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Protein

Potassium channel toxin kappa-KTx 1.2

Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel blocker.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Aromatic residue of the functional dyadBy similarity1
Sitei19Basic residue of the functional dyadBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 1.21 Publication
Alternative name(s):
Kappa-hefutoxin-21 Publication
Short name:
Kappa-HfTx21 Publication
OrganismiHeterometrus fulvipes (Indian black scorpion)
Taxonomic identifieri141248 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445451 – 23Potassium channel toxin kappa-KTx 1.21 PublicationAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 22By similarity
Disulfide bondi8 ↔ 18By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP82851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012630 Toxin_25
PfamiView protein in Pfam
PF08095 Toxin_25, 1 hit

Sequencei

Sequence statusi: Complete.

P82851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
GHACYRNCWR EGNDEETCKE RCG
Length:23
Mass (Da):2,717
Last modified:March 1, 2001 - v1
Checksum:iA61FB555EB877C6E
GO

Mass spectrometryi

Molecular mass is 2713.3±0.5 Da from positions 1 - 23. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ATSX-ray1.90A1-23[»]
SMRiP82851
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012630 Toxin_25
PfamiView protein in Pfam
PF08095 Toxin_25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKKX12_HETFU
AccessioniPrimary (citable) accession number: P82851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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