UniProtKB - P82970 (HMGN5_HUMAN)

BLAST

>sp|P82970|HMGN5_HUMAN High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1
MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSA
QAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVA
AEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGE
DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKE
DEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

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History
Entry version 145 (07 Nov 2018)
Sequence version 1 (01 Jun 2001)
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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

HMGN5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 11161810
nucleosomal DNA binding Source: InterPro
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization Source: UniProtKB-KW
negative regulation of apoptotic process
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20531280
negative regulation of cell cycle arrest
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20531280
positive regulation of cell proliferation
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20531280
positive regulation of gene expression
Source: CACAO
Inferred from mutant phenotypeⁱ
- 20531280
positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 11161810
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 11161810

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: High mobility group nucleosome-binding domain-containing protein 5 Alternative name(s): Nucleosome-binding protein 1
Gene namesⁱ	Name:HMGN5 Synonyms:NSBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198157.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8013 HMGN5
MIMⁱ	300385 gene
neXtProtⁱ	NX_P82970

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79366
Open Targets More...OpenTargetsⁱ	ENSG00000198157
PharmGKBⁱ	PA31789

Polymorphism and mutation databases

BioMutaⁱ	HMGN5
DMDMⁱ	23396771

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206717	1 – 282	High mobility group nucleosome-binding domain-containing protein 5Add BLAST		282

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	31	PhosphothreonineCombined sources	1
Cross-linkⁱ	67	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	76	PhosphotyrosineCombined sources	1
Modified residueⁱ	93	PhosphoserineCombined sources	1
Cross-linkⁱ	101	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	101	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	124	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P82970
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P82970
PaxDbⁱ	P82970
PeptideAtlas More...PeptideAtlasⁱ	P82970
PRIDEⁱ	P82970
ProteomicsDBⁱ	57725
TopDownProteomicsⁱ	P82970

PTM databases

iPTMnetⁱ	P82970
PhosphoSitePlusⁱ	P82970

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198157 Expressed in 182 organ(s), highest expression level in right testis
CleanExⁱ	HS_NSBP1
ExpressionAtlasⁱ	P82970 baseline and differential
Genevisibleⁱ	P82970 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000511

HPAⁱ

HPA000511

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122655, 16 interactors
IntActⁱ	P82970, 1 interactor
STRINGⁱ	9606.ENSP00000350848

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P82970
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesⁱ

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410JCH1 Eukaryota ENOG410XQBG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111570
HOGENOMⁱ	HOG000113856
HOVERGENⁱ	HBG094823
InParanoidⁱ	P82970
KEGG Orthology (KO) More...KOⁱ	K17045
OMAⁱ	KEDGHAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12C3
PhylomeDBⁱ	P82970

Family and domain databases

InterProⁱ	View protein in InterPro IPR000079 HMGN_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01101 HMG14_17, 1 hit
PRINTSⁱ	PR00925 NONHISHMG17
SMARTⁱ	View protein in SMART SM00527 HMG17, 1 hit
PROSITEⁱ	View protein in PROSITE PS00355 HMG14_17, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P82970-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD 
        60         70         80         90        100
MMEENIDTSA QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV 
       110        120        130        140        150
KEENIEDATE KGGEKKEAVA AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD 
       160        170        180        190        200
EKGEEDGKED KNGNEKGEDA KEKEDGKKGE DGKGNGEDGK EKGEDEKEEE 
       210        220        230        240        250
DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE DEGGNEEEAG 
       260        270        280 
KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV

Length:282

Mass (Da):31,525

Last modified:June 1, 2001 - v1

Checksum:ⁱ257A2B22C795308F

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JSL0	Q5JSL0_HUMAN	High mobility group nucleosome-bind... High mobility group nucleosome-binding domain-containing protein 5	HMGN5	148	Annotation score:
Q5JSK6	Q5JSK6_HUMAN	High mobility group nucleosome-bind... High mobility group nucleosome-binding domain-containing protein 5	HMGN5	161	Annotation score:
Q5JSK9	Q5JSK9_HUMAN	High mobility group nucleosome-bind... High mobility group nucleosome-binding domain-containing protein 5	HMGN5	201	Annotation score:
Q5JSK8	Q5JSK8_HUMAN	High mobility group nucleosome-bind... High mobility group nucleosome-binding domain-containing protein 5	HMGN5	102	Annotation score:
Q5JSK7	Q5JSK7_HUMAN	High mobility group nucleosome-bind... High mobility group nucleosome-binding domain-containing protein 5	HMGN5	89	Annotation score:

Sequence cautionⁱ

The sequence AK094058 differs from that shown. Reason: Frameshift at position 132.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF250329 mRNA Translation: AAK14062.1 AF250330 Genomic DNA Translation: AAK14063.1 AK094058 mRNA No translation available. AL391294 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98582.1 BC005342 mRNA Translation: AAH05342.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14448.1
NCBI Reference Sequences More...RefSeqⁱ	NP_110390.1, NM_030763.2
UniGeneⁱ	Hs.282204

