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Protein

28S ribosomal protein S6, mitochondrial

Gene

MRPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S6, mitochondrial
Short name:
MRP-S6
Short name:
S6mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS6m1 Publication
Gene namesi
Name:MRPS6
Synonyms:C21orf101, RPMS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000243927.5
HGNCiHGNC:14051 MRPS6
MIMi611973 gene
neXtProtiNX_P82932

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64968
OpenTargetsiENSG00000243927
PharmGKBiPA31025

Polymorphism and mutation databases

BioMutaiMRPS6
DMDMi13959558

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001768921 – 12528S ribosomal protein S6, mitochondrialAdd BLAST125

Proteomic databases

EPDiP82932
MaxQBiP82932
PaxDbiP82932
PeptideAtlasiP82932
PRIDEiP82932
ProteomicsDBi57723
TopDownProteomicsiP82932

PTM databases

iPTMnetiP82932
PhosphoSitePlusiP82932

Expressioni

Gene expression databases

BgeeiENSG00000243927 Expressed in 209 organ(s), highest expression level in cortex of kidney
CleanExiHS_MRPS6
GenevisibleiP82932 HS

Organism-specific databases

HPAiHPA007861
HPA049676

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi122361, 23 interactors
CORUMiP82932
IntActiP82932, 28 interactors
MINTiP82932
STRINGi9606.ENSP00000382250

Structurei

3D structure databases

ProteinModelPortaliP82932
SMRiP82932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4708 Eukaryota
COG0360 LUCA
GeneTreeiENSGT00390000014606
HOGENOMiHOG000045806
HOVERGENiHBG082699
InParanoidiP82932
KOiK02990
OMAiPKSYPIA
OrthoDBiEOG091G0W0U
PhylomeDBiP82932
TreeFamiTF314045

Family and domain databases

Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR000529 Ribosomal_S6
IPR035980 Ribosomal_S6_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
PANTHERiPTHR21011 PTHR21011, 1 hit
PfamiView protein in Pfam
PF01250 Ribosomal_S6, 1 hit
SUPFAMiSSF54995 SSF54995, 1 hit
TIGRFAMsiTIGR00166 S6, 1 hit

Sequencei

Sequence statusi: Complete.

P82932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR
60 70 80 90 100
ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ
110 120
ELKECEGIVP VPLAEKLYST KKRKK
Length:125
Mass (Da):14,227
Last modified:January 23, 2007 - v3
Checksum:i65995BB83B76F127
GO

Sequence cautioni

The sequence BAB40995 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA Translation: BAB40995.1 Different initiation.
AY061855 mRNA Translation: AAL35739.1
AK312084 mRNA Translation: BAG35020.1
AP001719 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09798.1
BC000547 mRNA Translation: AAH00547.2
BC004976 mRNA Translation: AAH04976.2
BC010076 mRNA Translation: AAH10076.1
BC051302 mRNA Translation: AAH51302.1
AB051347 Genomic DNA Translation: BAB54937.1
CCDSiCCDS33548.1
RefSeqiNP_115865.1, NM_032476.3
UniGeneiHs.302742

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927
GeneIDi64968
KEGGihsa:64968
UCSCiuc002ytp.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA Translation: BAB40995.1 Different initiation.
AY061855 mRNA Translation: AAL35739.1
AK312084 mRNA Translation: BAG35020.1
AP001719 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09798.1
BC000547 mRNA Translation: AAH00547.2
BC004976 mRNA Translation: AAH04976.2
BC010076 mRNA Translation: AAH10076.1
BC051302 mRNA Translation: AAH51302.1
AB051347 Genomic DNA Translation: BAB54937.1
CCDSiCCDS33548.1
RefSeqiNP_115865.1, NM_032476.3
UniGeneiHs.302742

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AE1-125[»]
ProteinModelPortaliP82932
SMRiP82932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122361, 23 interactors
CORUMiP82932
IntActiP82932, 28 interactors
MINTiP82932
STRINGi9606.ENSP00000382250

PTM databases

iPTMnetiP82932
PhosphoSitePlusiP82932

Polymorphism and mutation databases

BioMutaiMRPS6
DMDMi13959558

Proteomic databases

EPDiP82932
MaxQBiP82932
PaxDbiP82932
PeptideAtlasiP82932
PRIDEiP82932
ProteomicsDBi57723
TopDownProteomicsiP82932

Protocols and materials databases

DNASUi64968
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927
GeneIDi64968
KEGGihsa:64968
UCSCiuc002ytp.2 human

Organism-specific databases

CTDi64968
DisGeNETi64968
EuPathDBiHostDB:ENSG00000243927.5
GeneCardsiMRPS6
HGNCiHGNC:14051 MRPS6
HPAiHPA007861
HPA049676
MIMi611973 gene
neXtProtiNX_P82932
OpenTargetsiENSG00000243927
PharmGKBiPA31025
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4708 Eukaryota
COG0360 LUCA
GeneTreeiENSGT00390000014606
HOGENOMiHOG000045806
HOVERGENiHBG082699
InParanoidiP82932
KOiK02990
OMAiPKSYPIA
OrthoDBiEOG091G0W0U
PhylomeDBiP82932
TreeFamiTF314045

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS6 human
GeneWikiiMRPS6
GenomeRNAii64968
PROiPR:P82932
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243927 Expressed in 209 organ(s), highest expression level in cortex of kidney
CleanExiHS_MRPS6
GenevisibleiP82932 HS

Family and domain databases

Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR000529 Ribosomal_S6
IPR035980 Ribosomal_S6_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
PANTHERiPTHR21011 PTHR21011, 1 hit
PfamiView protein in Pfam
PF01250 Ribosomal_S6, 1 hit
SUPFAMiSSF54995 SSF54995, 1 hit
TIGRFAMsiTIGR00166 S6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT06_HUMAN
AccessioniPrimary (citable) accession number: P82932
Secondary accession number(s): B2R573
, Q96Q64, Q9BSK8, Q9BW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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