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Protein

Aurein-1.2

Gene
N/A
Organism
Litoria raniformis (Southern bell frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Aurein-1.2
OrganismiLitoria raniformis (Southern bell frog)
Taxonomic identifieri116057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePelodryadinaeLitoria

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000437191 – 13Aurein-1.2Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Phenylalanine amide1 Publication1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the skin dorsal glands.

Structurei

Secondary structure

113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP82387
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82387

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR013157 Aurein_antimicrobial_peptide
PfamiView protein in Pfam
PF08256 Antimicrobial20, 1 hit

Sequencei

Sequence statusi: Complete.

Length:13
Mass (Da):1,481
Last modified:May 1, 2000 - v1
Checksum:i1EACB99DFBC83330
GO

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VM5NMR-A1-13[»]
SMRiP82387
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP82387

Family and domain databases

InterProiView protein in InterPro
IPR013157 Aurein_antimicrobial_peptide
PfamiView protein in Pfam
PF08256 Antimicrobial20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAUR12_LITRA
AccessioniPrimary (citable) accession number: P82387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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