Genome annotation databases

Ensemblⁱ	ENST00000358130; ENSP00000350848; ENSG00000198157
GeneIDⁱ	79366
KEGGⁱ	hsa:79366
UCSC genome browser More...UCSCⁱ	uc004eee.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P82970	High mobility group nucleosome-binding domain-containing protein 5 (Fragment)		HUMAN		89	UniRef100_P82970
HMGN5 isoform 3 (Fragment)		PANTR		89
High mobility group nucleosome-binding domain-containing protein 5 (Fragment)		HUMAN		102
HMGN5 isoform 2 (Fragment)		PANTR		102
High mobility group nucleosome-binding domain-containing protein 5 (Fragment)		HUMAN		148

Protein	Similar proteins		Species	Score	Length	Source
P82970	High mobility group nucleosome-binding domain-containing protein 5 (Fragment)		HUMAN		89	UniRef90_P82970
HMGN5 isoform 3 (Fragment)		PANTR		89
Uncharacterized protein		MACMU		289
Nucleosome-binding protein 1 (Fragment)		MACFA		284
Uncharacterized protein		CERAT		289
+30

Protein	Similar proteins		Species	Score	Length	Source
P82970	High mobility group nucleosome-binding domain-containing protein 5 (Fragment)		HUMAN		89	UniRef50_P82970
HMGN5 isoform 3 (Fragment)		PANTR		89
Uncharacterized protein		MACFA		289
Uncharacterized protein		MACMU		289
Uncharacterized protein		PAPAN		289
+49

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF250329 mRNA Translation: AAK14062.1 AF250330 Genomic DNA Translation: AAK14063.1 AK094058 mRNA No translation available. AL391294 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98582.1 BC005342 mRNA Translation: AAH05342.1
CCDSⁱ	CCDS14448.1
RefSeqⁱ	NP_110390.1, NM_030763.2
UniGeneⁱ	Hs.282204

3D structure databases

ProteinModelPortalⁱ	P82970
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122655, 16 interactors
IntActⁱ	P82970, 1 interactor
STRINGⁱ	9606.ENSP00000350848

PTM databases

iPTMnetⁱ	P82970
PhosphoSitePlusⁱ	P82970

Polymorphism and mutation databases

BioMutaⁱ	HMGN5
DMDMⁱ	23396771

Proteomic databases

EPDⁱ	P82970
MaxQBⁱ	P82970
PaxDbⁱ	P82970
PeptideAtlasⁱ	P82970
PRIDEⁱ	P82970
ProteomicsDBⁱ	57725
TopDownProteomicsⁱ	P82970

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79366
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000358130; ENSP00000350848; ENSG00000198157
GeneIDⁱ	79366
KEGGⁱ	hsa:79366
UCSCⁱ	uc004eee.1 human

Organism-specific databases

CTDⁱ	79366
DisGeNETⁱ	79366
EuPathDBⁱ	HostDB:ENSG00000198157.10
GeneCardsⁱ	HMGN5
HGNCⁱ	HGNC:8013 HMGN5
HPAⁱ	HPA000511
MIMⁱ	300385 gene
neXtProtⁱ	NX_P82970
OpenTargetsⁱ	ENSG00000198157
PharmGKBⁱ	PA31789
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JCH1 Eukaryota ENOG410XQBG LUCA
GeneTreeⁱ	ENSGT00730000111570
HOGENOMⁱ	HOG000113856
HOVERGENⁱ	HBG094823
InParanoidⁱ	P82970
KOⁱ	K17045
OMAⁱ	KEDGHAP
OrthoDBⁱ	EOG091G12C3
PhylomeDBⁱ	P82970

Miscellaneous databases

ChiTaRSⁱ	HMGN5 human
GenomeRNAiⁱ	79366
Protein Ontology More...PROⁱ	PR:P82970
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198157 Expressed in 182 organ(s), highest expression level in right testis
CleanExⁱ	HS_NSBP1
ExpressionAtlasⁱ	P82970 baseline and differential
Genevisibleⁱ	P82970 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000079 HMGN_fam
Pfamⁱ	View protein in Pfam PF01101 HMG14_17, 1 hit
PRINTSⁱ	PR00925 NONHISHMG17
SMARTⁱ	View protein in SMART SM00527 HMG17, 1 hit
PROSITEⁱ	View protein in PROSITE PS00355 HMG14_17, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMGN5_HUMAN
Accessionⁱ	P82970Primary (citable) accession number: P82970 Secondary accession number(s): Q5JSL1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - P82970 (HMGN5_HUMAN)

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High mobility group nucleosome-binding domain-containing protein 5

HMGN5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