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Protein

28S ribosomal protein S11, mitochondrial

Gene

MRPS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S11, mitochondrial
Short name:
MRP-S11
Short name:
S11mt
Alternative name(s):
Cervical cancer proto-oncogene 2 protein
Short name:
HCC-2
Mitochondrial small ribosomal subunit protein uS11m1 Publication
Gene namesi
Name:MRPS11
Synonyms:RPMS11
ORF Names:HCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000181991.15
HGNCiHGNC:14050 MRPS11
MIMi611977 gene
neXtProtiNX_P82912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64963
OpenTargetsiENSG00000181991
PharmGKBiPA30994

Polymorphism and mutation databases

BioMutaiMRPS11
DMDMi21263985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030602? – 19428S ribosomal protein S11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiP82912
MaxQBiP82912
PaxDbiP82912
PeptideAtlasiP82912
PRIDEiP82912
ProteomicsDBi57717
57718 [P82912-2]
57719 [P82912-3]

PTM databases

iPTMnetiP82912
PhosphoSitePlusiP82912

Expressioni

Gene expression databases

BgeeiENSG00000181991 Expressed in 224 organ(s), highest expression level in apex of heart
CleanExiHS_MRPS11
ExpressionAtlasiP82912 baseline and differential
GenevisibleiP82912 HS

Organism-specific databases

HPAiHPA043752
HPA050345

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122359, 114 interactors
CORUMiP82912
IntActiP82912, 20 interactors
MINTiP82912
STRINGi9606.ENSP00000317376

Structurei

3D structure databases

ProteinModelPortaliP82912
SMRiP82912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0408 Eukaryota
COG0100 LUCA
GeneTreeiENSGT00390000016068
HOGENOMiHOG000111599
HOVERGENiHBG036124
InParanoidiP82912
KOiK02948
OMAiMQVVRNA
OrthoDBiEOG091G0MCM
PhylomeDBiP82912
TreeFamiTF354231

Family and domain databases

Gene3Di3.30.420.80, 1 hit
HAMAPiMF_01310 Ribosomal_S11, 1 hit
InterProiView protein in InterPro
IPR001971 Ribosomal_S11
IPR018102 Ribosomal_S11_CS
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR11759 PTHR11759, 1 hit
PfamiView protein in Pfam
PF00411 Ribosomal_S11, 1 hit
PROSITEiView protein in PROSITE
PS00054 RIBOSOMAL_S11, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P82912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE
60 70 80 90 100
QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV
110 120 130 140 150
SASNEPLAFA SCGTEGFRNA KKGTGIAAQT AGIAAAARAK QKGVIHIRVV
160 170 180 190
VKGLGPGRLS AMHGLIMGGL EVISITDNTP IPHNGCRPRK ARKL
Length:194
Mass (Da):20,616
Last modified:May 27, 2002 - v2
Checksum:i6DACB8FDDD0194BE
GO
Isoform 2 (identifier: P82912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Show »
Length:193
Mass (Da):20,460
Checksum:iFF411F94C2D45B61
GO
Isoform 3 (identifier: P82912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-94: Missing.

Show »
Length:161
Mass (Da):16,904
Checksum:i3324188DDC2D02BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL99H0YL99_HUMAN
28S ribosomal protein S11, mitochon...
MRPS11
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52N → Y in BAB15381 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05205410R → W. Corresponds to variant dbSNP:rs16941904Ensembl.1
Natural variantiVAR_05205551Q → H. Corresponds to variant dbSNP:rs16941907Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00571923Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_00572062 – 94Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049944 mRNA Translation: BAB40997.1
AF320777 Genomic DNA Translation: AAK97314.1
AK026165 mRNA Translation: BAB15381.1
AK315407 mRNA Translation: BAG37799.1
CH471101 Genomic DNA Translation: EAX02000.1
BC009451 mRNA Translation: AAH09451.1
BC012489 mRNA Translation: AAH12489.1
BC032378 mRNA Translation: AAH32378.1
CCDSiCCDS10342.1 [P82912-1]
CCDS10343.1 [P82912-3]
RefSeqiNP_001308899.1, NM_001321970.1 [P82912-2]
NP_001308901.1, NM_001321972.1
NP_001308902.1, NM_001321973.1
NP_001308903.1, NM_001321974.1
NP_001308905.1, NM_001321976.1
NP_073750.2, NM_022839.4 [P82912-1]
NP_789775.1, NM_176805.3 [P82912-3]
UniGeneiHs.111286

