UniProtKB - P83105 (HTRA4_HUMAN)
Protein
Serine protease HTRA4
Gene
HTRA4
Organism
Homo sapiens (Human)
Status
Functioni
Serine protease.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 218 | Charge relay systemSequence analysis | 1 | |
Active sitei | 248 | Charge relay systemSequence analysis | 1 | |
Active sitei | 326 | Charge relay systemSequence analysis | 1 |
GO - Molecular functioni
- endopeptidase activity Source: BHF-UCL
- identical protein binding Source: IntAct
- insulin-like growth factor binding Source: InterPro
- serine-type endopeptidase activity Source: InterPro
GO - Biological processi
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- proteolysis Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
PathwayCommonsi | P83105 |
Protein family/group databases
MEROPSi | S01.285 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine protease HTRA4 (EC:3.4.21.-)Alternative name(s): High-temperature requirement factor A4 |
Gene namesi | Name:HTRA4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169495.4 |
HGNCi | HGNC:26909, HTRA4 |
MIMi | 610700, gene |
neXtProti | NX_P83105 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 203100 |
OpenTargetsi | ENSG00000169495 |
PharmGKBi | PA134862039 |
Miscellaneous databases
Pharosi | P83105, Tbio |
Polymorphism and mutation databases
BioMutai | HTRA4 |
DMDMi | 17366421 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000026951 | 32 – 476 | Serine protease HTRA4Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 108 ↔ 127 | PROSITE-ProRule annotation | ||
Disulfide bondi | 116 ↔ 152 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P83105 |
MassIVEi | P83105 |
PaxDbi | P83105 |
PeptideAtlasi | P83105 |
PRIDEi | P83105 |
ProteomicsDBi | 57730 |
PTM databases
iPTMneti | P83105 |
PhosphoSitePlusi | P83105 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169495, Expressed in placenta and 93 other tissues |
Genevisiblei | P83105, HS |
Organism-specific databases
HPAi | ENSG00000169495, Tissue enriched (placenta) |
Interactioni
Binary interactionsi
Hide detailsP83105
GO - Molecular functioni
- identical protein binding Source: IntAct
- insulin-like growth factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 128450, 11 interactors |
IntActi | P83105, 16 interactors |
STRINGi | 9606.ENSP00000305919 |
Miscellaneous databases
RNActi | P83105, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 99 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 88 – 154 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 383 – 474 | PDZPROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 202 – 362 | Serine proteaseAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the peptidase S1C family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RMZV, Eukaryota |
GeneTreei | ENSGT00940000160760 |
HOGENOMi | CLU_020120_6_2_1 |
InParanoidi | P83105 |
OMAi | NQQWIEV |
OrthoDBi | 630723at2759 |
PhylomeDBi | P83105 |
TreeFami | TF323480 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001478, PDZ IPR036034, PDZ_sf IPR009003, Peptidase_S1_PA IPR001940, Peptidase_S1C |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF07648, Kazal_2, 1 hit PF13180, PDZ_2, 1 hit |
PRINTSi | PR00834, PROTEASES2C |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF50156, SSF50156, 1 hit SSF50494, SSF50494, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS51465, KAZAL_2, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P83105-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRPQLRTAG LGRCLLPGLL LLLVPVLWAG AEKLHTQPSC PAVCQPTRCP
60 70 80 90 100
ALPTCALGTT PVFDLCRCCR VCPAAEREVC GGAQGQPCAP GLQCLQPLRP
110 120 130 140 150
