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Protein

Putative glycogen synthase kinase-3 homolog

Gene

gskt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 47ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • male gamete generation Source: FlyBase
  • protein phosphorylation Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
SignaLinkiP83101

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycogen synthase kinase-3 homolog (EC:2.7.11.26)
Short name:
GSK-3
Alternative name(s):
Protein gasket
Gene namesi
Name:gskt
ORF Names:CG31003
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0046332 gskt

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859841 – 501Putative glycogen synthase kinase-3 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylation on Tyr-193 is necessary for the activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP83101
PRIDEiP83101

Expressioni

Gene expression databases

BgeeiFBgn0046332 Expressed in 7 organ(s), highest expression level in testis
GenevisibleiP83101 DM

Interactioni

Protein-protein interaction databases

BioGridi76872, 2 interactors
IntActiP83101, 2 interactors
STRINGi7227.FBpp0085145

Structurei

3D structure databases

ProteinModelPortaliP83101
SMRiP83101
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 317Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi452 – 499Asp-richAdd BLAST48

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00520000055635
InParanoidiP83101
KOiK03083
OMAiCHSIGIC
OrthoDBiEOG091G099S
PhylomeDBiP83101

Family and domain databases

CDDicd14137 STKc_GSK3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P83101-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQSKNSGL TNKVTTVVAT NAFGADVMSE ISYTDAKVVG NGSFGVVFQA
60 70 80 90 100
KMVPSNEMVA IKKVLQDRRF KNRELQIMRK LRHDNIITLK WFFFSSGEKR
110 120 130 140 150
DEVYLNLVME FLPETLYKVE RQYARAKQTL PVNFVRLYMY QLLRSMGYLH
160 170 180 190 200
SLGFCHRDIK PQNMLLDSET GVLKLCDFGS AKQLISGEPN VSYICSRYYR
210 220 230 240 250
APELIFGSTD YTTKIDMWSA GCVMSELLLG QLIFPGDSGV DQIVEIVKVM
260 270 280 290 300
GTPTSEQLHD MNPHYKQFKL PELKPHPWSK VFRIRTPAEA IDLVSKMLIY
310 320 330 340 350
SPNARVSPLM GCAHPFFDEL RQDPHQQLPN GRSLPPLFNF TDYEKTIEPD
360 370 380 390 400
TMPLLLPRAQ GSSTTKEPSA AHRNRNTAGE ESPRKTEDSQ KPATAALSKS
410 420 430 440 450
PGPSGKALES PPGFLQHDLG NGDHVAVGTM PMEPLTLEQN HFAAESYAVG
460 470 480 490 500
EDAEDNLEED VGDENDYDYD DGGQCNSTYI SDDMDEASES DDDDFEEEDE

N
Length:501
Mass (Da):56,237
Last modified:October 1, 2001 - v1
Checksum:i949DBCADBD72A2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN14270.1
BT001338 mRNA Translation: AAN71093.1
RefSeqiNP_733426.1, NM_170547.3
UniGeneiDm.14965

Genome annotation databases

EnsemblMetazoaiFBtr0085784; FBpp0085145; FBgn0046332
GeneIDi318552
KEGGidme:Dmel_CG31003
UCSCiCG31003-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN14270.1
BT001338 mRNA Translation: AAN71093.1
RefSeqiNP_733426.1, NM_170547.3
UniGeneiDm.14965

3D structure databases

ProteinModelPortaliP83101
SMRiP83101
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi76872, 2 interactors
IntActiP83101, 2 interactors
STRINGi7227.FBpp0085145

Proteomic databases

PaxDbiP83101
PRIDEiP83101

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085784; FBpp0085145; FBgn0046332
GeneIDi318552
KEGGidme:Dmel_CG31003
UCSCiCG31003-RA d. melanogaster

Organism-specific databases

CTDi318552
FlyBaseiFBgn0046332 gskt

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00520000055635
InParanoidiP83101
KOiK03083
OMAiCHSIGIC
OrthoDBiEOG091G099S
PhylomeDBiP83101

Enzyme and pathway databases

ReactomeiR-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
SignaLinkiP83101

Miscellaneous databases

GenomeRNAii318552
PROiPR:P83101

Gene expression databases

BgeeiFBgn0046332 Expressed in 7 organ(s), highest expression level in testis
GenevisibleiP83101 DM

Family and domain databases

CDDicd14137 STKc_GSK3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSK3H_DROME
AccessioniPrimary (citable) accession number: P83101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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