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Protein

SAP domain-containing ribonucleoprotein

Gene

SARNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processmRNA transport, Transcription, Transcription regulation, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
SAP domain-containing ribonucleoprotein
Alternative name(s):
Cytokine-induced protein of 29 kDa
Nuclear protein Hcc-1
Proliferation-associated cytokine-inducible protein CIP29
Gene namesi
Name:SARNP
Synonyms:HCC1
ORF Names:HSPC316
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000205323.8
HGNCiHGNC:24432 SARNP
MIMi610049 gene
neXtProtiNX_P82979

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84324
OpenTargetsiENSG00000205323
PharmGKBiPA165513309

Polymorphism and mutation databases

BioMutaiSARNP
DMDMi18202440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000839162 – 210SAP domain-containing ribonucleoproteinAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP82979
MaxQBiP82979
PaxDbiP82979
PeptideAtlasiP82979
PRIDEiP82979
ProteomicsDBi57726
TopDownProteomicsiP82979

PTM databases

iPTMnetiP82979
PhosphoSitePlusiP82979

Expressioni

Tissue specificityi

Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.1 Publication

Inductioni

By EPO/erythropoietin.

Gene expression databases

BgeeiENSG00000205323 Expressed in 175 organ(s), highest expression level in testis
ExpressionAtlasiP82979 baseline and differential
GenevisibleiP82979 HS

Organism-specific databases

HPAiHPA030902
HPA030903

Interactioni

Subunit structurei

Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which bridges it to ALYREF/THOC4.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi124049, 77 interactors
IntActiP82979, 16 interactors
MINTiP82979
STRINGi9606.ENSP00000337632

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP82979
SMRiP82979
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82979

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 42SAPPROSITE-ProRule annotationAdd BLAST35

Phylogenomic databases

eggNOGiKOG4259 Eukaryota
ENOG4111IA4 LUCA
GeneTreeiENSGT00390000002944
HOGENOMiHOG000013054
InParanoidiP82979
KOiK18732
PhylomeDBiP82979
TreeFamiTF319843

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P82979-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATETVELHK LKLAELKQEC LARGLETKGI KQDLIHRLQA YLEEHAEEEA
60 70 80 90 100
NEEDVLGDET EEEETKPIEL PVKEEEPPEK TVDVAAEKKV VKITSEIPQT
110 120 130 140 150
ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD NKPMVNLDKL
160 170 180 190 200
KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK
210
RKRAERFGIA
Length:210
Mass (Da):23,671
Last modified:January 23, 2007 - v3
Checksum:i96AFDD37EA328126
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZQ9F8VZQ9_HUMAN
SAP domain-containing ribonucleopro...
SARNP
213Annotation score:
F8VS12F8VS12_HUMAN
SAP domain-containing ribonucleopro...
SARNP
52Annotation score:

Sequence cautioni

The sequence AAF28994 differs from that shown. Reason: Frameshift at positions 134 and 149.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127F → V in AAF28994 (PubMed:11042152).Curated1
Sequence conflicti153 – 157RAQRF → ELKDL in AAF28994 (PubMed:11042152).Curated5
Sequence conflicti199 – 210KKRKR…RFGIA → RRGKEQSALGLP in AAF28994 (PubMed:11042152).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409089 Genomic DNA Translation: CAC37950.1
AF486281 mRNA Translation: AAM09686.1
AF161434 mRNA Translation: AAF28994.1 Sequence problems.
AK290508 mRNA Translation: BAF83197.1
CH471054 Genomic DNA Translation: EAW96838.1
BC007099 mRNA Translation: AAH07099.1
CCDSiCCDS8892.1
PIRiJC7830
RefSeqiNP_149073.1, NM_033082.3
UniGeneiHs.505676

Genome annotation databases

EnsembliENST00000336133; ENSP00000337632; ENSG00000205323
ENST00000546604; ENSP00000449409; ENSG00000205323
GeneIDi84324
KEGGihsa:84324
UCSCiuc001sht.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409089 Genomic DNA Translation: CAC37950.1
AF486281 mRNA Translation: AAM09686.1
AF161434 mRNA Translation: AAF28994.1 Sequence problems.
AK290508 mRNA Translation: BAF83197.1
CH471054 Genomic DNA Translation: EAW96838.1
BC007099 mRNA Translation: AAH07099.1
CCDSiCCDS8892.1
PIRiJC7830
RefSeqiNP_149073.1, NM_033082.3
UniGeneiHs.505676

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DO1NMR-A6-47[»]
ProteinModelPortaliP82979
SMRiP82979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124049, 77 interactors
IntActiP82979, 16 interactors
MINTiP82979
STRINGi9606.ENSP00000337632

PTM databases

iPTMnetiP82979
PhosphoSitePlusiP82979

Polymorphism and mutation databases

BioMutaiSARNP
DMDMi18202440

Proteomic databases

EPDiP82979
MaxQBiP82979
PaxDbiP82979
PeptideAtlasiP82979
PRIDEiP82979
ProteomicsDBi57726
TopDownProteomicsiP82979

Protocols and materials databases

DNASUi84324
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336133; ENSP00000337632; ENSG00000205323
ENST00000546604; ENSP00000449409; ENSG00000205323
GeneIDi84324
KEGGihsa:84324
UCSCiuc001sht.4 human

Organism-specific databases

CTDi84324
DisGeNETi84324
EuPathDBiHostDB:ENSG00000205323.8
GeneCardsiSARNP
HGNCiHGNC:24432 SARNP
HPAiHPA030902
HPA030903
MIMi610049 gene
neXtProtiNX_P82979
OpenTargetsiENSG00000205323
PharmGKBiPA165513309
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4259 Eukaryota
ENOG4111IA4 LUCA
GeneTreeiENSGT00390000002944
HOGENOMiHOG000013054
InParanoidiP82979
KOiK18732
PhylomeDBiP82979
TreeFamiTF319843

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSARNP human
EvolutionaryTraceiP82979
GeneWikiiCIP29
GenomeRNAii84324
PROiPR:P82979
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205323 Expressed in 175 organ(s), highest expression level in testis
ExpressionAtlasiP82979 baseline and differential
GenevisibleiP82979 HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSARNP_HUMAN
AccessioniPrimary (citable) accession number: P82979
Secondary accession number(s): A8K393, Q9P066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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