UniProtKB - P82970 (HMGN5_HUMAN)
Protein
High mobility group nucleosome-binding domain-containing protein 5
Gene
HMGN5
Organism
Homo sapiens (Human)
Status
Functioni
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- nucleosomal DNA binding Source: InterPro
- RNA binding Source: UniProtKB
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- negative regulation of apoptotic process Source: CACAO
- negative regulation of cell cycle arrest Source: CACAO
- positive regulation of cell population proliferation Source: CACAO
- positive regulation of gene expression Source: CACAO
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P82970 |
Names & Taxonomyi
Protein namesi | Recommended name: High mobility group nucleosome-binding domain-containing protein 5Alternative name(s): Nucleosome-binding protein 1 |
Gene namesi | Name:HMGN5 Synonyms:NSBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8013, HMGN5 |
MIMi | 300385, gene |
neXtProti | NX_P82970 |
VEuPathDBi | HostDB:ENSG00000198157.10 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.By similarity
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79366 |
OpenTargetsi | ENSG00000198157 |
PharmGKBi | PA31789 |
Miscellaneous databases
Pharosi | P82970, Tbio |
Genetic variation databases
BioMutai | HMGN5 |
DMDMi | 23396771 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206717 | 1 – 282 | High mobility group nucleosome-binding domain-containing protein 5Add BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 67 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 76 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 93 | PhosphoserineCombined sources | 1 | |
Cross-linki | 101 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 101 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 124 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P82970 |
jPOSTi | P82970 |
MassIVEi | P82970 |
MaxQBi | P82970 |
PaxDbi | P82970 |
PeptideAtlasi | P82970 |
PRIDEi | P82970 |
ProteomicsDBi | 57725 |
TopDownProteomicsi | P82970 |
PTM databases
iPTMneti | P82970 |
MetOSitei | P82970 |
PhosphoSitePlusi | P82970 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000198157, Expressed in right testis and 193 other tissues |
ExpressionAtlasi | P82970, baseline and differential |
Genevisiblei | P82970, HS |
Organism-specific databases
HPAi | ENSG00000198157, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122655, 20 interactors |
IntActi | P82970, 8 interactors |
STRINGi | 9606.ENSP00000350848 |
Miscellaneous databases
RNActi | P82970, protein |
Family & Domainsi
Domaini
Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity
Sequence similaritiesi
Belongs to the HMGN family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQGX, Eukaryota |
GeneTreei | ENSGT00730000111570 |
HOGENOMi | CLU_082746_0_0_1 |
InParanoidi | P82970 |
OMAi | KEDGHAP |
OrthoDBi | 1581874at2759 |
PhylomeDBi | P82970 |
Family and domain databases
InterProi | View protein in InterPro IPR040164, HMGN5 IPR000079, HMGN_fam |
PANTHERi | PTHR23145, PTHR23145, 1 hit |
Pfami | View protein in Pfam PF01101, HMG14_17, 1 hit |
PRINTSi | PR00925, NONHISHMG17 |
SMARTi | View protein in SMART SM00527, HMG17, 1 hit |
PROSITEi | View protein in PROSITE PS00355, HMG14_17, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P82970-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD
60 70 80 90 100
MMEENIDTSA QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV
110 120 130 140 150
KEENIEDATE KGGEKKEAVA AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD
160 170 180 190 200
EKGEEDGKED KNGNEKGEDA KEKEDGKKGE DGKGNGEDGK EKGEDEKEEE
210 220 230 240 250
DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE DEGGNEEEAG
