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Protein

N-acylglucosamine 2-epimerase

Gene

Renbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.1 Publication

Caution

It is uncertain whether Met-1, Met-2, Met-8 or Met-12 is the initiator.Curated

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.1 Publication

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

GO - Biological processi

  • N-acetylglucosamine metabolic process Source: MGI
  • N-acetylmannosamine metabolic process Source: MGI
  • N-acetylneuraminate catabolic process Source: UniProtKB
  • negative regulation of catalytic activity Source: MGI
  • negative regulation of endopeptidase activity Source: MGI

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-MMU-446210 Synthesis of UDP-N-acetyl-glucosamine
UniPathwayi
UPA00629

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:Renbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:105940 Renbp

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089501 – 430N-acylglucosamine 2-epimeraseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei429PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP82343
PaxDbiP82343
PeptideAtlasiP82343
PRIDEiP82343

PTM databases

iPTMnetiP82343
PhosphoSitePlusiP82343

Expressioni

Gene expression databases

BgeeiENSMUSG00000031387 Expressed in 219 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_RENBP
ExpressionAtlasiP82343 baseline and differential
GenevisibleiP82343 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112277

Structurei

3D structure databases

ProteinModelPortaliP82343
SMRiP82343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 217Leucine-zipperAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08 Eukaryota
COG2942 LUCA
GeneTreeiENSGT00390000013740
HOGENOMiHOG000252296
HOVERGENiHBG054048
InParanoidiP82343
KOiK01787
OMAiPMMLLNL
OrthoDBiEOG091G0EO8
PhylomeDBiP82343
TreeFamiTF329027

Family and domain databases

CDDicd00249 AGE, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR034116 AGE_dom
SUPFAMiSSF48208 SSF48208, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P82343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDLGLLMLQ DMEKERETLQ VWKKRVEQEL DRVIAFWMEH SHDQEHGGFF
60 70 80 90 100
TCLGRDGKVY DHLKYVWLQG RQVWMYCRLY RSFERFRRVE LLDAARAGGE
110 120 130 140 150
FLLRYARVAP PGKKCAFVLT RDGRPVKVQR TIFSECFYTM AMNELWKVTG
160 170 180 190 200
EVRYQSEAIE MMDQIIHWVR EDPAGLGRPQ LSGALATEPM AVPMMLLSLV
210 220 230 240 250
EQLGEEDEEL TNMYAELGDW CVHRILQHVQ RDGQVVLENV SEDGKELPGC
260 270 280 290 300
LGRHQNPGHT LEAGWFLLQY ALRKGDPKLR MHIIDKFLLL PFHSGWDPEH
310 320 330 340 350
GGLFYFQDAD GLCPTQLEWN MKLWWPHSEA MIAFLMGYSD SGDPALLHLF
360 370 380 390 400
YKVAEYTFRQ FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM
410 420 430
CEQILGALLQ RLEPAPLDSS PAVSTHEGSK
Length:430
Mass (Da):49,771
Last modified:April 20, 2010 - v3
Checksum:iAC02782E9860BC77
GO
Isoform 2 (identifier: P82343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-72: Missing.

Show »
Length:416
Mass (Da):47,984
Checksum:i91295AA582837718
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHA2D6RHA2_MOUSE
N-acylglucosamine 2-epimerase
Renbp
419Annotation score:
G3XA46G3XA46_MOUSE
N-acylglucosamine 2-epimerase
Renbp
48Annotation score:

Sequence cautioni

The sequence AAH14821 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO66340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB29288 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177 – 178GR → AV in BAB29288 (PubMed:16141072).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03902459 – 72Missing in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133093 Genomic DNA No translation available.
AY183138 mRNA Translation: AAO66340.1 Different initiation.
AK014347 mRNA Translation: BAB29288.1 Different initiation.
AK146652 mRNA Translation: BAE27332.1
AK167648 mRNA Translation: BAE39699.1
AL672002 Genomic DNA Translation: CAM18723.1
AL672002 Genomic DNA Translation: CAM18724.1
CH466650 Genomic DNA Translation: EDL29852.1
CH466650 Genomic DNA Translation: EDL29854.1
BC014821 mRNA Translation: AAH14821.1 Different initiation.
CCDSiCCDS41015.2 [P82343-1]
CCDS57763.1 [P82343-2]
RefSeqiNP_001158176.1, NM_001164704.1 [P82343-2]
NP_075621.3, NM_023132.3 [P82343-1]
UniGeneiMm.236969

Genome annotation databases

EnsembliENSMUST00000114379; ENSMUSP00000110020; ENSMUSG00000031387 [P82343-2]
ENSMUST00000116578; ENSMUSP00000112277; ENSMUSG00000031387 [P82343-1]
GeneIDi19703
KEGGimmu:19703
UCSCiuc009tnj.2 mouse [P82343-1]
uc009tnk.2 mouse [P82343-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRENBP_MOUSE
AccessioniPrimary (citable) accession number: P82343
Secondary accession number(s): Q3TIZ6
, Q3UJ23, Q80Z67, Q91WI9, Q9CXI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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