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Protein

Hemoglobin subunit beta-2

Gene

hbb2

Organism
Anarhichas minor (Arctic spotted wolffish)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.1 Publication

Miscellaneous

Hb3 displays pronounced Bohr and root effects, accompanied by strong organophosphate regulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi92Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-2
Alternative name(s):
Beta-2-globin
Hemoglobin beta-2 chain
Gene namesi
Name:hbb2
OrganismiAnarhichas minor (Arctic spotted wolffish)
Taxonomic identifieri65739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesAnarhichadidaeAnarhichas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528671 – 146Hemoglobin subunit beta-2Add BLAST146

Expressioni

Tissue specificityi

Red blood cells.1 Publication

Interactioni

Subunit structurei

Hb3 is a heterotetramer of two alpha-2 chains and two beta-2 chains.

Structurei

3D structure databases

ProteinModelPortaliP83273
SMRiP83273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P83273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VEWTDFERAT IQDIFSKMDY EVVGPAALSR CLIVYPWTQR YFGSFGNLYN
60 70 80 90 100
AAAIMGNPNV AKHGTIILHG LDRGVKNMDN IKETYAELSV LHSEKLHVDP
110 120 130 140
DNFKLISDCL TVVVAAQFGK AFTGEVQAAF QKFMAVVVSA LGRQYH
Length:146
Mass (Da):16,289
Last modified:August 2, 2002 - v1
Checksum:i139B6730B659B800
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP83273
SMRiP83273
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBB2_ANAMI
AccessioniPrimary (citable) accession number: P83273
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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