UniProtKB - P83040 (HCY2E_RAPVE)
Protein
Hemocyanin type 2 unit e
Gene
N/A
Organism
Rapana venosa (Veined rapa whelk) (Rapana thomasiana)
Status
Functioni
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.By similarity
Cofactori
Cu2+Note: Binds 2 copper ions per heterodimer.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 49 | Copper A | 1 | |
Metal bindingi | 69 | Copper A | 1 | |
Metal bindingi | 78 | Copper A | 1 | |
Metal bindingi | 189 | Copper B | 1 | |
Metal bindingi | 193 | Copper B | 1 | |
Metal bindingi | 220 | Copper B | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemocyanin type 2 unit eAlternative name(s): RtH2-e |
Organismi | Rapana venosa (Veined rapa whelk) (Rapana thomasiana) |
Taxonomic identifieri | 55521 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Muricoidea › Muricidae › Rapana |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204307 | 1 – 413 | Hemocyanin type 2 unit eAdd BLAST | 413 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 17 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 | |
Disulfide bondi | 55 ↔ 66 | Combined sources1 Publication | ||
Cross-linki | 67 ↔ 69 | 2'-(S-cysteinyl)-histidine (Cys-His)1 Publication | ||
Glycosylationi | 127 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 | |
Disulfide bondi | 179 ↔ 246 | Combined sources1 Publication | ||
Disulfide bondi | 336 ↔ 342 | Combined sources1 Publication |
Keywords - PTMi
Disulfide bond, Glycoprotein, Thioether bondProteomic databases
PRIDEi | P83040 |
PTM databases
iPTMneti | P83040 |
Expressioni
Tissue specificityi
Hemolymph.Curated
Interactioni
Subunit structurei
Decamers of large identical subunits, each containing 8 globular oxygen-binding functional units.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P83040 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P83040 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.1280.10, 1 hit 2.60.310.10, 1 hit |
InterProi | View protein in InterPro IPR028999, Haemocyanin_beta-sandwich IPR036848, Haemocyanin_C_sf IPR002227, Tyrosinase_Cu-bd IPR008922, Unchr_di-copper_centre |
Pfami | View protein in Pfam PF14830, Haemocyan_bet_s, 1 hit PF00264, Tyrosinase, 1 hit |
PRINTSi | PR00092, TYROSINASE |
SUPFAMi | SSF48056, SSF48056, 1 hit SSF81277, SSF81277, 1 hit |
PROSITEi | View protein in PROSITE PS00497, TYROSINASE_1, 1 hit PS00498, TYROSINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P83040-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DDQGHTHRNL VRKSVRNLSP AERRSLVHAL KSLQEDSSAD GFQSLASFHA
60 70 80 90 100
QPPLCPYPEA NKRFACCVHG MATFPEWHRL YTVQFEDALR RHGSVVGIPY
110 120 130 140 150
WDTVVPQEDL PAFFNDEIWD DPLFHANFTN PFNGADIDFN HQKIARDINV
160 170 180 190 200
DKLFKEGPKG YDTWSFKQYI YALEQEDYCD FEVQFEIAHN AIHAWVGGTE
210 220 230 240 250
EYSMGHLHYA SYDPVFILHH SNTDRLFALW QELQKFRGHD PNEVNCALEM
260 270 280 290 300
MREPLKPFSF GAPYNLNPTT KEHSKPEDTF DYKGHFHYEY DHLELQGMNV
310 320 330 340 350
QRLHDYINQQ KERDRVFAGF LLEGIGTSAH LDFSICKIDG ECTHAGYFDV
360 370 380 390 400
LGGSLETPWQ FDRLYKYEIT DVLESKGLDV HDVFDIKITQ TSWDNEDIST
410
DRFPPPSVIY VPK
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LNL | X-ray | 3.30 | A/B/C | 7-413 | [»] | |
SMRi | P83040 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
PTM databases
iPTMneti | P83040 |
Proteomic databases
PRIDEi | P83040 |
Miscellaneous databases
EvolutionaryTracei | P83040 |
Family and domain databases
Gene3Di | 1.10.1280.10, 1 hit 2.60.310.10, 1 hit |
InterProi | View protein in InterPro IPR028999, Haemocyanin_beta-sandwich IPR036848, Haemocyanin_C_sf IPR002227, Tyrosinase_Cu-bd IPR008922, Unchr_di-copper_centre |
Pfami | View protein in Pfam PF14830, Haemocyan_bet_s, 1 hit PF00264, Tyrosinase, 1 hit |
PRINTSi | PR00092, TYROSINASE |
SUPFAMi | SSF48056, SSF48056, 1 hit SSF81277, SSF81277, 1 hit |
PROSITEi | View protein in PROSITE PS00497, TYROSINASE_1, 1 hit PS00498, TYROSINASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HCY2E_RAPVE | |
Accessioni | P83040Primary (citable) accession number: P83040 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | October 1, 2001 | |
Last modified: | June 17, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families