TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI
160 170 180 190 200
SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA
210 220 230 240 250
VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL
260 270 280 290 300
TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN
310 320 330 340 350
GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA
360 370 380 390 400
VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG
410 420 430 440 450
LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD
460 470 480 490 500
HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY
510 520 530 540 550
LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL
560 570 580 590 600
YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM
610 620 630 640 650
DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS
660 670 680 690 700
ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI
710 720 730 740 750
PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV
760 770
SKGLPRRLAT TVATMRSVNY
Length:770
Mass (Da):86,344
Last modified:August 30, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14DAC431B291582C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L337I3L337_HUMAN
Conserved oligomeric Golgi complex ...
COG7
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2R8I3L2R8_HUMAN
Conserved oligomeric Golgi complex ...
COG7
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88995 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048762605T → M. Corresponds to variant dbSNP:rs16940094EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC000549 mRNA Translation: AAH00549.1
BC037563 mRNA Translation: AAH37563.1
AY358632 mRNA Translation: AAQ88995.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10610.1

NCBI Reference Sequences

More...
RefSeqi
NP_705831.1, NM_153603.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307149; ENSP00000305442; ENSG00000168434

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91949

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91949

UCSC genome browser

More...
UCSCi
uc002dlo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000549 mRNA Translation: AAH00549.1
BC037563 mRNA Translation: AAH37563.1
AY358632 mRNA Translation: AAQ88995.1 Different initiation.
CCDSiCCDS10610.1
RefSeqiNP_705831.1, NM_153603.3

3D structure databases

SMRiP83436
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124896, 52 interactors
CORUMiP83436
IntActiP83436, 25 interactors
MINTiP83436
STRINGi9606.ENSP00000305442

Chemistry databases

ChEMBLiCHEMBL4105843

PTM databases

iPTMnetiP83436
PhosphoSitePlusiP83436

Polymorphism and mutation databases

BioMutaiCOG7
DMDMi22653684

Proteomic databases

EPDiP83436
jPOSTiP83436
MassIVEiP83436
MaxQBiP83436
PaxDbiP83436
PeptideAtlasiP83436
PRIDEiP83436
ProteomicsDBi57736

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25940 191 antibodies

Genome annotation databases

EnsembliENST00000307149; ENSP00000305442; ENSG00000168434
GeneIDi91949
KEGGihsa:91949
UCSCiuc002dlo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91949
DisGeNETi91949
EuPathDBiHostDB:ENSG00000168434.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COG7
GeneReviewsiCOG7
HGNCiHGNC:18622 COG7
HPAiENSG00000168434 Low tissue specificity
MalaCardsiCOG7
MIMi606978 gene
608779 phenotype
neXtProtiNX_P83436
OpenTargetsiENSG00000168434
Orphaneti79333 COG7-CDG
PharmGKBiPA38605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4182 Eukaryota
ENOG410XT6U LUCA
GeneTreeiENSGT00390000001260
HOGENOMiCLU_006044_2_0_1
InParanoidiP83436
KOiK20294
OMAiIFEYFHK
OrthoDBi280917at2759
PhylomeDBiP83436
TreeFamiTF324498

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
91949 148 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COG7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COG7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
91949
PharosiP83436 Tbio

Protein Ontology

More...
PROi
PR:P83436
RNActiP83436 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168434 Expressed in adenohypophysis and 208 other tissues
ExpressionAtlasiP83436 baseline and differential
GenevisibleiP83436 HS

Family and domain databases

InterProiView protein in InterPro
IPR019335 COG7
PANTHERiPTHR21443 PTHR21443, 1 hit
PfamiView protein in Pfam
PF10191 COG7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83436
Secondary accession number(s): Q6UWU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 17, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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