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Entry version 67 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Hemocyanin B chain

Gene
N/A
Organism
Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.Curated

Miscellaneous

The B chain contains two copper-binding sites. Three histidine residues are ligands to each copper ion.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi183Copper ABy similarity1
Metal bindingi187Copper ABy similarity1
Metal bindingi213Copper ABy similarity1
Metal bindingi309Copper BBy similarity1
Metal bindingi313Copper BBy similarity1
Metal bindingi347Copper BBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemocyanin B chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAstacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6717 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaeAstacus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042981 – 566Hemocyanin B chainAdd BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi82 ↔ 87By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P83180

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
212

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P83180

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hemolymph.

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tyrosinase family. Hemocyanin subfamily.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 1 hit
1.20.1370.10, 1 hit
2.60.40.1520, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013788 Hemocyanin/hexamerin
IPR000896 Hemocyanin/hexamerin_mid_dom
IPR005203 Hemocyanin_C
IPR037020 Hemocyanin_C_sf
IPR005204 Hemocyanin_N
IPR036697 Hemocyanin_N_sf
IPR014756 Ig_E-set
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre

The PANTHER Classification System

More...
PANTHERi
PTHR11511 PTHR11511, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03723 Hemocyanin_C, 1 hit
PF00372 Hemocyanin_M, 1 hit
PF03722 Hemocyanin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00187 HAEMOCYANIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48050 SSF48050, 1 hit
SSF48056 SSF48056, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00209 HEMOCYANIN_1, 1 hit
PS00210 HEMOCYANIN_2, 1 hit
PS00498 TYROSINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P83180-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DASGATLAKR QQVVNHLLEH IYDHTHFTDL KNIAGTFSPE AATSIYTDDM
60 70 80 90 100
EELRDGRLLE QHHWFSLFNT RQRMLFEVLI HCKSWECFLD NAAYFRERMN
110 120 130 140 150
EGEFVYAIYV AVIHSGIGHG IVIPPIYEVT PHIFTNSEVI NKAYSAKMTQ
160 170 180 190 200
TPGRFNMDFT GTKKNKEQRV AYFGEDIGMN IHHVTWHMDF PFWWKDSYGY
210 220 230 240 250
HLDRKGELFF WVHHQLTARF DSERISNWID VVDEIHWSCI EGFAPHTSYK
260 270 280 290 300
YGGEFPARPD NVHFEDVDGV ARVRDSRIRD ALAHGYLLDN SGNKSSVYSP
310 320 330 340 350
NVQYYGAIHN TAHIMIGRQG DHKFDMPPGV MEHFETATRD PSFFRLHKYM
360 370 380 390 400
DNIFKEHKDS LPPYTKNDIA VPGVVIDSVA QLKTFFDTFE VNLGNAKVAD
410 420 430 440 450
VAISADVHRI NHEEFSYNID ISNTDKIFIC PVKDDNGIMD KFYKSIDPGT
460 470 480 490 500
NHIVRKSVDS SVTVPDRQYA LDLHMFERSC GIPNRDMIII ESRPDGMDFA
510 520 530 540 550
LFVTVDDPEE IGATHSQHGI KKYPDKKPMG YPVDRSIPDN RVFLESPNIK
560
RTYVKVFHDE HGGEQH
Length:566
Mass (Da):65,289
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3DF4FDE3B87DFBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequences’ section is used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.<p><a href='/help/unsure' target='_top'>More...</a></p>Sequence uncertaintyi45I or L1
Sequence uncertaintyi50Curated1
Sequence uncertaintyi74Curated1
Sequence uncertaintyi108I or L1
Sequence uncertaintyi113I or L1
Sequence uncertaintyi117I or L1
Sequence uncertaintyi121I or L1
Sequence uncertaintyi123I or L1
Sequence uncertaintyi126I or L1
Sequence uncertaintyi133I or L1
Sequence uncertaintyi140I or L1
Sequence uncertaintyi225I or L1
Sequence uncertaintyi229I or L1
Sequence uncertaintyi235I or L1
Sequence uncertaintyi308I or L1
Sequence uncertaintyi314I or L1
Sequence uncertaintyi316I or L1
Sequence uncertaintyi369I or L1
Sequence uncertaintyi376I or L1
Sequence uncertaintyi410I or L1
Sequence uncertaintyi419I or L1
Sequence uncertaintyi421I or L1
Sequence uncertaintyi427I or L1
Sequence uncertaintyi429I or L1
Sequence uncertaintyi446I or L1
Sequence uncertaintyi453I or L1
Sequence uncertaintyi488I or L1
Sequence uncertaintyi489I or L1
Sequence uncertaintyi490I or L1
Sequence uncertaintyi511I or L1
Sequence uncertaintyi518Curated1
Sequence uncertaintyi520I or L1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti42A → DCurated1
Natural varianti146A → GCurated1
Natural varianti235I → GCurated1
Natural varianti447D → ACurated1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

GlyConnecti212
UniCarbKBiP83180

Proteomic databases

PRIDEiP83180

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
1.20.1370.10, 1 hit
2.60.40.1520, 1 hit
InterProiView protein in InterPro
IPR013788 Hemocyanin/hexamerin
IPR000896 Hemocyanin/hexamerin_mid_dom
IPR005203 Hemocyanin_C
IPR037020 Hemocyanin_C_sf
IPR005204 Hemocyanin_N
IPR036697 Hemocyanin_N_sf
IPR014756 Ig_E-set
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PANTHERiPTHR11511 PTHR11511, 1 hit
PfamiView protein in Pfam
PF03723 Hemocyanin_C, 1 hit
PF00372 Hemocyanin_M, 1 hit
PF03722 Hemocyanin_N, 1 hit
PRINTSiPR00187 HAEMOCYANIN
SUPFAMiSSF48050 SSF48050, 1 hit
SSF48056 SSF48056, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00209 HEMOCYANIN_1, 1 hit
PS00210 HEMOCYANIN_2, 1 hit
PS00498 TYROSINASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCYB_ASTLP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83180
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: May 8, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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