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Protein

Gamma-sarcoglycan

Gene

Sgcg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

  • heart contraction Source: GO_Central
  • membrane organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-sarcoglycan
Short name:
Gamma-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name:
35DAG
Gene namesi
Name:Sgcg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1346524 Sgcg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 291ExtracellularSequence analysisAdd BLAST233

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752501 – 291Gamma-sarcoglycanAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 290Sequence analysis
Disulfide bondi267 ↔ 283Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP82348
PaxDbiP82348
PRIDEiP82348

PTM databases

iPTMnetiP82348
PhosphoSitePlusiP82348

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiENSMUSG00000035296 Expressed in 138 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiP82348 baseline and differential
GenevisibleiP82348 MM

Interactioni

Subunit structurei

Interacts with the syntrophin SNTA1 and FLNC. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.2 Publications

Protein-protein interaction databases

BioGridi204866, 3 interactors
CORUMiP82348
STRINGi10090.ENSMUSP00000077106

Structurei

3D structure databases

ProteinModelPortaliP82348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiP82348
KOiK12564
OMAiDPFQDLR
OrthoDBiEOG091G11VY
PhylomeDBiP82348
TreeFamiTF313538

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027660 SGCG
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF4 PTHR12939:SF4, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit

Sequencei

Sequence statusi: Complete.

P82348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVREQYTTVT EGTHIERPEN QHIYKIGIYG WRKRCLYLFV LLLLAILVVN
60 70 80 90 100
LALTIWILKV MWFSPIGMGH LHVTADGLRL EGESEFLFPL YAKEIRSRVD
110 120 130 140 150
SSLLLQSTQN VTVSARNSEG EVTGRVKVGA QMVEVQSQHF QINSEDGKPL
160 170 180 190 200
FSAEEQDVVV GTGRLRVTGP EGALFEHSVE TPLVRADPFQ DLRLESPTRS
210 220 230 240 250
LSMDAPRGVH VKANAGKLEA LSQMDIILQS SEGVLVLDAE TVGLTKLKQG
260 270 280 290
TQGPAGSSNG FYEICACPDG KLYLSMAGEV TTCEEHSHVC L
Length:291
Mass (Da):32,082
Last modified:January 23, 2007 - v2
Checksum:iD61C53F08F241140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024922 mRNA Translation: BAA83493.1
CCDSiCCDS27181.1
RefSeqiNP_036022.1, NM_011892.3
XP_006519075.1, XM_006519012.2
UniGeneiMm.489356
Mm.72173

Genome annotation databases

EnsembliENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296
ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296
GeneIDi24053
KEGGimmu:24053
UCSCiuc007ufs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024922 mRNA Translation: BAA83493.1
CCDSiCCDS27181.1
RefSeqiNP_036022.1, NM_011892.3
XP_006519075.1, XM_006519012.2
UniGeneiMm.489356
Mm.72173

3D structure databases

ProteinModelPortaliP82348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204866, 3 interactors
CORUMiP82348
STRINGi10090.ENSMUSP00000077106

PTM databases

iPTMnetiP82348
PhosphoSitePlusiP82348

Proteomic databases

EPDiP82348
PaxDbiP82348
PRIDEiP82348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296
ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296
GeneIDi24053
KEGGimmu:24053
UCSCiuc007ufs.1 mouse

Organism-specific databases

CTDi6445
MGIiMGI:1346524 Sgcg

Phylogenomic databases

eggNOGiKOG3950 Eukaryota
ENOG4111GCH LUCA
GeneTreeiENSGT00390000017950
HOGENOMiHOG000007853
HOVERGENiHBG008669
InParanoidiP82348
KOiK12564
OMAiDPFQDLR
OrthoDBiEOG091G11VY
PhylomeDBiP82348
TreeFamiTF313538

Miscellaneous databases

PROiPR:P82348
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035296 Expressed in 138 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiP82348 baseline and differential
GenevisibleiP82348 MM

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR039972 Sarcoglycan_gamma/delta/zeta
IPR027660 SGCG
PANTHERiPTHR12939 PTHR12939, 1 hit
PTHR12939:SF4 PTHR12939:SF4, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGCG_MOUSE
AccessioniPrimary (citable) accession number: P82348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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