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Protein

Potassium channel toxin kappa-KTx 1.1

Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Slows the activation kinetics of Kv1.3/KCNA3 currents, and blocks Kv1.3/KCNA3 and Kv1.2/KCNA2 potassium channels. This block is dose-dependent, voltage-independent, and reversible.1 Publication

Miscellaneous

This toxin does not have effect on Kv1.1/KCNA1 currents.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Aromatic residue of the functional dyad1 Publication1
Sitei19Basic residue of the functional dyad1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBi8.B.2.1.1 the short scorpion toxin (s-st) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 1.11 Publication
Alternative name(s):
Kappa-hefutoxin-11 Publication
Short name:
Kappa-HfTx11 Publication
OrganismiHeterometrus fulvipes (Indian black scorpion)
Taxonomic identifieri141248 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5Y → A: Loss of ability to block potassium channels. Same effect observed; when associated with A-19. 1 Publication1
Mutagenesisi19K → A: Loss of ability to block potassium channels. Same effect observed; when associated with A-5. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445441 – 22Potassium channel toxin kappa-KTx 1.11 PublicationAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 221 Publication
Disulfide bondi8 ↔ 181 Publication
Modified residuei22Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP82850
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82850

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).1 Publication

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012630 Toxin_25
PfamiView protein in Pfam
PF08095 Toxin_25, 1 hit

Sequencei

Sequence statusi: Complete.

P82850-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
GHACYRNCWR EGNDEETCKE RC
Length:22
Mass (Da):2,660
Last modified:March 1, 2001 - v1
Checksum:i8FB555EB877C6E98
GO

Mass spectrometryi

Molecular mass is 2655.4±0.2 Da from positions 1 - 22. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HP9NMR-A1-22[»]
SMRiP82850
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.2.1.1 the short scorpion toxin (s-st) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP82850

Family and domain databases

InterProiView protein in InterPro
IPR012630 Toxin_25
PfamiView protein in Pfam
PF08095 Toxin_25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKKX11_HETFU
AccessioniPrimary (citable) accession number: P82850
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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