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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

HMGN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • nucleosomal DNA binding Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 1
Gene namesi
Name:HMGN5
Synonyms:NSBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198157.10
HGNCiHGNC:8013 HMGN5
MIMi300385 gene
neXtProtiNX_P82970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79366
OpenTargetsiENSG00000198157
PharmGKBiPA31789

Polymorphism and mutation databases

BioMutaiHMGN5
DMDMi23396771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067171 – 282High mobility group nucleosome-binding domain-containing protein 5Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphothreonineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei76PhosphotyrosineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP82970
MaxQBiP82970
PaxDbiP82970
PeptideAtlasiP82970
PRIDEiP82970
ProteomicsDBi57725
TopDownProteomicsiP82970

PTM databases

iPTMnetiP82970
PhosphoSitePlusiP82970

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000198157 Expressed in 182 organ(s), highest expression level in right testis
CleanExiHS_NSBP1
ExpressionAtlasiP82970 baseline and differential
GenevisibleiP82970 HS

Organism-specific databases

HPAiHPA000511

Interactioni

Protein-protein interaction databases

BioGridi122655, 16 interactors
IntActiP82970, 1 interactor
STRINGi9606.ENSP00000350848

Structurei

3D structure databases

ProteinModelPortaliP82970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410JCH1 Eukaryota
ENOG410XQBG LUCA
GeneTreeiENSGT00730000111570
HOGENOMiHOG000113856
HOVERGENiHBG094823
InParanoidiP82970
KOiK17045
OMAiKEDGHAP
OrthoDBiEOG091G12C3
PhylomeDBiP82970

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P82970-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD
60 70 80 90 100
MMEENIDTSA QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV
110 120 130 140 150
KEENIEDATE KGGEKKEAVA AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD
160 170 180 190 200
EKGEEDGKED KNGNEKGEDA KEKEDGKKGE DGKGNGEDGK EKGEDEKEEE
210 220 230 240 250
DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE DEGGNEEEAG
260 270 280
KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV
Length:282
Mass (Da):31,525
Last modified:June 1, 2001 - v1
Checksum:i257A2B22C795308F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JSL0Q5JSL0_HUMAN
High mobility group nucleosome-bind...
HMGN5
148Annotation score:
Q5JSK6Q5JSK6_HUMAN
High mobility group nucleosome-bind...
HMGN5
161Annotation score:
Q5JSK9Q5JSK9_HUMAN
High mobility group nucleosome-bind...
HMGN5
201Annotation score:
Q5JSK8Q5JSK8_HUMAN
High mobility group nucleosome-bind...
HMGN5
102Annotation score:
Q5JSK7Q5JSK7_HUMAN
High mobility group nucleosome-bind...
HMGN5
89Annotation score:

Sequence cautioni

The sequence AK094058 differs from that shown. Reason: Frameshift at position 132.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250329 mRNA Translation: AAK14062.1
AF250330 Genomic DNA Translation: AAK14063.1
AK094058 mRNA No translation available.
AL391294 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98582.1
BC005342 mRNA Translation: AAH05342.1
CCDSiCCDS14448.1
RefSeqiNP_110390.1, NM_030763.2
UniGeneiHs.282204

Genome annotation databases

EnsembliENST00000358130; ENSP00000350848; ENSG00000198157
GeneIDi79366
KEGGihsa:79366
UCSCiuc004eee.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250329 mRNA Translation: AAK14062.1
AF250330 Genomic DNA Translation: AAK14063.1
AK094058 mRNA No translation available.
AL391294 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98582.1
BC005342 mRNA Translation: AAH05342.1
CCDSiCCDS14448.1
RefSeqiNP_110390.1, NM_030763.2
UniGeneiHs.282204

3D structure databases

ProteinModelPortaliP82970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122655, 16 interactors
IntActiP82970, 1 interactor
STRINGi9606.ENSP00000350848

PTM databases

iPTMnetiP82970
PhosphoSitePlusiP82970

Polymorphism and mutation databases

BioMutaiHMGN5
DMDMi23396771

Proteomic databases

EPDiP82970
MaxQBiP82970
PaxDbiP82970
PeptideAtlasiP82970
PRIDEiP82970
ProteomicsDBi57725
TopDownProteomicsiP82970

Protocols and materials databases

DNASUi79366
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358130; ENSP00000350848; ENSG00000198157
GeneIDi79366
KEGGihsa:79366
UCSCiuc004eee.1 human

Organism-specific databases

CTDi79366
DisGeNETi79366
EuPathDBiHostDB:ENSG00000198157.10
GeneCardsiHMGN5
HGNCiHGNC:8013 HMGN5
HPAiHPA000511
MIMi300385 gene
neXtProtiNX_P82970
OpenTargetsiENSG00000198157
PharmGKBiPA31789
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCH1 Eukaryota
ENOG410XQBG LUCA
GeneTreeiENSGT00730000111570
HOGENOMiHOG000113856
HOVERGENiHBG094823
InParanoidiP82970
KOiK17045
OMAiKEDGHAP
OrthoDBiEOG091G12C3
PhylomeDBiP82970

Miscellaneous databases

ChiTaRSiHMGN5 human
GenomeRNAii79366
PROiPR:P82970
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198157 Expressed in 182 organ(s), highest expression level in right testis
CleanExiHS_NSBP1
ExpressionAtlasiP82970 baseline and differential
GenevisibleiP82970 HS

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN5_HUMAN
AccessioniPrimary (citable) accession number: P82970
Secondary accession number(s): Q5JSL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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