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UniProtKB - P82451 (ABCC9_RABIT)
Protein
ATP-binding cassette sub-family C member 9
Gene
ABCC9
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 705 – 712 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1346 – 1353 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- sulfonylurea receptor activity Source: InterPro
GO - Biological processi
- potassium ion transport Source: InterPro
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family C member 9Alternative name(s): Sulfonylurea receptor 2 |
Gene namesi | Name:ABCC9 Synonyms:SUR2 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 52 – 72 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 94 – 101 | ExtracellularSequence analysis | 8 | |
Transmembranei | 102 – 122 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 123 – 132 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 133 – 153 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 154 – 167 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 168 – 188 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 189 – 301 | CytoplasmicSequence analysisAdd BLAST | 113 | |
Transmembranei | 302 – 322 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 323 – 350 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 351 – 371 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 372 – 423 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 424 – 444 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 445 – 455 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 456 – 476 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 477 – 531 | CytoplasmicSequence analysisAdd BLAST | 55 | |
Transmembranei | 532 – 552 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 553 – 571 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 572 – 592 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 593 – 990 | CytoplasmicSequence analysisAdd BLAST | 398 | |
Transmembranei | 991 – 1011 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1012 – 1034 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 1035 – 1055 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1056 – 1127 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 1128 – 1148 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1149 – 1245 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 1246 – 1266 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1267 – 1549 | CytoplasmicSequence analysisAdd BLAST | 283 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093404 | 1 – 1549 | ATP-binding cassette sub-family C member 9Add BLAST | 1549 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 326 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1025 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Interacts with KCNJ11.
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000006942 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 297 – 597 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 301 | |
Domaini | 665 – 912 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 248 | |
Domaini | 994 – 1274 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 1312 – 1546 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 944 – 967 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 950 – 966 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | P82451 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P82451-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSFCGNNI SSYNIYDGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSRRESR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQSGW GVSDLRFCIT GIMVILNGLL MAVEINVIRI RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHK KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKDAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNETQN GTNNTTGISE ILSSKEFLEN
360 370 380 390 400
AYVLAVLLFL ALILQRTFLQ ASYYVTIETG INLRGALLAM IYNKILRLST
410 420 430 440 450
SNLSMGEMTL GQINNLVAIE TNQLMWFLFL CPNLWAMPVQ IIMGVILLYN
460 470 480 490 500
LLGSSALVGA AVIVLLAPMQ YFIATKLAEA QKSTLDYSTE RLKKTNEILK
510 520 530 540 550
GIKLLKLYAW EHIFCKSVEE TRVKELSSLK AFALYTSLSI FMNAAIPIAA
560 570 580 590 600
VLATFVTHAY ASGNNLQPAE AFASLSLFHI LVTPLFLLST VVRFAVKAII
610 620 630 640 650
SVQKLNEFLL SDEIGDDSWR TGEASLPFES CKKHTGVQPK TINRKQPGRY
660 670 680 690 700
HLDSYEQSTR RLRPMETEDI AIKVTNGCFS WGSGAATLSN IDIRIPTGQL
710 720 730 740 750
TMIVGQVGCG KSSLLLAILG EMQTLDGKVH WSNVNESEPS FEATRSRNRY
760 770 780 790 800
SVAYAAQKPW LLNATVEENI TFGSPFNKQR YKAVTDACSL QPDIDLLPFG
810 820 830 840 850
DQTEIGERGI NLSGGQTERI CVARALYQNT NIVFLDDPFS ALDIHLSDHL
860 870 880 890 900
MQEGILKFLQ DDKRTLVLVT HKLQYLTHAD WIIAMKDGSV LREGTLKDIQ
910 920 930 940 950
TKDVELYEHW KTLMNRQDQE LEKDMEADQT TLERKTLRRA MYSREAKAQM
960 970 980 990 1000
EDEDEEEEEE EDEDDNMSTV MRLRTKMPWK TCWRYLTSGG FFLLFLMIFS
1010 1020 1030 1040 1050
KLLKHSVIVA IDYWLATWTS EYSINNTGKA DQTYYVAGFS ILCGAGIFLC
1060 1070 1080 1090 1100
LVTSLTVEWM GLTAAKNLHH NLLNKIILGP IRFFDTTPLG LILNRFSADT
1110 1120 1130 1140 1150
NIIDQHIPPT LESLTRSTLL CLSAIGMISY ATPVFLVALV PLGVAFYFIQ
1160 1170 1180 1190 1200
KYFRVASKDL QELDDSTQLP LLCHFSETAE GLTTIRAFRH EARFKQRMLE
1210 1220 1230 1240 1250
LTDTNNIAYL FLSAANRWLE VRTDYLGACI VLTASIASIS GSSNSGLVGL
1260 1270 1280 1290 1300
GLLYALTITN YLNWVVRNLA DLEVQMGAVK KVNSFLTMES ENYEGTMDPS
1310 1320 1330 1340 1350
QVPEHWPQEG EIKIHDLCVR YENNLKPVLK HVKAYIKPGQ KVGICGRTGS
1360 1370 1380 1390 1400
GKSSLSLAFF RMVDIFDGKI VIDGIDISKL PLHTLRSRLS IILQDPILFS
1410 1420 1430 1440 1450
GSIRFNLDPE CKCTDDRLWE ALEIAQLKNM VKSLSGGLDA VVTEGGENFS
1460 1470 1480 1490 1500
VGQRQLFCLA RAFVRKSSIL IMDEATASID MATENILQKV VMTAFADRTV
1510 1520 1530 1540
VTIAHRVSSI VDADLVLVFS EGILVECDTG PNLLTHKNGL FSTLVMTNK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087468 mRNA Translation: AAD52090.1 AF417510 mRNA Translation: AAL07505.1 |
RefSeqi | NP_001075513.1, NM_001082044.1 |
Genome annotation databases
GeneIDi | 100008700 |
KEGGi | ocu:100008700 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087468 mRNA Translation: AAD52090.1 AF417510 mRNA Translation: AAL07505.1 |
RefSeqi | NP_001075513.1, NM_001082044.1 |
3D structure databases
SMRi | P82451 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000006942 |
Genome annotation databases
GeneIDi | 100008700 |
KEGGi | ocu:100008700 |
Organism-specific databases
CTDi | 10060 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
InParanoidi | P82451 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCC9_RABIT | |
Accessioni | P82451Primary (citable) accession number: P82451 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | June 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families