Genome annotation databases

EnsembliENST00000325844; ENSP00000317376; ENSG00000181991 [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991 [P82912-3]
GeneIDi64963
KEGGihsa:64963
UCSCiuc002bml.4 human [P82912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049944 mRNA Translation: BAB40997.1
AF320777 Genomic DNA Translation: AAK97314.1
AK026165 mRNA Translation: BAB15381.1
AK315407 mRNA Translation: BAG37799.1
CH471101 Genomic DNA Translation: EAX02000.1
BC009451 mRNA Translation: AAH09451.1
BC012489 mRNA Translation: AAH12489.1
BC032378 mRNA Translation: AAH32378.1
CCDSiCCDS10342.1 [P82912-1]
CCDS10343.1 [P82912-3]
RefSeqiNP_001308899.1, NM_001321970.1 [P82912-2]
NP_001308901.1, NM_001321972.1
NP_001308902.1, NM_001321973.1
NP_001308903.1, NM_001321974.1
NP_001308905.1, NM_001321976.1
NP_073750.2, NM_022839.4 [P82912-1]
NP_789775.1, NM_176805.3 [P82912-3]
UniGeneiHs.111286

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AI1-194[»]
ProteinModelPortaliP82912
SMRiP82912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122359, 114 interactors
CORUMiP82912
IntActiP82912, 20 interactors
MINTiP82912
STRINGi9606.ENSP00000317376

PTM databases

iPTMnetiP82912
PhosphoSitePlusiP82912

Polymorphism and mutation databases

BioMutaiMRPS11
DMDMi21263985

Proteomic databases

EPDiP82912
MaxQBiP82912
PaxDbiP82912
PeptideAtlasiP82912
PRIDEiP82912
ProteomicsDBi57717
57718 [P82912-2]
57719 [P82912-3]

Protocols and materials databases

DNASUi64963
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325844; ENSP00000317376; ENSG00000181991 [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991 [P82912-3]
GeneIDi64963
KEGGihsa:64963
UCSCiuc002bml.4 human [P82912-1]

Organism-specific databases

CTDi64963
DisGeNETi64963
EuPathDBiHostDB:ENSG00000181991.15
GeneCardsiMRPS11
HGNCiHGNC:14050 MRPS11
HPAiHPA043752
HPA050345
MIMi611977 gene
neXtProtiNX_P82912
OpenTargetsiENSG00000181991
PharmGKBiPA30994
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0408 Eukaryota
COG0100 LUCA
GeneTreeiENSGT00390000016068
HOGENOMiHOG000111599
HOVERGENiHBG036124
InParanoidiP82912
KOiK02948
OMAiMQVVRNA
OrthoDBiEOG091G0MCM
PhylomeDBiP82912
TreeFamiTF354231

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS11 human
GeneWikiiMRPS11
GenomeRNAii64963
PROiPR:P82912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181991 Expressed in 224 organ(s), highest expression level in apex of heart
CleanExiHS_MRPS11
ExpressionAtlasiP82912 baseline and differential
GenevisibleiP82912 HS

Family and domain databases

Gene3Di3.30.420.80, 1 hit
HAMAPiMF_01310 Ribosomal_S11, 1 hit
InterProiView protein in InterPro
IPR001971 Ribosomal_S11
IPR018102 Ribosomal_S11_CS
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR11759 PTHR11759, 1 hit
PfamiView protein in Pfam
PF00411 Ribosomal_S11, 1 hit
PROSITEiView protein in PROSITE
PS00054 RIBOSOMAL_S11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT11_HUMAN
AccessioniPrimary (citable) accession number: P82912
Secondary accession number(s): B2RD52
, Q969D7, Q96GI3, Q9BYC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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