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Protein

Low molecular weight phosphotyrosine protein phosphatase 1

Gene

primo-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9NucleophileBy similarity1
Active sitei15By similarity1
Active sitei124Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase 1 (EC:3.1.3.2)
PTPase 1
Gene namesi
Name:primo-1
ORF Names:CG31311
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0040077 primo-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465621 – 155Low molecular weight phosphotyrosine protein phosphatase 1Add BLAST155

Proteomic databases

PaxDbiP82890
PRIDEiP82890

Expressioni

Tissue specificityi

Cone cells and primary pigment cells in developing pupal retina.1 Publication

Developmental stagei

Larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiFBgn0040077
GenevisibleiP82890 DM

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0099893

Structurei

3D structure databases

ProteinModelPortaliP82890
SMRiP82890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3217 Eukaryota
COG0394 LUCA
GeneTreeiENSGT00500000044891
KOiK14394
OMAiAGTGSWH
OrthoDBiEOG091G0P0O
PhylomeDBiP82890

Family and domain databases

InterProiView protein in InterPro
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
IPR002115 Tyr_Pase_low_mol_wt_mml
IPR017867 Tyr_phospatase_low_mol_wt
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
PRINTSiPR00719 LMWPTPASE
PR00720 MAMMALPTPASE
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit

Sequencei

Sequence statusi: Complete.

P82890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKVLMICL GNICRSPIAE VVMVDTLEKA NVKDVEVDSA AIGGWHVGNR
60 70 80 90 100
ADPRAISTLQ KHGLKCTHIV RQIRKQDFSE FDYIFGMDED NMSELRRLAP
110 120 130 140 150
KGSKAELLML GDFGLEKKNR IIEDPYYERG AEGFETAYQQ CVVACAAFMK

ERLQK
Length:155
Mass (Da):17,556
Last modified:March 1, 2001 - v1
Checksum:i26C05D1EC3B1A07C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAN13591.2
AE014297 Genomic DNA Translation: AAO41564.1
RefSeqiNP_001027186.1, NM_001032015.2
NP_001027187.1, NM_001032016.2
UniGeneiDm.4988

Genome annotation databases

EnsemblMetazoaiFBtr0091747; FBpp0099893; FBgn0040077
FBtr0091748; FBpp0099895; FBgn0040077
GeneIDi3772179
KEGGidme:Dmel_CG33748
UCSCiCG33748-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPPAC1_DROME
AccessioniPrimary (citable) accession number: P82890
Secondary accession number(s): A4V2V3, Q9VFR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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