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Protein

28S ribosomal protein S35, mitochondrial

Gene

MRPS35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Alternative name(s):
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Mitochondrial small ribosomal subunit protein mS351 Publication
Gene namesi
Name:MRPS35Imported
Synonyms:MRPS281 Publication
ORF Names:HDCMD11P, MDS023, PSEC0213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000061794.12
HGNCiHGNC:16635 MRPS35
MIMi611995 gene
neXtProtiNX_P82673

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000061794
PharmGKBiPA31022

Polymorphism and mutation databases

BioMutaiMRPS35
DMDMi74708095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000046055? – 32328S ribosomal protein S35, mitochondrial
Transit peptidei1 – ?MitochondrionCurated

Proteomic databases

EPDiP82673
MaxQBiP82673
PaxDbiP82673
PeptideAtlasiP82673
PRIDEiP82673
ProteomicsDBi57712
57713 [P82673-2]

PTM databases

iPTMnetiP82673
PhosphoSitePlusiP82673

Expressioni

Gene expression databases

BgeeiENSG00000061794 Expressed in 226 organ(s), highest expression level in corpus callosum
CleanExiHS_MRPS28
HS_MRPS35
ExpressionAtlasiP82673 baseline and differential
GenevisibleiP82673 HS

Organism-specific databases

HPAiHPA038513

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi121919, 102 interactors
CORUMiP82673
IntActiP82673, 36 interactors
MINTiP82673
STRINGi9606.ENSP00000081029

Structurei

3D structure databases

ProteinModelPortaliP82673
SMRiP82673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili257 – 321Sequence analysisAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG3933 Eukaryota
ENOG410ZX0Y LUCA
GeneTreeiENSGT00390000003443
HOVERGENiHBG082941
InParanoidiP82673
KOiK17413
OMAiYANAELM
OrthoDBiEOG091G0ELS
PhylomeDBiP82673
TreeFamiTF318686

Family and domain databases

InterProiView protein in InterPro
IPR039848 Ribosomal_S24/S35
IPR019349 Ribosomal_S24/S35_mit
PANTHERiPTHR13490 PTHR13490, 1 hit
PfamiView protein in Pfam
PF10213 MRP-S28, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: P82673-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR
60 70 80 90 100
KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGYP VKKGVPMAKE
110 120 130 140 150
GNLELLKIPN FLHLTPVAIK KHCEALKDFC TEWPAALDSD EKCEKHFPIE
160 170 180 190 200
IDSTDYVSSG PSVRNPRARV VVLRVKLSSL NLDDHAKKKL IKLVGERYCK
210 220 230 240 250
TTDVLTIKTD RCPLRRQNYD YAVYLLTVLY HESWNTEEWE KSKTEADMEE
260 270 280 290 300
YIWENSSSER NILETLLQMK AAEKNMEINK EELLGTKEIE EYKKSVVSLK
310 320
NEEENENSIS QYKESVKRLL NVT
Length:323
Mass (Da):36,844
Last modified:October 1, 2000 - v1
Checksum:iB29F819E914F2B49
GO
Isoform 2Curated (identifier: P82673-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-194: KLSSLNLDDHAKKKLIKLV → PFKEAELRLCSVSTNSVIP
     195-323: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:194
Mass (Da):21,390
Checksum:i69648AE388E7995A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YG82H0YG82_HUMAN
28S ribosomal protein S35, mitochon...
MRPS35
162Annotation score:
F5H612F5H612_HUMAN
28S ribosomal protein S35, mitochon...
MRPS35
41Annotation score:
H0YFD1H0YFD1_HUMAN
28S ribosomal protein S35, mitochon...
MRPS35
38Annotation score:

