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Protein

Transforming growth factor-beta-induced protein ig-h3

Gene

Tgfbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).By similarity1 Publication

GO - Molecular functioni

  • collagen binding Source: MGI
  • extracellular matrix binding Source: MGI
  • integrin binding Source: InterPro

GO - Biological processi

  • angiogenesis Source: Ensembl
  • cell adhesion Source: MGI
  • cell proliferation Source: InterPro
  • chondrocyte differentiation Source: Ensembl
  • extracellular matrix organization Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor-beta-induced protein ig-h3
Short name:
Beta ig-h3
Gene namesi
Name:Tgfbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99959 Tgfbi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000004198024 – 683Transforming growth factor-beta-induced protein ig-h3Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Disulfide bondi49 ↔ 85By similarity
Modified residuei65S-cysteinyl cysteineBy similarity1
Disulfide bondi74 ↔ 339By similarity
Disulfide bondi84 ↔ 97By similarity
Disulfide bondi214 ↔ 317By similarity
Disulfide bondi473 ↔ 478By similarity

Post-translational modificationi

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.By similarity
The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.By similarity

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP82198
PaxDbiP82198
PRIDEiP82198

PTM databases

iPTMnetiP82198
PhosphoSitePlusiP82198

Expressioni

Tissue specificityi

Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).1 Publication

Developmental stagei

Expressed in the embryo at 12 dpc (PubMed:8024701).1 Publication

Gene expression databases

BgeeiENSMUSG00000035493
CleanExiMM_TGFBI
ExpressionAtlasiP82198 baseline and differential
GenevisibleiP82198 MM

Interactioni

Subunit structurei

Binds to type I, II, and IV collagens.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204162, 1 interactor
IntActiP82198, 1 interactor
MINTiP82198
STRINGi10090.ENSMUSP00000037719

Structurei

3D structure databases

ProteinModelPortaliP82198
SMRiP82198
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 99EMIPROSITE-ProRule annotationAdd BLAST55
Domaini103 – 236FAS1 1PROSITE-ProRule annotationAdd BLAST134
Domaini240 – 371FAS1 2PROSITE-ProRule annotationAdd BLAST132
Domaini375 – 498FAS1 3PROSITE-ProRule annotationAdd BLAST124
Domaini502 – 632FAS1 4PROSITE-ProRule annotationAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi642 – 644Cell attachment siteSequence analysis3

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1437 Eukaryota
COG2335 LUCA
GeneTreeiENSGT00530000063860
HOGENOMiHOG000220865
HOVERGENiHBG000715
InParanoidiP82198
KOiK19519
OMAiKHGMALT
OrthoDBiEOG091G020T
PhylomeDBiP82198
TreeFamiTF316269

Family and domain databases

Gene3Di2.30.180.10, 4 hits
InterProiView protein in InterPro
IPR011489 EMI_domain
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR032954 TGFBI
IPR016666 TGFBI/POSTN
PANTHERiPTHR10900:SF82 PTHR10900:SF82, 1 hit
PfamiView protein in Pfam
PF02469 Fasciclin, 4 hits
PIRSFiPIRSF016553 BIGH3_OSF2, 1 hit
SMARTiView protein in SMART
SM00554 FAS1, 4 hits
SUPFAMiSSF82153 SSF82153, 4 hits
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit
PS50213 FAS1, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA
60 70 80 90 100
VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA
110 120 130 140 150
LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS
160 170 180 190 200
LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI
210 220 230 240 250
QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE
260 270 280 290 300
DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP
310 320 330 340 350
EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA
360 370 380 390 400
VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL
410 420 430 440 450
DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY
460 470 480 490 500
SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP
510 520 530 540 550
PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM
560 570 580 590 600
PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS
610 620 630 640 650
SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA
660 670 680
LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH
Length:683
Mass (Da):74,597
Last modified:May 1, 2000 - v1
Checksum:i2B6E9DBB9C50F52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19932 mRNA Translation: AAC37658.1
AK084431 mRNA Translation: BAC39181.1
AK142323 mRNA Translation: BAE25032.1
AK151680 mRNA Translation: BAE30605.1
AK152365 mRNA Translation: BAE31155.1
AK155572 mRNA Translation: BAE33330.1
AK155828 mRNA Translation: BAE33452.1
AK170495 mRNA Translation: BAE41834.1
CCDSiCCDS36680.1
RefSeqiNP_033395.1, NM_009369.4
UniGeneiMm.14455

Genome annotation databases

EnsembliENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493
GeneIDi21810
KEGGimmu:21810
UCSCiuc011zae.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBGH3_MOUSE
AccessioniPrimary (citable) accession number: P82198
Secondary accession number(s): Q3U9R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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