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Protein

Retinol-binding protein 5

Gene

RBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.1 Publication

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: UniProtKB
  • retinol binding Source: UniProtKB-KW

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Chemistry databases

SwissLipidsiSLP:000001526

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 5
Alternative name(s):
Cellular retinol-binding protein III
Short name:
CRBP-III
HRBPiso
Gene namesi
Name:RBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139194.7
HGNCiHGNC:15847 RBP5
MIMi611866 gene
neXtProtiNX_P82980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi83758
OpenTargetsiENSG00000139194
PharmGKBiPA164742366

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRBP5
DMDMi14916691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674001 – 135Retinol-binding protein 5Add BLAST135

Proteomic databases

PaxDbiP82980
PeptideAtlasiP82980
PRIDEiP82980
ProteomicsDBi57727
TopDownProteomicsiP82980

Expressioni

Tissue specificityi

Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000139194
CleanExiHS_RBP5
ExpressionAtlasiP82980 baseline and differential
GenevisibleiP82980 HS

Organism-specific databases

HPAiHPA038723

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-3941274,EBI-748961

Protein-protein interaction databases

BioGridi123759, 4 interactors
IntActiP82980, 4 interactors
STRINGi9606.ENSP00000266560

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Helixi17 – 23Combined sources7
Turni28 – 33Combined sources6
Helixi34 – 36Combined sources3
Beta strandi40 – 45Combined sources6
Beta strandi47 – 55Combined sources9
Beta strandi61 – 66Combined sources6
Beta strandi71 – 74Combined sources4
Turni76 – 79Combined sources4
Beta strandi82 – 89Combined sources8
Beta strandi91 – 102Combined sources12
Beta strandi106 – 112Combined sources7
Beta strandi115 – 122Combined sources8
Beta strandi125 – 133Combined sources9

3D structure databases

ProteinModelPortaliP82980
SMRiP82980
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82980

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP82980
OMAiGRKCQTT
OrthoDBiEOG091G0QSV
PhylomeDBiP82980
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031270 CRBP-III
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF74 PTHR11955:SF74, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

P82980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNLTGYYR FVSQKNMEDY LQALNISLAV RKIALLLKPD KEIEHQGNHM
60 70 80 90 100
TVRTLSTFRN YTVQFDVGVE FEEDLRSVDG RKCQTIVTWE EEHLVCVQKG
110 120 130
EVPNRGWRHW LEGEMLYLEL TARDAVCEQV FRKVR
Length:135
Mass (Da):15,931
Last modified:January 23, 2007 - v3
Checksum:iB9D059DCCC0A88ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04901319D → N. Corresponds to variant dbSNP:rs10963Ensembl.1
Natural variantiVAR_03444570E → Q. Corresponds to variant dbSNP:rs7969705Ensembl.1
Natural variantiVAR_034446115M → L2 PublicationsCorresponds to variant dbSNP:rs2290237Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007436 mRNA Translation: AAG09617.1
AF212239 mRNA Translation: AAK14925.1
AK311977 mRNA Translation: BAG34916.1
AK223378 mRNA Translation: BAD97098.1
BC029355 mRNA Translation: AAH29355.1
CCDSiCCDS8574.1
RefSeqiNP_113679.1, NM_031491.3
UniGeneiHs.246046

Genome annotation databases

EnsembliENST00000266560; ENSP00000266560; ENSG00000139194
GeneIDi83758
KEGGihsa:83758
UCSCiuc001qsq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRET5_HUMAN
AccessioniPrimary (citable) accession number: P82980
Secondary accession number(s): Q53FB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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