Sequence cautioni

The sequence AAG14958 differs from that shown. Reason: Frameshift at position 97.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0520516L → I. Corresponds to variant dbSNP:rs35475802Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054096176 – 194KLSSL…LIKLV → PFKEAELRLCSVSTNSVIP in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_054097195 – 323Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182422 mRNA Translation: AAG14958.1 Frameshift.
AK075378 mRNA Translation: BAC11579.1
AK075515 mRNA Translation: BAC11664.1
BC015862 mRNA Translation: AAH15862.2
BC017086 mRNA Translation: AAH17086.1
BC028346 mRNA Translation: AAH28346.2
BC063515 mRNA Translation: AAH63515.1
BC109372 mRNA Translation: AAI09373.1
AL512733 mRNA Translation: CAC21665.1
AF068296 mRNA Translation: AAF65185.1
CCDSiCCDS53769.1 [P82673-2]
CCDS8714.1 [P82673-1]
RefSeqiNP_001177793.1, NM_001190864.1 [P82673-2]
NP_068593.2, NM_021821.3 [P82673-1]
UniGeneiHs.714076

Genome annotation databases

EnsembliENST00000081029; ENSP00000081029; ENSG00000061794 [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794 [P82673-2]
GeneIDi60488
KEGGihsa:60488
UCSCiuc001rih.4 human [P82673-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182422 mRNA Translation: AAG14958.1 Frameshift.
AK075378 mRNA Translation: BAC11579.1
AK075515 mRNA Translation: BAC11664.1
BC015862 mRNA Translation: AAH15862.2
BC017086 mRNA Translation: AAH17086.1
BC028346 mRNA Translation: AAH28346.2
BC063515 mRNA Translation: AAH63515.1
BC109372 mRNA Translation: AAI09373.1
AL512733 mRNA Translation: CAC21665.1
AF068296 mRNA Translation: AAF65185.1
CCDSiCCDS53769.1 [P82673-2]
CCDS8714.1 [P82673-1]
RefSeqiNP_001177793.1, NM_001190864.1 [P82673-2]
NP_068593.2, NM_021821.3 [P82673-1]
UniGeneiHs.714076

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A11-323[»]
ProteinModelPortaliP82673
SMRiP82673
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121919, 102 interactors
CORUMiP82673
IntActiP82673, 36 interactors
MINTiP82673
STRINGi9606.ENSP00000081029

PTM databases

iPTMnetiP82673
PhosphoSitePlusiP82673

Polymorphism and mutation databases

BioMutaiMRPS35
DMDMi74708095

Proteomic databases

EPDiP82673
MaxQBiP82673
PaxDbiP82673
PeptideAtlasiP82673
PRIDEiP82673
ProteomicsDBi57712
57713 [P82673-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000081029; ENSP00000081029; ENSG00000061794 [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794 [P82673-2]
GeneIDi60488
KEGGihsa:60488
UCSCiuc001rih.4 human [P82673-1]

Organism-specific databases

CTDi60488
EuPathDBiHostDB:ENSG00000061794.12
GeneCardsiMRPS35
HGNCiHGNC:16635 MRPS35
HPAiHPA038513
MIMi611995 gene
neXtProtiNX_P82673
OpenTargetsiENSG00000061794
PharmGKBiPA31022
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3933 Eukaryota
ENOG410ZX0Y LUCA
GeneTreeiENSGT00390000003443
HOVERGENiHBG082941
InParanoidiP82673
KOiK17413
OMAiYANAELM
OrthoDBiEOG091G0ELS
PhylomeDBiP82673
TreeFamiTF318686

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS35 human
GeneWikiiMRPS35
GenomeRNAii60488
PROiPR:P82673
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000061794 Expressed in 226 organ(s), highest expression level in corpus callosum
CleanExiHS_MRPS28
HS_MRPS35
ExpressionAtlasiP82673 baseline and differential
GenevisibleiP82673 HS

Family and domain databases

InterProiView protein in InterPro
IPR039848 Ribosomal_S24/S35
IPR019349 Ribosomal_S24/S35_mit
PANTHERiPTHR13490 PTHR13490, 1 hit
PfamiView protein in Pfam
PF10213 MRP-S28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT35_HUMAN
AccessioniPrimary (citable) accession number: P82673
Secondary accession number(s): Q32LZ1
, Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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