UniProtKB - P82343 (RENBP_MOUSE)
Protein
N-acylglucosamine 2-epimerase
Gene
Renbp
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.1 Publication
Caution
It is uncertain whether Met-1, Met-2, Met-8 or Met-12 is the initiator.Curated
Catalytic activityi
- EC:5.1.3.81 Publication
: N-acetylneuraminate degradation Pathwayi
This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.
GO - Molecular functioni
- ATP binding Source: MGI
- enzyme inhibitor activity Source: MGI
- identical protein binding Source: MGI
- N-acylglucosamine 2-epimerase activity Source: UniProtKB
- peptidase inhibitor activity Source: GO_Central
- purine nucleotide binding Source: MGI
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- N-acetylglucosamine metabolic process Source: MGI
- N-acetylmannosamine metabolic process Source: MGI
- N-acetylneuraminate catabolic process Source: UniProtKB
- negative regulation of catalytic activity Source: MGI
- negative regulation of endopeptidase activity Source: MGI
Keywordsi
Molecular function | Isomerase |
Enzyme and pathway databases
Reactomei | R-MMU-446210, Synthesis of UDP-N-acetyl-glucosamine |
UniPathwayi | UPA00629 |
Names & Taxonomyi
Protein namesi | Recommended name: N-acylglucosamine 2-epimerase (EC:5.1.3.8)Short name: AGE Alternative name(s): GlcNAc 2-epimerase N-acetyl-D-glucosamine 2-epimerase Renin-binding protein Short name: RnBP |
Gene namesi | Name:Renbp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105940, Renbp |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208950 | 1 – 430 | N-acylglucosamine 2-epimeraseAdd BLAST | 430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 429 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P82343 |
MaxQBi | P82343 |
PaxDbi | P82343 |
PeptideAtlasi | P82343 |
PRIDEi | P82343 |
PTM databases
iPTMneti | P82343 |
PhosphoSitePlusi | P82343 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031387, Expressed in adult mammalian kidney and 238 other tissues |
ExpressionAtlasi | P82343, baseline and differential |
Genevisiblei | P82343, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112277 |
Miscellaneous databases
RNActi | P82343, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 196 – 217 | Leucine-zipperAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the N-acylglucosamine 2-epimerase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSDA, Eukaryota |
GeneTreei | ENSGT00390000013740 |
InParanoidi | P82343 |
OrthoDBi | 931816at2759 |
PhylomeDBi | P82343 |
TreeFami | TF329027 |
Family and domain databases
CDDi | cd00249, AGE, 1 hit |
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR034116, AGE_dom |
SUPFAMi | SSF48208, SSF48208, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P82343-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMDLGLLMLQ DMEKERETLQ VWKKRVEQEL DRVIAFWMEH SHDQEHGGFF
60 70 80 90 100
TCLGRDGKVY DHLKYVWLQG RQVWMYCRLY RSFERFRRVE LLDAARAGGE
110 120 130 140 150
FLLRYARVAP PGKKCAFVLT RDGRPVKVQR TIFSECFYTM AMNELWKVTG
160 170 180 190 200
EVRYQSEAIE MMDQIIHWVR EDPAGLGRPQ LSGALATEPM AVPMMLLSLV
210 220 230 240 250
EQLGEEDEEL TNMYAELGDW CVHRILQHVQ RDGQVVLENV SEDGKELPGC
260 270 280 290 300
LGRHQNPGHT LEAGWFLLQY ALRKGDPKLR MHIIDKFLLL PFHSGWDPEH
310 320 330 340 350
GGLFYFQDAD GLCPTQLEWN MKLWWPHSEA MIAFLMGYSD SGDPALLHLF
360 370 380 390 400
YKVAEYTFRQ FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM
410 420 430
CEQILGALLQ RLEPAPLDSS PAVSTHEGSK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RHA2 | D6RHA2_MOUSE | GlcNAc 2-epimerase | Renbp | 419 | Annotation score: | ||
G3XA46 | G3XA46_MOUSE | N-acylglucosamine 2-epimerase | Renbp | 48 | Annotation score: |
Sequence cautioni
