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Entry version 170 (03 Jul 2019)
Sequence version 3 (23 Jan 2007)
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Protein

28S ribosomal protein S6, mitochondrial

Gene

MRPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
28S ribosomal protein S6, mitochondrial
Short name:
MRP-S6
Short name:
S6mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS6m1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRPS6
Synonyms:C21orf101, RPMS6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14051 MRPS6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611973 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P82932

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64968

Open Targets

More...
OpenTargetsi
ENSG00000243927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31025

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRPS6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13959558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001768921 – 12528S ribosomal protein S6, mitochondrialAdd BLAST125

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P82932

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P82932

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P82932

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P82932

PeptideAtlas

More...
PeptideAtlasi
P82932

PRoteomics IDEntifications database

More...
PRIDEi
P82932

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57723

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P82932

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P82932

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P82932

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243927 Expressed in 209 organ(s), highest expression level in cortex of kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P82932 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007861
HPA049676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122361, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P82932

Protein interaction database and analysis system

More...
IntActi
P82932, 31 interactors

Molecular INTeraction database

More...
MINTi
P82932

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382250

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P82932

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4708 Eukaryota
COG0360 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045806

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P82932

KEGG Orthology (KO)

More...
KOi
K02990

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKSYPIA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P82932

TreeFam database of animal gene trees

More...
TreeFami
TF314045

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000529 Ribosomal_S6
IPR035980 Ribosomal_S6_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6

The PANTHER Classification System

More...
PANTHERi
PTHR21011 PTHR21011, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01250 Ribosomal_S6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54995 SSF54995, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00166 S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P82932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR
60 70 80 90 100
ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ
110 120
ELKECEGIVP VPLAEKLYST KKRKK
Length:125
Mass (Da):14,227
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65995BB83B76F127
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB40995 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB049942 mRNA Translation: BAB40995.1 Different initiation.
AY061855 mRNA Translation: AAL35739.1
AK312084 mRNA Translation: BAG35020.1
AP001719 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09798.1
BC000547 mRNA Translation: AAH00547.2
BC004976 mRNA Translation: AAH04976.2
BC010076 mRNA Translation: AAH10076.1
BC051302 mRNA Translation: AAH51302.1
AB051347 Genomic DNA Translation: BAB54937.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33548.1

NCBI Reference Sequences

More...
RefSeqi
NP_115865.1, NM_032476.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399312; ENSP00000382250; ENSG00000243927

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64968

UCSC genome browser

More...
UCSCi
uc002ytp.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA Translation: BAB40995.1 Different initiation.
AY061855 mRNA Translation: AAL35739.1
AK312084 mRNA Translation: BAG35020.1
AP001719 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09798.1
BC000547 mRNA Translation: AAH00547.2
BC004976 mRNA Translation: AAH04976.2
BC010076 mRNA Translation: AAH10076.1
BC051302 mRNA Translation: AAH51302.1
AB051347 Genomic DNA Translation: BAB54937.1
CCDSiCCDS33548.1
RefSeqiNP_115865.1, NM_032476.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AE1-125[»]
6NU2electron microscopy3.90AE2-123[»]
6NU3electron microscopy4.40AE1-125[»]
SMRiP82932
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122361, 26 interactors
CORUMiP82932
IntActiP82932, 31 interactors
MINTiP82932
STRINGi9606.ENSP00000382250

PTM databases

iPTMnetiP82932
PhosphoSitePlusiP82932

Polymorphism and mutation databases

BioMutaiMRPS6
DMDMi13959558

Proteomic databases

EPDiP82932
jPOSTiP82932
MaxQBiP82932
PaxDbiP82932
PeptideAtlasiP82932
PRIDEiP82932
ProteomicsDBi57723
TopDownProteomicsiP82932

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64968
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927
GeneIDi64968
KEGGihsa:64968
UCSCiuc002ytp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64968
DisGeNETi64968

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MRPS6
HGNCiHGNC:14051 MRPS6
HPAiHPA007861
HPA049676
MIMi611973 gene
neXtProtiNX_P82932
OpenTargetsiENSG00000243927
PharmGKBiPA31025

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4708 Eukaryota
COG0360 LUCA
GeneTreeiENSGT00390000014606
HOGENOMiHOG000045806
InParanoidiP82932
KOiK02990
OMAiPKSYPIA
PhylomeDBiP82932
TreeFamiTF314045

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MRPS6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MRPS6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64968

Protein Ontology

More...
PROi
PR:P82932

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000243927 Expressed in 209 organ(s), highest expression level in cortex of kidney
GenevisibleiP82932 HS

Family and domain databases

Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR000529 Ribosomal_S6
IPR035980 Ribosomal_S6_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
PANTHERiPTHR21011 PTHR21011, 1 hit
PfamiView protein in Pfam
PF01250 Ribosomal_S6, 1 hit
SUPFAMiSSF54995 SSF54995, 1 hit
TIGRFAMsiTIGR00166 S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRT06_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P82932
Secondary accession number(s): B2R573
, Q96Q64, Q9BSK8, Q9BW89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: January 23, 2007
Last modified: July 3, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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