Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U7 snRNA-associated Sm-like protein LSm11

Gene

LSM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.By similarity1 Publication

GO - Molecular functioni

  • U7 snRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm11
Gene namesi
Name:LSM11
OrganismiHomo sapiens (Human)Curated
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000155858.5
HGNCiHGNC:30860 LSM11
MIMi617910 gene
neXtProtiNX_P83369

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155858
PharmGKBiPA134983181

Polymorphism and mutation databases

BioMutaiLSM11
DMDMi47117879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255871 – 360U7 snRNA-associated Sm-like protein LSm11Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei41Omega-N-methylarginineBy similarity1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei154PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1

Post-translational modificationi

Not methylated.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP83369
MaxQBiP83369
PaxDbiP83369
PeptideAtlasiP83369
PRIDEiP83369
ProteomicsDBi57735

PTM databases

iPTMnetiP83369
PhosphoSitePlusiP83369

Expressioni

Gene expression databases

BgeeiENSG00000155858 Expressed in 189 organ(s), highest expression level in brain
CleanExiHS_LSM11
GenevisibleiP83369 HS

Organism-specific databases

HPAiHPA039587

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with LSM10, SMN, SNRPB and ZNF473. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts (via the Sm domains) with CLNS1A. Interacts with PRMT5 and WDR77 (By similarity).By similarity

Protein-protein interaction databases

BioGridi126394, 34 interactors
CORUMiP83369
IntActiP83369, 20 interactors
STRINGi9606.ENSP00000286307

Structurei

3D structure databases

ProteinModelPortaliP83369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 204SM 1Add BLAST34
Regioni343 – 356SM 2Add BLAST14

Domaini

The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (By similarity). The N-terminal domain is essential for histone pre-mRNA cleavage. Amino acids 63-82 are sufficient to interact with ZNF473.By similarity

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IRD3 Eukaryota
ENOG4111F1R LUCA
GeneTreeiENSGT00390000012944
HOGENOMiHOG000035131
HOVERGENiHBG052367
InParanoidiP83369
OMAiSVWGRAD
OrthoDBiEOG091G0PNU
PhylomeDBiP83369
TreeFamiTF326954

Family and domain databases

CDDicd01739 LSm11_M, 1 hit
InterProiView protein in InterPro
IPR039267 Lsm11
IPR034109 Lsm11_M
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR21415 PTHR21415, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 2 hits

Sequencei

Sequence statusi: Complete.

P83369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEERERGARS AGAGSPARPP SPRLDVSSDS FDPLLALYAP RLPPIPYPNA
60 70 80 90 100
PCFNNVAEYE SFLRTGVRGG GRGRGRARGA AAGSGVPAAP GPSGRTRRRP
110 120 130 140 150
DAPAPDPERI QRLRRLMVAK EEGDGAAGAG RRGPGRSRKA PRNVLTRMPL
160 170 180 190 200
HEGSPLGELH RCIREGVKVN VHIRTFKGLR GVCTGFLVAF DKFWNMALTD
210 220 230 240 250
VDETYRKPVL GKAYERDSSL TLTRLFDRLK LQDSSKKEAD SKSAVEDSTL
260 270 280 290 300
SRYSQTSTWK LASVWGRADT GRGSHKRSRS VPSSLQASAR EESRSELSGR
310 320 330 340 350
TTRTDGSSVG GTFSRATTLS RGQSRKKKRK PKVDYQQVFT RHINQIFIRG
360
ENVLLVHLAQ
Length:360
Mass (Da):39,500
Last modified:May 10, 2004 - v2
Checksum:i3C97710C28C0DCE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095592 mRNA Translation: BAC04581.1
BC051353 mRNA Translation: AAH51353.1
BC126449 mRNA Translation: AAI26450.1
CCDSiCCDS4342.1
RefSeqiNP_775762.1, NM_173491.3
UniGeneiHs.23648
Hs.631954

Genome annotation databases

EnsembliENST00000286307; ENSP00000286307; ENSG00000155858
GeneIDi134353
KEGGihsa:134353
UCSCiuc003lxf.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095592 mRNA Translation: BAC04581.1
BC051353 mRNA Translation: AAH51353.1
BC126449 mRNA Translation: AAI26450.1
CCDSiCCDS4342.1
RefSeqiNP_775762.1, NM_173491.3
UniGeneiHs.23648
Hs.631954

3D structure databases

ProteinModelPortaliP83369
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126394, 34 interactors
CORUMiP83369
IntActiP83369, 20 interactors
STRINGi9606.ENSP00000286307

PTM databases

iPTMnetiP83369
PhosphoSitePlusiP83369

Polymorphism and mutation databases

BioMutaiLSM11
DMDMi47117879

Proteomic databases

EPDiP83369
MaxQBiP83369
PaxDbiP83369
PeptideAtlasiP83369
PRIDEiP83369
ProteomicsDBi57735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286307; ENSP00000286307; ENSG00000155858
GeneIDi134353
KEGGihsa:134353
UCSCiuc003lxf.2 human

Organism-specific databases

CTDi134353
EuPathDBiHostDB:ENSG00000155858.5
GeneCardsiLSM11
HGNCiHGNC:30860 LSM11
HPAiHPA039587
MIMi617910 gene
neXtProtiNX_P83369
OpenTargetsiENSG00000155858
PharmGKBiPA134983181
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRD3 Eukaryota
ENOG4111F1R LUCA
GeneTreeiENSGT00390000012944
HOGENOMiHOG000035131
HOVERGENiHBG052367
InParanoidiP83369
OMAiSVWGRAD
OrthoDBiEOG091G0PNU
PhylomeDBiP83369
TreeFamiTF326954

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

GenomeRNAii134353
PROiPR:P83369
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155858 Expressed in 189 organ(s), highest expression level in brain
CleanExiHS_LSM11
GenevisibleiP83369 HS

Family and domain databases

CDDicd01739 LSm11_M, 1 hit
InterProiView protein in InterPro
IPR039267 Lsm11
IPR034109 Lsm11_M
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PANTHERiPTHR21415 PTHR21415, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLSM11_HUMAN
AccessioniPrimary (citable) accession number: P83369
Secondary accession number(s): A0AVQ1, Q7Z7P0, Q8N975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again