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Entry version 99 (08 May 2019)
Sequence version 2 (14 Oct 2008)
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Protein

G-protein coupled receptor Mth

Gene

mth

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in biological aging and stress response. Essential for adult survival (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor Mth
Alternative name(s):
Protein methuselah
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mth
ORF Names:GD25710
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila simulans (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000304 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2R, Unassembled WGS sequence

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0043394 Dsim\mth

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 218ExtracellularSequence analysisAdd BLAST194
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 239Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini240 – 248CytoplasmicSequence analysis9
Transmembranei249 – 269Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini270 – 278ExtracellularSequence analysis9
Transmembranei279 – 299Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini300 – 320CytoplasmicSequence analysisAdd BLAST21
Transmembranei321 – 341Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini342 – 370ExtracellularSequence analysisAdd BLAST29
Transmembranei371 – 391Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini392 – 424CytoplasmicSequence analysisAdd BLAST33
Transmembranei425 – 445Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini446 – 454ExtracellularSequence analysis9
Transmembranei455 – 475Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini476 – 515CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24By similarityAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001302125 – 515G-protein coupled receptor MthAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 83By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi85 ↔ 90By similarity
Disulfide bondi94 ↔ 188By similarity
Disulfide bondi95 ↔ 106By similarity
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi150 ↔ 209By similarity
Glycosylationi170N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P83120

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0043394 Expressed in 4 organ(s), highest expression level in female reproductive system

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P83120

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04599

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFYNCWI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P83120

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00251 Mth_Ecto, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.180.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR023311 Methusela_ecto_dom_2
IPR010596 Methuselah_N_dom
IPR036272 Methuselah_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF06652 Methuselah_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63877 SSF63877, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P83120-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLFVLRIS TVILVVLVIQ KSYADILECD YFDTVDISAA QKLQNGSYLF
60 70 80 90 100
EGLLVPAILT GEYDFRILPD DSKQKVASHI RGCVCKLKPC VRFCCPHDHI
110 120 130 140 150
MDNGVCNDNM SEEELTELDP FLNVTLDDGS VSRRHFKNEL IVQWDLPMPC
160 170 180 190 200
DGMFYLDNRE EQDQYTLFEN GTFFRHFDRV TLSKREYCLQ HLTFADGNAT
210 220 230 240 250
SIRIAPHNCL IVPSITGQTV VMITSLICMV LTIAVYLFVK KLQNLHGKCF
260 270 280 290 300
ICYMVCLFMG YLFLLFDLWQ ISISFCKPAG VLGYFFVMAA FLWLSVISLH
310 320 330 340 350
LWNTFRGSSH KASRFFSEHR FLAYNTYAWG MSMVLTGITV LADNVVEDQD
360 370 380 390 400
WNPRVGEEGH CWIYTQAWSA MLYFYGPMVF LIAFNITMFI LTARRIIGVK
410 420 430 440 450
KDIQNFAHRQ ERKQKLNSDK QTYTFFLRLF IIMGLSWSLE IGSYISQSNQ
460 470 480 490 500
TWANVFLVAD YLNWSQGIII FILFILKRST LRLLQESIRG EGEEVDNSEE
510
EISLENTRFD RNVLS
Length:515
Mass (Da):59,601
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i234BD93FEF2BE32E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti15V → F in strain: GA2.1S, HFL2.1S and HFL4.1S. 1 Publication1
Natural varianti27L → P in strain: GA2.1S, HFL2.1S, HFL4.1S and VA8.1S. 1 Publication1
Natural varianti60T → A in strain: HFL2.1S, HFL4.1S and VA8.1S. 1 Publication1
Natural varianti277K → R in strain: CT2.1S, CT5.1S, CT6.1S and VA6.1S. 1 Publication1
Natural varianti345V → L in strain: GA2.1S. 1 Publication1
Natural varianti442G → A in strain: HFL2.1S, VA7.1S and VA8.1S. 1 Publication1
Natural varianti491E → V in strain: HFL4.1S. 1 Publication1
Natural varianti496D → N in strain: GA2.1S, GA4.1S, GA5.1S, HFL1.1S, HFL2.1S, HFL4.1S, VA7.1S and VA8.1S. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF280590 Genomic DNA Translation: AAK49857.1
AF280591 Genomic DNA Translation: AAK49858.1
AF280592 Genomic DNA Translation: AAK49859.1
AF280593 Genomic DNA Translation: AAK49860.1
AF280594 Genomic DNA Translation: AAK49861.1
AF280595 Genomic DNA Translation: AAK49862.1
AF280596 Genomic DNA Translation: AAK49863.1
AF280597 Genomic DNA Translation: AAK49864.1
AF280598 Genomic DNA Translation: AAK49865.1
AF280599 Genomic DNA Translation: AAK49866.1
AF280600 Genomic DNA Translation: AAK49867.1
AF280601 Genomic DNA Translation: AAK49868.1
AF280602 Genomic DNA Translation: AAK49869.1
CM000362 Genomic DNA Translation: EDX07023.1

NCBI Reference Sequences

More...
RefSeqi
XP_016029709.1, XM_016182032.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0225620; FBpp0224112; FBgn0043394

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6734418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dsi:Dsimw501_GD25710

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF280590 Genomic DNA Translation: AAK49857.1
AF280591 Genomic DNA Translation: AAK49858.1
AF280592 Genomic DNA Translation: AAK49859.1
AF280593 Genomic DNA Translation: AAK49860.1
AF280594 Genomic DNA Translation: AAK49861.1
AF280595 Genomic DNA Translation: AAK49862.1
AF280596 Genomic DNA Translation: AAK49863.1
AF280597 Genomic DNA Translation: AAK49864.1
AF280598 Genomic DNA Translation: AAK49865.1
AF280599 Genomic DNA Translation: AAK49866.1
AF280600 Genomic DNA Translation: AAK49867.1
AF280601 Genomic DNA Translation: AAK49868.1
AF280602 Genomic DNA Translation: AAK49869.1
CM000362 Genomic DNA Translation: EDX07023.1
RefSeqiXP_016029709.1, XM_016182032.1

3D structure databases

SMRiP83120
ModBaseiSearch...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

PRIDEiP83120

Genome annotation databases

EnsemblMetazoaiFBtr0225620; FBpp0224112; FBgn0043394
GeneIDi6734418
KEGGidsi:Dsimw501_GD25710

Organism-specific databases

FlyBaseiFBgn0043394 Dsim\mth

Phylogenomic databases

KOiK04599
OMAiGFYNCWI
PhylomeDBiP83120

Gene expression databases

BgeeiFBgn0043394 Expressed in 4 organ(s), highest expression level in female reproductive system

Family and domain databases

CDDicd00251 Mth_Ecto, 1 hit
Gene3Di2.170.180.11, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR023311 Methusela_ecto_dom_2
IPR010596 Methuselah_N_dom
IPR036272 Methuselah_N_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF06652 Methuselah_N, 1 hit
SUPFAMiSSF63877 SSF63877, 1 hit
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTH_DROSI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P83120
Secondary accession number(s): B4QEZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 14, 2008
Last modified: May 8, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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