Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-amaurobitoxin-Pl1a

Gene
N/A
Organism
Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels. This toxin is active only on insects. Has a potent activity against S.litura larvae.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei8PharmacophoreBy similarity1
Sitei12PharmacophoreBy similarity1
Sitei22PharmacophoreBy similarity1
Sitei24PharmacophoreBy similarity1
Sitei26PharmacophoreBy similarity1
Sitei28PharmacophoreBy similarity1
Sitei30PharmacophoreBy similarity1
Sitei32PharmacophoreBy similarity1
Sitei34PharmacophoreBy similarity1

GO - Molecular functioni

  • sodium channel inhibitor activity Source: UniProtKB
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-amaurobitoxin-Pl1a
Short name:
Delta-AMATX-Pl1a
Alternative name(s):
Delta-palutoxin IT11 Publication
Short name:
Delta-paluIT11 Publication
OrganismiPireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus)
Taxonomic identifieri185217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAmaurobiidaePireneitega

Organism-specific databases

ArachnoServeriAS000301 delta-Amaurobitoxin-Pl1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449611 – 37Delta-amaurobitoxin-Pl1aAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 182 Publications
Disulfide bondi9 ↔ 232 Publications
Disulfide bondi17 ↔ 332 Publications
Disulfide bondi25 ↔ 312 Publications
Modified residuei37Serine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Turni11 – 13Combined sources3
Beta strandi26 – 29Combined sources4

3D structure databases

ProteinModelPortaliP83256
SMRiP83256
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83256

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR016328 Beta/delta-agatoxin_fam
PIRSFiPIRSF001882 Curtatoxin, 1 hit
PROSITEiView protein in PROSITE
PS60015 MU_AGATOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P83256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GCLGEGEKCA DWSGPSCCDG FYCSCRSMPY CRCRNNS
Length:37
Mass (Da):4,047
Last modified:March 1, 2002 - v1
Checksum:iE019DABCC25BC11E
GO

Mass spectrometryi

Molecular mass is 4037.9 Da from positions 1 - 37. Determined by MALDI. 1 Publication

Sequence databases

PIRiA59401

Similar proteinsi

Entry informationi

Entry nameiT3D1A_PIRLC
AccessioniPrimary (citable) accession number: P83256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health