The sequence AAH14821 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO66340 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB29288 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 – 178 | GR → AV in BAB29288 (PubMed:16141072).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039024 | 59 – 72 | Missing in isoform 2. 2 PublicationsAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133093 Genomic DNA No translation available. AY183138 mRNA Translation: AAO66340.1 Different initiation. AK014347 mRNA Translation: BAB29288.1 Different initiation. AK146652 mRNA Translation: BAE27332.1 AK167648 mRNA Translation: BAE39699.1 AL672002 Genomic DNA No translation available. CH466650 Genomic DNA Translation: EDL29852.1 CH466650 Genomic DNA Translation: EDL29854.1 BC014821 mRNA Translation: AAH14821.1 Different initiation. |
CCDSi | CCDS41015.2 [P82343-1] CCDS57763.1 [P82343-2] |
RefSeqi | NP_001158176.1, NM_001164704.1 [P82343-2] NP_075621.3, NM_023132.3 [P82343-1] |
Genome annotation databases
Ensembli | ENSMUST00000114379; ENSMUSP00000110020; ENSMUSG00000031387 [P82343-2] ENSMUST00000116578; ENSMUSP00000112277; ENSMUSG00000031387 [P82343-1] |
GeneIDi | 19703 |
KEGGi | mmu:19703 |
UCSCi | uc009tnj.2, mouse [P82343-1] uc009tnk.2, mouse [P82343-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133093 Genomic DNA No translation available. AY183138 mRNA Translation: AAO66340.1 Different initiation. AK014347 mRNA Translation: BAB29288.1 Different initiation. AK146652 mRNA Translation: BAE27332.1 AK167648 mRNA Translation: BAE39699.1 AL672002 Genomic DNA No translation available. CH466650 Genomic DNA Translation: EDL29852.1 CH466650 Genomic DNA Translation: EDL29854.1 BC014821 mRNA Translation: AAH14821.1 Different initiation. |
CCDSi | CCDS41015.2 [P82343-1] CCDS57763.1 [P82343-2] |
RefSeqi | NP_001158176.1, NM_001164704.1 [P82343-2] NP_075621.3, NM_023132.3 [P82343-1] |
3D structure databases
SMRi | P82343 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112277 |
PTM databases
iPTMneti | P82343 |
PhosphoSitePlusi | P82343 |
Proteomic databases
jPOSTi | P82343 |
MaxQBi | P82343 |
PaxDbi | P82343 |
PeptideAtlasi | P82343 |
PRIDEi | P82343 |
Protocols and materials databases
Antibodypediai | 413, 115 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000114379; ENSMUSP00000110020; ENSMUSG00000031387 [P82343-2] ENSMUST00000116578; ENSMUSP00000112277; ENSMUSG00000031387 [P82343-1] |
GeneIDi | 19703 |
KEGGi | mmu:19703 |
UCSCi | uc009tnj.2, mouse [P82343-1] uc009tnk.2, mouse [P82343-2] |
Organism-specific databases
CTDi | 5973 |
MGIi | MGI:105940, Renbp |
Phylogenomic databases
eggNOGi | ENOG502QSDA, Eukaryota |
GeneTreei | ENSGT00390000013740 |
InParanoidi | P82343 |
OrthoDBi | 931816at2759 |
PhylomeDBi | P82343 |
TreeFami | TF329027 |
Enzyme and pathway databases
UniPathwayi | UPA00629 |
Reactomei | R-MMU-446210, Synthesis of UDP-N-acetyl-glucosamine |
Miscellaneous databases
BioGRID-ORCSi | 19703, 0 hits in 17 CRISPR screens |
ChiTaRSi | Renbp, mouse |
PROi | PR:P82343 |
RNActi | P82343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031387, Expressed in adult mammalian kidney and 238 other tissues |
ExpressionAtlasi | P82343, baseline and differential |
Genevisiblei | P82343, MM |
Family and domain databases
CDDi | cd00249, AGE, 1 hit |
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR034116, AGE_dom |
SUPFAMi | SSF48208, SSF48208, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RENBP_MOUSE | |
Accessioni | P82343Primary (citable) accession number: P82343 Secondary accession number(s): Q3TIZ6 Q9CXI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families