UniProtKB - P83180 (HCYB_ASTLP)
Protein
Hemocyanin B chain
Gene
N/A
Organism
Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)
Status
Functioni
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.Curated
Miscellaneous
The B chain contains two copper-binding sites. Three histidine residues are ligands to each copper ion.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 183 | Copper ABy similarity | 1 | |
Metal bindingi | 187 | Copper ABy similarity | 1 | |
Metal bindingi | 213 | Copper ABy similarity | 1 | |
Metal bindingi | 309 | Copper BBy similarity | 1 | |
Metal bindingi | 313 | Copper BBy similarity | 1 | |
Metal bindingi | 347 | Copper BBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemocyanin B chain |
Organismi | Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)Curated |
Taxonomic identifieri | 6717 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Crustacea › Multicrustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Pleocyemata › Astacidea › Astacoidea › Astacidae › Astacus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204298 | 1 – 566 | Hemocyanin B chainAdd BLAST | 566 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 82 ↔ 87 | By similarity |
Keywords - PTMi
Disulfide bondPTM databases
GlyConnecti | 212, 6 N-Linked glycans |
Expressioni
Tissue specificityi
Hemolymph.
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.1280.10, 1 hit 1.20.1370.10, 1 hit 2.60.40.1520, 1 hit |
InterProi | View protein in InterPro IPR013788, Hemocyanin/hexamerin IPR000896, Hemocyanin/hexamerin_mid_dom IPR005203, Hemocyanin_C IPR037020, Hemocyanin_C_sf IPR005204, Hemocyanin_N IPR036697, Hemocyanin_N_sf IPR014756, Ig_E-set IPR002227, Tyrosinase_Cu-bd IPR008922, Unchr_di-copper_centre |
PANTHERi | PTHR11511, PTHR11511, 1 hit |
Pfami | View protein in Pfam PF03723, Hemocyanin_C, 1 hit PF00372, Hemocyanin_M, 1 hit PF03722, Hemocyanin_N, 1 hit |
PRINTSi | PR00187, HAEMOCYANIN |
SUPFAMi | SSF48050, SSF48050, 1 hit SSF48056, SSF48056, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00209, HEMOCYANIN_1, 1 hit PS00210, HEMOCYANIN_2, 1 hit PS00498, TYROSINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P83180-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DASGATLAKR QQVVNHLLEH IYDHTHFTDL KNIAGTFSPE AATSIYTDDM
60 70 80 90 100
EELRDGRLLE QHHWFSLFNT RQRMLFEVLI HCKSWECFLD NAAYFRERMN
110 120 130 140 150
EGEFVYAIYV AVIHSGIGHG IVIPPIYEVT PHIFTNSEVI NKAYSAKMTQ
160 170 180 190 200
TPGRFNMDFT GTKKNKEQRV AYFGEDIGMN IHHVTWHMDF PFWWKDSYGY
210 220 230 240 250
HLDRKGELFF WVHHQLTARF DSERISNWID VVDEIHWSCI EGFAPHTSYK
260 270 280 290 300
YGGEFPARPD NVHFEDVDGV ARVRDSRIRD ALAHGYLLDN SGNKSSVYSP
310 320 330 340 350
NVQYYGAIHN TAHIMIGRQG DHKFDMPPGV MEHFETATRD PSFFRLHKYM
360 370 380 390 400
DNIFKEHKDS LPPYTKNDIA VPGVVIDSVA QLKTFFDTFE VNLGNAKVAD
410 420 430 440 450
VAISADVHRI NHEEFSYNID ISNTDKIFIC PVKDDNGIMD KFYKSIDPGT
460 470 480 490 500
NHIVRKSVDS SVTVPDRQYA LDLHMFERSC GIPNRDMIII ESRPDGMDFA
510 520 530 540 550
LFVTVDDPEE IGATHSQHGI KKYPDKKPMG YPVDRSIPDN RVFLESPNIK
560
RTYVKVFHDE HGGEQH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence uncertaintyi | 45 | I or L | 1 | |
Sequence uncertaintyi | 50 | Curated | 1 | |
Sequence uncertaintyi | 74 | Curated | 1 | |
Sequence uncertaintyi | 108 | I or L | 1 | |
Sequence uncertaintyi | 113 | I or L | 1 | |
Sequence uncertaintyi | 117 | I or L | 1 | |
Sequence uncertaintyi | 121 | I or L | 1 | |
Sequence uncertaintyi | 123 | I or L | 1 | |
Sequence uncertaintyi | 126 | I or L | 1 | |
Sequence uncertaintyi | 133 | I or L | 1 | |
Sequence uncertaintyi | 140 | I or L | 1 | |
Sequence uncertaintyi | 225 | I or L | 1 | |
Sequence uncertaintyi | 229 | I or L | 1 | |
Sequence uncertaintyi | 235 | I or L | 1 | |
Sequence uncertaintyi | 308 | I or L | 1 | |
Sequence uncertaintyi | 314 | I or L | 1 | |
Sequence uncertaintyi | 316 | I or L | 1 | |
Sequence uncertaintyi | 369 | I or L | 1 | |
Sequence uncertaintyi | 376 | I or L | 1 | |
Sequence uncertaintyi | 410 | I or L | 1 | |
Sequence uncertaintyi | 419 | I or L | 1 | |
Sequence uncertaintyi | 421 | I or L | 1 | |
Sequence uncertaintyi | 427 | I or L | 1 | |
Sequence uncertaintyi | 429 | I or L | 1 | |
Sequence uncertaintyi | 446 | I or L | 1 | |
Sequence uncertaintyi | 453 | I or L | 1 | |
Sequence uncertaintyi | 488 | I or L | 1 | |
Sequence uncertaintyi | 489 | I or L | 1 | |
Sequence uncertaintyi | 490 | I or L | 1 | |
Sequence uncertaintyi | 511 | I or L | 1 | |
Sequence uncertaintyi | 518 | Curated | 1 | |
Sequence uncertaintyi | 520 | I or L | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 42 | A → DCurated | 1 | |
Natural varianti | 146 | A → GCurated | 1 | |
Natural varianti | 235 | I → GCurated | 1 | |
Natural varianti | 447 | D → ACurated | 1 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
GlyConnecti | 212, 6 N-Linked glycans |
Family and domain databases
Gene3Di | 1.10.1280.10, 1 hit 1.20.1370.10, 1 hit 2.60.40.1520, 1 hit |
InterProi | View protein in InterPro IPR013788, Hemocyanin/hexamerin IPR000896, Hemocyanin/hexamerin_mid_dom IPR005203, Hemocyanin_C IPR037020, Hemocyanin_C_sf IPR005204, Hemocyanin_N IPR036697, Hemocyanin_N_sf IPR014756, Ig_E-set IPR002227, Tyrosinase_Cu-bd IPR008922, Unchr_di-copper_centre |
PANTHERi | PTHR11511, PTHR11511, 1 hit |
Pfami | View protein in Pfam PF03723, Hemocyanin_C, 1 hit PF00372, Hemocyanin_M, 1 hit PF03722, Hemocyanin_N, 1 hit |
PRINTSi | PR00187, HAEMOCYANIN |
SUPFAMi | SSF48050, SSF48050, 1 hit SSF48056, SSF48056, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00209, HEMOCYANIN_1, 1 hit PS00210, HEMOCYANIN_2, 1 hit PS00498, TYROSINASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HCYB_ASTLP | |
Accessioni | P83180Primary (citable) accession number: P83180 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families