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Protein

28S ribosomal protein S9, mitochondrial

Gene

MRPS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S9, mitochondrial
Short name:
MRP-S9
Short name:
S9mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS9m1 Publication
Gene namesi
Name:MRPS9
Synonyms:RPMS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135972.8
HGNCiHGNC:14501 MRPS9
MIMi611975 gene
neXtProtiNX_P82933

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135972
PharmGKBiPA31028

Polymorphism and mutation databases

BioMutaiMRPS9
DMDMi218511769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030655? – 39628S ribosomal protein S9, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP82933
MaxQBiP82933
PaxDbiP82933
PeptideAtlasiP82933
PRIDEiP82933
ProteomicsDBi57724
TopDownProteomicsiP82933

PTM databases

iPTMnetiP82933
PhosphoSitePlusiP82933
SwissPalmiP82933

Expressioni

Gene expression databases

BgeeiENSG00000135972 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_MRPS9
ExpressionAtlasiP82933 baseline and differential
GenevisibleiP82933 HS

Organism-specific databases

HPAiHPA043476
HPA048479

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046182EBI-721385,EBI-6164309From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi122360, 134 interactors
CORUMiP82933
IntActiP82933, 36 interactors
MINTiP82933
STRINGi9606.ENSP00000258455

Structurei

3D structure databases

ProteinModelPortaliP82933
SMRiP82933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1697 Eukaryota
COG0103 LUCA
GeneTreeiENSGT00390000011204
HOGENOMiHOG000020877
HOVERGENiHBG023132
InParanoidiP82933
KOiK02996
OMAiRPVMKHP
OrthoDBiEOG091G14QI
PhylomeDBiP82933
TreeFamiTF106154

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR000754 Ribosomal_S9
IPR020574 Ribosomal_S9_CS
PANTHERiPTHR21569 PTHR21569, 1 hit
PfamiView protein in Pfam
PF00380 Ribosomal_S9, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00360 RIBOSOMAL_S9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P82933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR
60 70 80 90 100
HTAFVIPKKN VPTSKRETYT EDFIKKQIEE FNIGKRHLAN MMGEDPETFT
110 120 130 140 150
QEDIDRAIAY LFPSGLFEKR ARPVMKHPEQ IFPRQRAIQW GEDGRPFHYL
160 170 180 190 200
FYTGKQSYYS LMHDVYGMLL NLEKHQSHLQ AKSLLPEKTV TRDVIGSRWL
210 220 230 240 250
IKEELEEMLV EKLSDLDYMQ FIRLLEKLLT SQCGAAEEEF VQRFRRSVTL
260 270 280 290 300
ESKKQLIEPV QYDEQGMAFS KSEGKRKTAK AEAIVYKHGS GRIKVNGIDY
310 320 330 340 350
QLYFPITQDR EQLMFPFHFV DRLGKHDVTC TVSGGGRSAQ AGAIRLAMAK
360 370 380 390
ALCSFVTEDE VEWMRQAGLL TTDPRVRERK KPGQEGARRK FTWKKR
Length:396
Mass (Da):45,835
Last modified:December 16, 2008 - v2
Checksum:i74412E34F0926360
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZC4H7BZC4_HUMAN
28S ribosomal protein S9, mitochond...
MRPS9
57Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04790213S → L. Corresponds to variant dbSNP:rs13399067Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010884 Genomic DNA No translation available.
AC107080 Genomic DNA No translation available.
AC104655 Genomic DNA No translation available.
CH471127 Genomic DNA Translation: EAX01767.1
BC057240 mRNA Translation: AAH57240.1
CCDSiCCDS2065.1
RefSeqiNP_872578.1, NM_182640.2
UniGeneiHs.590900

Genome annotation databases

EnsembliENST00000258455; ENSP00000258455; ENSG00000135972
GeneIDi64965
KEGGihsa:64965
UCSCiuc002tcn.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010884 Genomic DNA No translation available.
AC107080 Genomic DNA No translation available.
AC104655 Genomic DNA No translation available.
CH471127 Genomic DNA Translation: EAX01767.1
BC057240 mRNA Translation: AAH57240.1
CCDSiCCDS2065.1
RefSeqiNP_872578.1, NM_182640.2
UniGeneiHs.590900

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AG1-396[»]
ProteinModelPortaliP82933
SMRiP82933
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122360, 134 interactors
CORUMiP82933
IntActiP82933, 36 interactors
MINTiP82933
STRINGi9606.ENSP00000258455

PTM databases

iPTMnetiP82933
PhosphoSitePlusiP82933
SwissPalmiP82933

Polymorphism and mutation databases

BioMutaiMRPS9
DMDMi218511769

Proteomic databases

EPDiP82933
MaxQBiP82933
PaxDbiP82933
PeptideAtlasiP82933
PRIDEiP82933
ProteomicsDBi57724
TopDownProteomicsiP82933

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258455; ENSP00000258455; ENSG00000135972
GeneIDi64965
KEGGihsa:64965
UCSCiuc002tcn.5 human

Organism-specific databases

CTDi64965
EuPathDBiHostDB:ENSG00000135972.8
GeneCardsiMRPS9
HGNCiHGNC:14501 MRPS9
HPAiHPA043476
HPA048479
MIMi611975 gene
neXtProtiNX_P82933
OpenTargetsiENSG00000135972
PharmGKBiPA31028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1697 Eukaryota
COG0103 LUCA
GeneTreeiENSGT00390000011204
HOGENOMiHOG000020877
HOVERGENiHBG023132
InParanoidiP82933
KOiK02996
OMAiRPVMKHP
OrthoDBiEOG091G14QI
PhylomeDBiP82933
TreeFamiTF106154

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS9 human
GenomeRNAii64965
PROiPR:P82933
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135972 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_MRPS9
ExpressionAtlasiP82933 baseline and differential
GenevisibleiP82933 HS

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR000754 Ribosomal_S9
IPR020574 Ribosomal_S9_CS
PANTHERiPTHR21569 PTHR21569, 1 hit
PfamiView protein in Pfam
PF00380 Ribosomal_S9, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00360 RIBOSOMAL_S9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT09_HUMAN
AccessioniPrimary (citable) accession number: P82933
Secondary accession number(s): Q6PG40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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