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Protein

Major heat shock 70 kDa protein Aa

Gene

Hsp70Aa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two copies of the gene coding for this protein at chromosome locus 87A7.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Aa
Short name:
Heat shock protein 70Aa
Alternative name(s):
HSP70-87A7
Gene namesi
Name:Hsp70Aa
Synonyms:Hsp70A
ORF Names:CG31366
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013275 Hsp70Aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783291 – 642Major heat shock 70 kDa protein AaAdd BLAST642

Proteomic databases

PaxDbiP82910
PRIDEiP82910

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013275 Expressed in 2 organ(s), highest expression level in adult organism
GenevisibleiP82910 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi69381, 46 interactors
71511, 57 interactors
DIPiDIP-19548N
STRINGi7227.FBpp0081986

Structurei

3D structure databases

ProteinModelPortaliP82910
SMRiP82910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00930000150862
InParanoidiP82910
KOiK03283
OMAiESKCRIP
OrthoDBiEOG091G03SF
PhylomeDBiP82910

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P82910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA DEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQD
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYA DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQA
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNDTIRWLDS NTTAEKEEFD HKLEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAGAGGPG ANCGQQAGGF GGYSGPTVEE VD
Length:642
Mass (Da):70,160
Last modified:April 13, 2004 - v2
Checksum:iEC08E94412E27F84
GO

Sequence cautioni

The sequence AAM49826 differs from that shown. Reason: Frameshift at position 144.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139 – 143Missing in AAM49826 (PubMed:12537569).Curated5
Sequence conflicti371A → P in AAM49826 (PubMed:12537569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti69R → G in strain: 3CPA2. 1
Natural varianti441Y → S in strain: FrV3-1. 1
Natural varianti495K → T in strain: QD18. 1
Natural varianti593L → M in strain: 122. 1
Natural varianti615Missing in strain: 122. 1
Natural varianti636P → R in strain: QD18. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295933 Genomic DNA Translation: AAG26887.1
AF295934 Genomic DNA Translation: AAG26888.1
AF295935 Genomic DNA Translation: AAG26889.1
AF295936 Genomic DNA Translation: AAG26890.1
AF295937 Genomic DNA Translation: AAG26891.1
AF295938 Genomic DNA Translation: AAG26892.1
AF350452 Genomic DNA Translation: AAK30209.1
AF350453 Genomic DNA Translation: AAK30210.1
AF350454 Genomic DNA Translation: AAK30211.1
AF350455 Genomic DNA Translation: AAK30212.1
AF350456 Genomic DNA Translation: AAK30213.1
AF350457 Genomic DNA Translation: AAK30214.1
AF350458 Genomic DNA Translation: AAK30215.1
AF350459 Genomic DNA Translation: AAK30216.1
AE014297 Genomic DNA Translation: AAN13535.1
AY118457 mRNA Translation: AAM49826.1 Frameshift.
BT021339 mRNA Translation: AAX33487.1
RefSeqiNP_524798.2, NM_080059.3
NP_731651.1, NM_169441.2
UniGeneiDm.23375
Dm.31247

Genome annotation databases

EnsemblMetazoaiFBtr0082482; FBpp0081956; FBgn0013276
FBtr0082512; FBpp0081986; FBgn0013275
GeneIDi44920
48581
KEGGidme:Dmel_CG18743
dme:Dmel_CG31366

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295933 Genomic DNA Translation: AAG26887.1
AF295934 Genomic DNA Translation: AAG26888.1
AF295935 Genomic DNA Translation: AAG26889.1
AF295936 Genomic DNA Translation: AAG26890.1
AF295937 Genomic DNA Translation: AAG26891.1
AF295938 Genomic DNA Translation: AAG26892.1
AF350452 Genomic DNA Translation: AAK30209.1
AF350453 Genomic DNA Translation: AAK30210.1
AF350454 Genomic DNA Translation: AAK30211.1
AF350455 Genomic DNA Translation: AAK30212.1
AF350456 Genomic DNA Translation: AAK30213.1
AF350457 Genomic DNA Translation: AAK30214.1
AF350458 Genomic DNA Translation: AAK30215.1
AF350459 Genomic DNA Translation: AAK30216.1
AE014297 Genomic DNA Translation: AAN13535.1
AY118457 mRNA Translation: AAM49826.1 Frameshift.
BT021339 mRNA Translation: AAX33487.1
RefSeqiNP_524798.2, NM_080059.3
NP_731651.1, NM_169441.2
UniGeneiDm.23375
Dm.31247

3D structure databases

ProteinModelPortaliP82910
SMRiP82910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69381, 46 interactors
71511, 57 interactors
DIPiDIP-19548N
STRINGi7227.FBpp0081986

Proteomic databases

PaxDbiP82910
PRIDEiP82910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082482; FBpp0081956; FBgn0013276
FBtr0082512; FBpp0081986; FBgn0013275
GeneIDi44920
48581
KEGGidme:Dmel_CG18743
dme:Dmel_CG31366

Organism-specific databases

CTDi44920
48581
FlyBaseiFBgn0013275 Hsp70Aa

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00930000150862
InParanoidiP82910
KOiK03283
OMAiESKCRIP
OrthoDBiEOG091G03SF
PhylomeDBiP82910

Miscellaneous databases

PROiPR:P82910

Gene expression databases

BgeeiFBgn0013275 Expressed in 2 organ(s), highest expression level in adult organism
GenevisibleiP82910 DM

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP70_DROME
AccessioniPrimary (citable) accession number: P82910
Secondary accession number(s): Q5BI85
, Q8MT04, Q95NG7, Q9BIS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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