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Protein

Alpha-(1,3)-fucosyltransferase C

Gene

FucTC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: GO_Central
  • fucosyltransferase activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase C (EC:2.4.1.-)
Alternative name(s):
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FucTC
ORF Names:CG40305
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0044872 FucTC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 425LumenalSequence analysisAdd BLAST367

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211231 – 425Alpha-(1,3)-fucosyltransferase CAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP83088
PRIDEiP83088

Expressioni

Gene expression databases

BgeeiFBgn0044872
ExpressionAtlasiP83088 baseline and differential
GenevisibleiP83088 DM

Interactioni

Protein-protein interaction databases

BioGridi78296, 1 interactor
IntActiP83088, 2 interactors
STRINGi7227.FBpp0289204

Structurei

3D structure databases

ProteinModelPortaliP83088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
InParanoidiP83088
KOiK14464
OMAiCEITNQH
OrthoDBiEOG091G088Y
PhylomeDBiP83088

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequencei

Sequence statusi: Complete.

P83088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLGRVHCSF EVPGLLSGRV GHMSMAVRSV RLACGPRGAL LLLLLVLLGV
60 70 80 90 100
LVVLHKVTQS PLLNQNKILQ DHLRGQHERY IQSTRTILLW TEFFGDSRWK
110 120 130 140 150
LSWDTLGPQE LRDELHCPVY QCEISNQNAF LPAVELYDAI VFHAAEMFPL
160 170 180 190 200
LRPVPSQRSP HQVYVFALME PPGETKHRLD DEQGFYNLTM TYRIDSDVFW
210 220 230 240 250
PYGQLLDITA DAVVAPSVKP PWRKPPVAFN DSLVWDLWSG KTKTAAWFVS
260 270 280 290 300
HCETLSKREV LANRLQEFFE VDIYGNCGTL SCTRGDPHCA EMLDTDYFFY
310 320 330 340 350
LAFENSLCDD YVTEKLFDAL ERTVIPVVFG GADYSRILPP HSYVDANRFM
360 370 380 390 400
SVEGLAQYMK LVVADPDLYV SYFWWRSHYR LTYSSPFCDL CARLHDPSFG
410 420
HKTQFYHDIQ SWWFNSCRLQ SRIRL
Length:425
Mass (Da):49,130
Last modified:April 18, 2012 - v4
Checksum:i0E037B103ACF2EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302047 mRNA Translation: CAC41643.1
AE014298 Genomic DNA Translation: EAA46057.5
RefSeqiNP_001036320.3, NM_001042855.4
UniGeneiDm.4690

Genome annotation databases

EnsemblMetazoaiFBtr0299926; FBpp0289204; FBgn0044872
GeneIDi3355171
KEGGidme:Dmel_CG40305
UCSCiCG40305-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiFUCTC_DROME
AccessioniPrimary (citable) accession number: P83088
Secondary accession number(s): Q7PLF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: April 18, 2012
Last modified: July 18, 2018
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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