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Protein

28S ribosomal protein S21, mitochondrial

Gene

MRPS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S21, mitochondrial
Short name:
MRP-S21
Short name:
S21mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS21m1 Publication
Gene namesi
Name:MRPS21
Synonyms:RPMS21
ORF Names:MDS016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000266472.5
HGNCiHGNC:14046 MRPS21
MIMi611984 gene
neXtProtiNX_P82921

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000266472
PharmGKBiPA31009

Polymorphism and mutation databases

BioMutaiMRPS21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001784131 – 8728S ribosomal protein S21, mitochondrialAdd BLAST87

Proteomic databases

EPDiP82921
PaxDbiP82921
PeptideAtlasiP82921
PRIDEiP82921
ProteomicsDBi57721

PTM databases

iPTMnetiP82921
PhosphoSitePlusiP82921
SwissPalmiP82921

Expressioni

Gene expression databases

BgeeiENSG00000266472 Expressed in 210 organ(s), highest expression level in metanephros
CleanExiHS_MRPS21

Organism-specific databases

HPAiHPA078289

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119966, 50 interactors
CORUMiP82921
IntActiP82921, 15 interactors
MINTiP82921
STRINGi9606.ENSP00000312395

Structurei

3D structure databases

ProteinModelPortaliP82921
SMRiP82921
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1MD Eukaryota
ENOG4111YFB LUCA
GeneTreeiENSGT00500000045038
HOGENOMiHOG000007789
HOVERGENiHBG047411
InParanoidiP82921
KOiK02970
OMAiFVARTVM
PhylomeDBiP82921
TreeFamiTF313903

Family and domain databases

Gene3Di1.20.5.1150, 1 hit
InterProiView protein in InterPro
IPR001911 Ribosomal_S21
IPR038380 S21_sf
PANTHERiPTHR21109 PTHR21109, 1 hit
PfamiView protein in Pfam
PF01165 Ribosomal_S21, 1 hit
TIGRFAMsiTIGR00030 S21p, 1 hit

Sequencei

Sequence statusi: Complete.

P82921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCC
60 70 80
RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC
Length:87
Mass (Da):10,689
Last modified:March 28, 2018 - v3
Checksum:iBCFAEB58D9F7ECAA
GO

Sequence cautioni

The sequence AAG14953 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG14953 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05182550C → R6 PublicationsCorresponds to variant dbSNP:rs10480Ensembl.1
Natural variantiVAR_02461051R → Q. Corresponds to variant dbSNP:rs4845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049955 mRNA Translation: BAB41008.1
AF182417 mRNA Translation: AAG14953.1 Different initiation.
AK289467 mRNA Translation: BAF82156.1
AC242988 Genomic DNA No translation available.
AL138795 Genomic DNA Translation: CAI22820.1
CH471121 Genomic DNA Translation: EAW53558.1
CH471121 Genomic DNA Translation: EAW53559.1
BC004566 mRNA Translation: AAH04566.2
BC006554 mRNA Translation: AAH06554.1
CCDSiCCDS950.1
RefSeqiNP_061870.1, NM_018997.3
NP_114107.1, NM_031901.5
UniGeneiHs.405880

Genome annotation databases

EnsembliENST00000581066; ENSP00000461930; ENSG00000266472
ENST00000614145; ENSP00000480129; ENSG00000266472
GeneIDi54460
KEGGihsa:54460
UCSCiuc001euk.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049955 mRNA Translation: BAB41008.1
AF182417 mRNA Translation: AAG14953.1 Different initiation.
AK289467 mRNA Translation: BAF82156.1
AC242988 Genomic DNA No translation available.
AL138795 Genomic DNA Translation: CAI22820.1
CH471121 Genomic DNA Translation: EAW53558.1
CH471121 Genomic DNA Translation: EAW53559.1
BC004566 mRNA Translation: AAH04566.2
BC006554 mRNA Translation: AAH06554.1
CCDSiCCDS950.1
RefSeqiNP_061870.1, NM_018997.3
NP_114107.1, NM_031901.5
UniGeneiHs.405880

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AQ1-87[»]
ProteinModelPortaliP82921
SMRiP82921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119966, 50 interactors
CORUMiP82921
IntActiP82921, 15 interactors
MINTiP82921
STRINGi9606.ENSP00000312395

PTM databases

iPTMnetiP82921
PhosphoSitePlusiP82921
SwissPalmiP82921

Polymorphism and mutation databases

BioMutaiMRPS21

Proteomic databases

EPDiP82921
PaxDbiP82921
PeptideAtlasiP82921
PRIDEiP82921
ProteomicsDBi57721

Protocols and materials databases

DNASUi54460
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581066; ENSP00000461930; ENSG00000266472
ENST00000614145; ENSP00000480129; ENSG00000266472
GeneIDi54460
KEGGihsa:54460
UCSCiuc001euk.5 human

Organism-specific databases

CTDi54460
EuPathDBiHostDB:ENSG00000266472.5
GeneCardsiMRPS21
HGNCiHGNC:14046 MRPS21
HPAiHPA078289
MIMi611984 gene
neXtProtiNX_P82921
OpenTargetsiENSG00000266472
PharmGKBiPA31009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1MD Eukaryota
ENOG4111YFB LUCA
GeneTreeiENSGT00500000045038
HOGENOMiHOG000007789
HOVERGENiHBG047411
InParanoidiP82921
KOiK02970
OMAiFVARTVM
PhylomeDBiP82921
TreeFamiTF313903

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS21 human
GeneWikiiMRPS21
GenomeRNAii54460
PROiPR:P82921
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000266472 Expressed in 210 organ(s), highest expression level in metanephros
CleanExiHS_MRPS21

Family and domain databases

Gene3Di1.20.5.1150, 1 hit
InterProiView protein in InterPro
IPR001911 Ribosomal_S21
IPR038380 S21_sf
PANTHERiPTHR21109 PTHR21109, 1 hit
PfamiView protein in Pfam
PF01165 Ribosomal_S21, 1 hit
TIGRFAMsiTIGR00030 S21p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT21_HUMAN
AccessioniPrimary (citable) accession number: P82921
Secondary accession number(s): A0A075B746, Q5TB11, Q9BST6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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