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Protein

28S ribosomal protein S5, mitochondrial

Gene

MRPS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S5, mitochondrial
Short name:
MRP-S5
Short name:
S5mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS5m1 Publication
Gene namesi
Name:MRPS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144029.11
HGNCiHGNC:14498 MRPS5
MIMi611972 gene
neXtProtiNX_P82675

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144029
PharmGKBiPA31024

Polymorphism and mutation databases

BioMutaiMRPS5
DMDMi24212347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001316851 – 43028S ribosomal protein S5, mitochondrialAdd BLAST430

Proteomic databases

EPDiP82675
MaxQBiP82675
PaxDbiP82675
PeptideAtlasiP82675
PRIDEiP82675
ProteomicsDBi57714
57715 [P82675-2]

PTM databases

iPTMnetiP82675
PhosphoSitePlusiP82675

Expressioni

Gene expression databases

BgeeiENSG00000144029 Expressed in 202 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_MRPS5
GenevisibleiP82675 HS

Organism-specific databases

HPAiHPA055765

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122362, 118 interactors
CORUMiP82675
IntActiP82675, 21 interactors
MINTiP82675
STRINGi9606.ENSP00000272418

Structurei

3D structure databases

ProteinModelPortaliP82675
SMRiP82675
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 282S5 DRBMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2646 Eukaryota
COG0098 LUCA
GeneTreeiENSGT00390000001878
HOGENOMiHOG000231482
HOVERGENiHBG030178
InParanoidiP82675
KOiK02988
OMAiGSVNMLN
OrthoDBiEOG091G09JG
PhylomeDBiP82675
TreeFamiTF313823

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P82675-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS
60 70 80 90 100
SLGTRDTHPY ASLSRALQTQ CCISSPSHLM SQQYRPYSFF TKLTADELWK
110 120 130 140 150
GALAETGAGA KKGRGKRTKK KKRKDLNRGQ IIGEGRYGFL WPGLNVPLMK
160 170 180 190 200
NGAVQTIAQR SKEEQEKVEA DMIQQREEWD RKKKMKVKRE RGWSGNSWGG
210 220 230 240 250
ISLGPPDPGP CGETYEDFDT RILEVRNVFT MTAKEGRKKS IRVLVAVGNG
260 270 280 290 300
KGAAGFSIGK ATDRMDAFRK AKNRAVHHLH YIERYEDHTI FHDISLRFKR
310 320 330 340 350
THIKMKKQPK GYGLRCHRAI ITICRLIGIK DMYAKVSGSI NMLSLTQGLF
360 370 380 390 400
RGLSRQETHQ QLADKKGLHV VEIREECGPL PIVVASPRGP LRKDPEPEDE
410 420 430
VPDVKLDWED VKTAQGMKRS VWSNLKRAAT
Length:430
Mass (Da):48,006
Last modified:October 19, 2002 - v2
Checksum:i80588064E2AB3E97
GO
Isoform 2 (identifier: P82675-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-251: RNVFTMTAKEGRKKSIRVLVAVGNGK → FLLGKLLIGWMLSGKQRTEQFTICII
     252-430: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:251
Mass (Da):27,767
Checksum:i4AFFA624301469B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005725226 – 251RNVFT…VGNGK → FLLGKLLIGWMLSGKQRTEQ FTICII in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_005726252 – 430Missing in isoform 2. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049940 mRNA Translation: BAB40993.1
AK058160 mRNA Translation: BAB71695.1
AC092835 Genomic DNA Translation: AAX88980.1
CH471219 Genomic DNA Translation: EAX10712.1
BC000219 mRNA Translation: AAH00219.2
BC014172 mRNA Translation: AAH14172.1
CCDSiCCDS2010.1 [P82675-1]
RefSeqiNP_114108.1, NM_031902.4 [P82675-1]
UniGeneiHs.655259

Genome annotation databases

EnsembliENST00000272418; ENSP00000272418; ENSG00000144029 [P82675-1]
ENST00000345084; ENSP00000341660; ENSG00000144029 [P82675-2]
GeneIDi64969
KEGGihsa:64969
UCSCiuc002sub.4 human [P82675-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049940 mRNA Translation: BAB40993.1
AK058160 mRNA Translation: BAB71695.1
AC092835 Genomic DNA Translation: AAX88980.1
CH471219 Genomic DNA Translation: EAX10712.1
BC000219 mRNA Translation: AAH00219.2
BC014172 mRNA Translation: AAH14172.1
CCDSiCCDS2010.1 [P82675-1]
RefSeqiNP_114108.1, NM_031902.4 [P82675-1]
UniGeneiHs.655259

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AD1-430[»]
ProteinModelPortaliP82675
SMRiP82675
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122362, 118 interactors
CORUMiP82675
IntActiP82675, 21 interactors
MINTiP82675
STRINGi9606.ENSP00000272418

PTM databases

iPTMnetiP82675
PhosphoSitePlusiP82675

Polymorphism and mutation databases

BioMutaiMRPS5
DMDMi24212347

Proteomic databases

EPDiP82675
MaxQBiP82675
PaxDbiP82675
PeptideAtlasiP82675
PRIDEiP82675
ProteomicsDBi57714
57715 [P82675-2]

Protocols and materials databases

DNASUi64969
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272418; ENSP00000272418; ENSG00000144029 [P82675-1]
ENST00000345084; ENSP00000341660; ENSG00000144029 [P82675-2]
GeneIDi64969
KEGGihsa:64969
UCSCiuc002sub.4 human [P82675-1]

Organism-specific databases

CTDi64969
EuPathDBiHostDB:ENSG00000144029.11
GeneCardsiMRPS5
HGNCiHGNC:14498 MRPS5
HPAiHPA055765
MIMi611972 gene
neXtProtiNX_P82675
OpenTargetsiENSG00000144029
PharmGKBiPA31024
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2646 Eukaryota
COG0098 LUCA
GeneTreeiENSGT00390000001878
HOGENOMiHOG000231482
HOVERGENiHBG030178
InParanoidiP82675
KOiK02988
OMAiGSVNMLN
OrthoDBiEOG091G09JG
PhylomeDBiP82675
TreeFamiTF313823

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS5 human
GeneWikiiMRPS5
GenomeRNAii64969
PROiPR:P82675
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144029 Expressed in 202 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_MRPS5
GenevisibleiP82675 HS

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT05_HUMAN
AccessioniPrimary (citable) accession number: P82675
Secondary accession number(s): Q4ZFY5
, Q96LJ6, Q9BWI4, Q9BYC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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