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Protein

Alpha-elapitoxin-Oh2b

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (By similarity). Recombinant LNTX1 leads to a functional block of the muscle-type acetylcholine receptors. Has a cytotoxic activity. This neurotoxin is lethal (PubMed:16689684).By similarity1 Publication

Miscellaneous

OH-6A and OH-6B are disulfide isomers which arise from cis-trans isomerization of the Cys-47-Cys-51 disulfide bond. They differ in the retention time in reversed-phase column and the conformation.

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-elapitoxin-Oh2b
Short name:
Alpha-EPTX-Oh2b
Alternative name(s):
Alpha-neurotoxin
LNTX3
Long neurotoxin OH-6A/OH-6B
OH-3
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.41 mg/kg by intravenous injection into mice.
LD50 is 100 µg/kg by intraperitoneal injection into mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000009356122 – 91Alpha-elapitoxin-Oh2bAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 41By similarity
Disulfide bondi34 ↔ 62By similarity
Disulfide bondi47 ↔ 51By similarity
Disulfide bondi66 ↔ 77By similarity
Disulfide bondi78 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiP82662

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliP82662
SMRiP82662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTLVV MTIVCLDLGY TLICFISSHD SVTCAPGENV CFLKSWCDAW
60 70 80 90
CGSRGKKLSF GCAATCPKVN PGIDIECCST DNCNPHPKLR P
Length:91
Mass (Da):9,857
Last modified:January 15, 2008 - v2
Checksum:i756AFC1424E97250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596926 mRNA Translation: AAT97248.1
DQ273568 mRNA Translation: ABB83622.1
PIRiJG0189

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596926 mRNA Translation: AAT97248.1
DQ273568 mRNA Translation: ABB83622.1
PIRiJG0189

3D structure databases

ProteinModelPortaliP82662
SMRiP82662
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

TopDownProteomicsiP82662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3L26_OPHHA
AccessioniPrimary (citable) accession number: P82662
Secondary accession number(s): Q53B60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 15, 2008
Last modified: November 22, 2017
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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