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UniProtKB - P83189 (PS2_PSEPD)
Protein
Pseudin-2
Gene
N/A
Organism
Pseudis paradoxa (Paradoxical frog)
Status
Functioni
Antimicrobial peptide with activity against fungus (C.albicans) and Gram-positive and Gram-negative bacteria (S.aureus and E.coli) (PubMed:11689009).
Also has low hemolytic activity against human erythrocytes (PubMed:11689009).
1 PublicationGO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
- defense response to fungus Source: UniProtKB
- hemolysis in another organism Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- xenobiotic metabolic process Source: UniProtKB
Keywordsi
Molecular function | Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide |
Biological process | Cytolysis, Hemolysis, Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Pseudin-21 Publication |
Organismi | Pseudis paradoxa (Paradoxical frog) |
Taxonomic identifieri | 43558 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Hyloidea › Hylidae › Hylinae › Dendropsophini › Pseudis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000043829 | 1 – 24 | Pseudin-21 PublicationAdd BLAST | 24 |
Expressioni
Tissue specificityi
Expressed by the skin glands.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P83189 |
BMRBi | P83189 |
SMRi | P83189 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR013156, Antimicrobial_19 |
Pfami | View protein in Pfam PF08225, Antimicrobial19, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 2685.4 Da. Determined by ESI. 1 Publication
Similar proteinsi
Cross-referencesi
Web resourcesi
The antimicrobial peptide database |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NCX | NMR | - | A | 1-24 | [»] | |
2NCY | NMR | - | A | 1-24 | [»] | |
AlphaFoldDBi | P83189 | |||||
BMRBi | P83189 | |||||
SMRi | P83189 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR013156, Antimicrobial_19 |
Pfami | View protein in Pfam PF08225, Antimicrobial19, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PS2_PSEPD | |
Accessioni | P83189Primary (citable) accession number: P83189 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families