Tgfbi

Functionⁱ

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

collagen binding Source: MGI
extracellular matrix binding
Source: MGI
Inferred from direct assayⁱ
- 18757743
integrin binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
cell adhesion
Source: MGI
Inferred from direct assayⁱ
- 12963107
cell proliferation Source: InterPro
chondrocyte differentiation Source: Ensembl
extracellular matrix organization
Source: MGI
Inferred from direct assayⁱ
- 18757743

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transforming growth factor-beta-induced protein ig-h3 Short name: Beta ig-h3
Gene namesⁱ	Name:Tgfbi
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:99959 Tgfbi

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	By similarityAdd BLAST		23
ChainⁱPRO_0000041980	24 – 683	Transforming growth factor-beta-induced protein ig-h3Add BLAST		660

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	37	PhosphoserineBy similarity	1
Disulfide bondⁱ	49 ↔ 85	By similarity
Modified residueⁱ	65	S-cysteinyl cysteineBy similarity	1
Disulfide bondⁱ	74 ↔ 339	By similarity
Disulfide bondⁱ	84 ↔ 97	By similarity
Disulfide bondⁱ	214 ↔ 317	By similarity
Disulfide bondⁱ	473 ↔ 478	By similarity

Post-translational modificationⁱ

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.By similarity

The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.By similarity

Keywords - PTMⁱ

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P82198
PaxDbⁱ	P82198
PRIDEⁱ	P82198

PTM databases

iPTMnetⁱ	P82198
PhosphoSitePlusⁱ	P82198

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).1 Publication

Developmental stageⁱ

Expressed in the embryo at 12 dpc (PubMed:8024701).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000035493 Expressed in 400 organ(s), highest expression level in cornea
CleanExⁱ	MM_TGFBI
ExpressionAtlasⁱ	P82198 baseline and differential
Genevisibleⁱ	P82198 MM

Interactionⁱ

Subunit structureⁱ

Binds to type I, II, and IV collagens.By similarity

GO - Molecular functionⁱ

integrin binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204162, 1 interactor
IntActⁱ	P82198, 1 interactor
Molecular INTeraction database More...MINTⁱ	P82198
STRINGⁱ	10090.ENSMUSP00000037719

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P82198
SMRⁱ	P82198
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 99	EMIPROSITE-ProRule annotationAdd BLAST	55
Domainⁱ	103 – 236	FAS1 1PROSITE-ProRule annotationAdd BLAST	134
Domainⁱ	240 – 371	FAS1 2PROSITE-ProRule annotationAdd BLAST	132
Domainⁱ	375 – 498	FAS1 3PROSITE-ProRule annotationAdd BLAST	124
Domainⁱ	502 – 632	FAS1 4PROSITE-ProRule annotationAdd BLAST	131

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	642 – 644	Cell attachment siteSequence analysis		3

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG1437 Eukaryota COG2335 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063860
HOGENOMⁱ	HOG000220865
HOVERGENⁱ	HBG000715
InParanoidⁱ	P82198
KEGG Orthology (KO) More...KOⁱ	K19519
OMAⁱ	KHGMALT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G020T
PhylomeDBⁱ	P82198
TreeFamⁱ	TF316269

Family and domain databases

Gene3Dⁱ	2.30.180.10, 4 hits
InterProⁱ	View protein in InterPro IPR011489 EMI_domain IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR032954 TGFBI IPR016666 TGFBI/POSTN
PANTHERⁱ	PTHR10900:SF82 PTHR10900:SF82, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02469 Fasciclin, 4 hits
PIRSFⁱ	PIRSF016553 BIGH3_OSF2, 1 hit
SMARTⁱ	View protein in SMART SM00554 FAS1, 4 hits
SUPFAMⁱ	SSF82153 SSF82153, 4 hits
PROSITEⁱ	View protein in PROSITE PS51041 EMI, 1 hit PS50213 FAS1, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P82198-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA 
        60         70         80         90        100
VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA 
       110        120        130        140        150
LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS 
       160        170        180        190        200
LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI 
       210        220        230        240        250
QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE 
       260        270        280        290        300
DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP 
       310        320        330        340        350
EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA 
       360        370        380        390        400
VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL 
       410        420        430        440        450
DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY 
       460        470        480        490        500
SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP 
       510        520        530        540        550
PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM 
       560        570        580        590        600
PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS 
       610        620        630        640        650
SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA 
       660        670        680 
LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH

Length:683

Mass (Da):74,597

Last modified:May 1, 2000 - v1

Checksum:ⁱ2B6E9DBB9C50F52B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q3UXJ2	Q3UXJ2_MOUSE		Transforming growth factor-beta-ind... Transforming growth factor-beta-induced protein ig-h3	Tgfbi	651	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19932 mRNA Translation: AAC37658.1 AK084431 mRNA Translation: BAC39181.1 AK142323 mRNA Translation: BAE25032.1 AK151680 mRNA Translation: BAE30605.1 AK152365 mRNA Translation: BAE31155.1 AK155572 mRNA Translation: BAE33330.1 AK155828 mRNA Translation: BAE33452.1 AK170495 mRNA Translation: BAE41834.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36680.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033395.1, NM_009369.4
UniGeneⁱ	Mm.14455

Genome annotation databases

Ensemblⁱ	ENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493
GeneIDⁱ	21810
KEGGⁱ	mmu:21810
UCSC genome browser More...UCSCⁱ	uc011zae.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P82198	Transforming growth factor, beta induced		MOUSE		683	UniRef100_P82198
Uncharacterized protein (Fragment)		MOUSE		536

Protein	Similar proteins		Species	Score	Length	Source
P82198	Transforming growth factor, beta induced		MOUSE		683	UniRef90_P82198
Transforming growth factor, beta-induced		RAT		685
transforming growth factor-beta-induced protein ig-h3		MESAU		683
UPI0004543E57		CRIGR		837
UPI0004ED167F		NANGA		683
+9

Protein	Similar proteins		Species	Score	Length	Source
P82198	Transforming growth factor-beta-induced protein ig-h3	)	HUMAN		683	UniRef50_Q15582
Transforming growth factor-beta-induced protein ig-h3		RABIT		683
Transforming growth factor-beta-induced protein ig-h3		PIG		683
Transforming growth factor-beta-induced protein ig-h3		BOVIN		683
TGFBI isoform 3		PANTR		683
+409

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19932 mRNA Translation: AAC37658.1 AK084431 mRNA Translation: BAC39181.1 AK142323 mRNA Translation: BAE25032.1 AK151680 mRNA Translation: BAE30605.1 AK152365 mRNA Translation: BAE31155.1 AK155572 mRNA Translation: BAE33330.1 AK155828 mRNA Translation: BAE33452.1 AK170495 mRNA Translation: BAE41834.1
CCDSⁱ	CCDS36680.1
RefSeqⁱ	NP_033395.1, NM_009369.4
UniGeneⁱ	Mm.14455

3D structure databases

ProteinModelPortalⁱ	P82198
SMRⁱ	P82198
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204162, 1 interactor
IntActⁱ	P82198, 1 interactor
MINTⁱ	P82198
STRINGⁱ	10090.ENSMUSP00000037719

PTM databases

iPTMnetⁱ	P82198
PhosphoSitePlusⁱ	P82198

Proteomic databases

MaxQBⁱ	P82198
PaxDbⁱ	P82198
PRIDEⁱ	P82198

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493
GeneIDⁱ	21810
KEGGⁱ	mmu:21810
UCSCⁱ	uc011zae.1 mouse

Organism-specific databases

CTDⁱ	7045
MGIⁱ	MGI:99959 Tgfbi

Phylogenomic databases

eggNOGⁱ	KOG1437 Eukaryota COG2335 LUCA
GeneTreeⁱ	ENSGT00530000063860
HOGENOMⁱ	HOG000220865
HOVERGENⁱ	HBG000715
InParanoidⁱ	P82198
KOⁱ	K19519
OMAⁱ	KHGMALT
OrthoDBⁱ	EOG091G020T
PhylomeDBⁱ	P82198
TreeFamⁱ	TF316269

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P82198
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035493 Expressed in 400 organ(s), highest expression level in cornea
CleanExⁱ	MM_TGFBI
ExpressionAtlasⁱ	P82198 baseline and differential
Genevisibleⁱ	P82198 MM

Family and domain databases

Gene3Dⁱ	2.30.180.10, 4 hits
InterProⁱ	View protein in InterPro IPR011489 EMI_domain IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR032954 TGFBI IPR016666 TGFBI/POSTN
PANTHERⁱ	PTHR10900:SF82 PTHR10900:SF82, 1 hit
Pfamⁱ	View protein in Pfam PF02469 Fasciclin, 4 hits
PIRSFⁱ	PIRSF016553 BIGH3_OSF2, 1 hit
SMARTⁱ	View protein in SMART SM00554 FAS1, 4 hits
SUPFAMⁱ	SSF82153 SSF82153, 4 hits
PROSITEⁱ	View protein in PROSITE PS51041 EMI, 1 hit PS50213 FAS1, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BGH3_MOUSE
Accessionⁱ	P82198Primary (citable) accession number: P82198 Secondary accession number(s): Q3U9R1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	May 1, 2000
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P82198 (BGH3_MOUSE)

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Transforming growth factor-beta-induced protein ig-h3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