260 270 280
KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JSK9 | Q5JSK9_HUMAN | High mobility group nucleosome-bind... | HMGN5 | 201 | Annotation score: | ||
Q5JSL0 | Q5JSL0_HUMAN | High mobility group nucleosome-bind... | HMGN5 | 148 | Annotation score: | ||
Q5JSK6 | Q5JSK6_HUMAN | High mobility group nucleosome-bind... | HMGN5 | 161 | Annotation score: | ||
Q5JSK8 | Q5JSK8_HUMAN | High mobility group nucleosome-bind... | HMGN5 | 102 | Annotation score: | ||
Q5JSK7 | Q5JSK7_HUMAN | High mobility group nucleosome-bind... | HMGN5 | 89 | Annotation score: |
Sequence cautioni
The sequence AK094058 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250329 mRNA Translation: AAK14062.1 AF250330 Genomic DNA Translation: AAK14063.1 AK094058 mRNA No translation available. AL391294 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98582.1 BC005342 mRNA Translation: AAH05342.1 |
CCDSi | CCDS14448.1 |
RefSeqi | NP_110390.1, NM_030763.2 |
Genome annotation databases
Ensembli | ENST00000358130; ENSP00000350848; ENSG00000198157 |
GeneIDi | 79366 |
KEGGi | hsa:79366 |
UCSCi | uc004eee.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250329 mRNA Translation: AAK14062.1 AF250330 Genomic DNA Translation: AAK14063.1 AK094058 mRNA No translation available. AL391294 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98582.1 BC005342 mRNA Translation: AAH05342.1 |
CCDSi | CCDS14448.1 |
RefSeqi | NP_110390.1, NM_030763.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122655, 20 interactors |
IntActi | P82970, 8 interactors |
STRINGi | 9606.ENSP00000350848 |
PTM databases
iPTMneti | P82970 |
MetOSitei | P82970 |
PhosphoSitePlusi | P82970 |
Genetic variation databases
BioMutai | HMGN5 |
DMDMi | 23396771 |
Proteomic databases
EPDi | P82970 |
jPOSTi | P82970 |
MassIVEi | P82970 |
MaxQBi | P82970 |
PaxDbi | P82970 |
PeptideAtlasi | P82970 |
PRIDEi | P82970 |
ProteomicsDBi | 57725 |
TopDownProteomicsi | P82970 |
Protocols and materials databases
Antibodypediai | 391, 128 antibodies |
DNASUi | 79366 |
Genome annotation databases
Ensembli | ENST00000358130; ENSP00000350848; ENSG00000198157 |
GeneIDi | 79366 |
KEGGi | hsa:79366 |
UCSCi | uc004eee.1, human |
Organism-specific databases
CTDi | 79366 |
DisGeNETi | 79366 |
GeneCardsi | HMGN5 |
HGNCi | HGNC:8013, HMGN5 |
HPAi | ENSG00000198157, Tissue enhanced (testis) |
MIMi | 300385, gene |
neXtProti | NX_P82970 |
OpenTargetsi | ENSG00000198157 |
PharmGKBi | PA31789 |
VEuPathDBi | HostDB:ENSG00000198157.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQGX, Eukaryota |
GeneTreei | ENSGT00730000111570 |
HOGENOMi | CLU_082746_0_0_1 |
InParanoidi | P82970 |
OMAi | KEDGHAP |
OrthoDBi | 1581874at2759 |
PhylomeDBi | P82970 |
Enzyme and pathway databases
PathwayCommonsi | P82970 |
Miscellaneous databases
BioGRID-ORCSi | 79366, 52 hits in 487 CRISPR screens |
ChiTaRSi | HMGN5, human |
GenomeRNAii | 79366 |
Pharosi | P82970, Tbio |
PROi | PR:P82970 |
RNActi | P82970, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198157, Expressed in right testis and 193 other tissues |
ExpressionAtlasi | P82970, baseline and differential |
Genevisiblei | P82970, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040164, HMGN5 IPR000079, HMGN_fam |
PANTHERi | PTHR23145, PTHR23145, 1 hit |
Pfami | View protein in Pfam PF01101, HMG14_17, 1 hit |
PRINTSi | PR00925, NONHISHMG17 |
SMARTi | View protein in SMART SM00527, HMG17, 1 hit |
PROSITEi | View protein in PROSITE PS00355, HMG14_17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMGN5_HUMAN | |
Accessioni | P82970Primary (citable) accession number: P82970 Secondary accession number(s): Q5JSL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families