GFPSTCGCPT LGGAVCGSDR RTYPSMCALR AENRAARRLG KVPAVPVQWG
160 170 180 190 200
NCGDTGTRSA GPLRRNYNFI AAVVEKVAPS VVHVQLWGRL LHGSRLVPVY
210 220 230 240 250
SGSGFIVSED GLIITNAHVV RNQQWIEVVL QNGARYEAVV KDIDLKLDLA
260 270 280 290 300
VIKIESNAEL PVLMLGRSSD LRAGEFVVAL GSPFSLQNTA TAGIVSTKQR
310 320 330 340 350
GGKELGMKDS DMDYVQIDAT INYGNSGGPL VNLDGDVIGV NSLRVTDGIS
360 370 380 390 400
FAIPSDRVRQ FLAEYHEHQM KGKAFSNKKY LGLQMLSLTV PLSEELKMHY
410 420 430 440 450
PDFPDVSSGV YVCKVVEGTA AQSSGLRDHD VIVNINGKPI TTTTDVVKAL
460 470
DSDSLSMAVL RGKDNLLLTV IPETIN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 416 | V → F in AAH57765 (PubMed:16421571).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075205 mRNA Translation: BAC11470.1 AC108863 Genomic DNA No translation available. BC057765 mRNA Translation: AAH57765.1 |
CCDSi | CCDS6110.1 |
RefSeqi | NP_710159.1, NM_153692.3 |
Genome annotation databases
Ensembli | ENST00000302495; ENSP00000305919; ENSG00000169495 |
GeneIDi | 203100 |
KEGGi | hsa:203100 |
UCSCi | uc003xmj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075205 mRNA Translation: BAC11470.1 AC108863 Genomic DNA No translation available. BC057765 mRNA Translation: AAH57765.1 |
CCDSi | CCDS6110.1 |
RefSeqi | NP_710159.1, NM_153692.3 |
3D structure databases
SMRi | P83105 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128450, 11 interactors |
IntActi | P83105, 16 interactors |
STRINGi | 9606.ENSP00000305919 |
Protein family/group databases
MEROPSi | S01.285 |
PTM databases
iPTMneti | P83105 |
PhosphoSitePlusi | P83105 |
Polymorphism and mutation databases
BioMutai | HTRA4 |
DMDMi | 17366421 |
Proteomic databases
jPOSTi | P83105 |
MassIVEi | P83105 |
PaxDbi | P83105 |
PeptideAtlasi | P83105 |
PRIDEi | P83105 |
ProteomicsDBi | 57730 |
Protocols and materials databases
Antibodypediai | 23738, 105 antibodies |
Genome annotation databases
Ensembli | ENST00000302495; ENSP00000305919; ENSG00000169495 |
GeneIDi | 203100 |
KEGGi | hsa:203100 |
UCSCi | uc003xmj.4, human |
Organism-specific databases
CTDi | 203100 |
DisGeNETi | 203100 |
EuPathDBi | HostDB:ENSG00000169495.4 |
GeneCardsi | HTRA4 |
HGNCi | HGNC:26909, HTRA4 |
HPAi | ENSG00000169495, Tissue enriched (placenta) |
MIMi | 610700, gene |
neXtProti | NX_P83105 |
OpenTargetsi | ENSG00000169495 |
PharmGKBi | PA134862039 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RMZV, Eukaryota |
GeneTreei | ENSGT00940000160760 |
HOGENOMi | CLU_020120_6_2_1 |
InParanoidi | P83105 |
OMAi | NQQWIEV |
OrthoDBi | 630723at2759 |
PhylomeDBi | P83105 |
TreeFami | TF323480 |
Enzyme and pathway databases
PathwayCommonsi | P83105 |
Miscellaneous databases
BioGRID-ORCSi | 203100, 4 hits in 843 CRISPR screens |
GenomeRNAii | 203100 |
Pharosi | P83105, Tbio |
PROi | PR:P83105 |
RNActi | P83105, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169495, Expressed in placenta and 93 other tissues |
Genevisiblei | P83105, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR001478, PDZ IPR036034, PDZ_sf IPR009003, Peptidase_S1_PA IPR001940, Peptidase_S1C |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF07648, Kazal_2, 1 hit PF13180, PDZ_2, 1 hit |
PRINTSi | PR00834, PROTEASES2C |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF50156, SSF50156, 1 hit SSF50494, SSF50494, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS51465, KAZAL_2, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HTRA4_HUMAN | |
Accessioni | P83105Primary (citable) accession number: P83105 Secondary accession number(s): Q542Z4, Q6PF13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | October 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries