UniProtKB - P82198 (BGH3_MOUSE)
Protein
Transforming growth factor-beta-induced protein ig-h3
Gene
Tgfbi
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).By similarity1 Publication
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- collagen binding Source: MGI
- extracellular matrix binding Source: MGI
- integrin binding Source: InterPro
GO - Biological processi
- angiogenesis Source: Ensembl
- cell adhesion Source: MGI
- cell population proliferation Source: InterPro
- chondrocyte differentiation Source: Ensembl
- extracellular matrix organization Source: MGI
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor-beta-induced protein ig-h3Short name: Beta ig-h3 |
Gene namesi | Name:Tgfbi |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99959 Tgfbi |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
- extracellular matrix By similarity
Note: May be associated both with microfibrils and with the cell surface.By similarity
Extracellular region or secreted
- basement membrane Source: MGI
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: MGI
- extracellular space Source: MGI
Golgi apparatus
- trans-Golgi network Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000041980 | 24 – 683 | Transforming growth factor-beta-induced protein ig-h3Add BLAST | 660 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 49 ↔ 85 | By similarity | ||
Modified residuei | 65 | S-cysteinyl cysteineBy similarity | 1 | |
Disulfide bondi | 74 ↔ 339 | By similarity | ||
Disulfide bondi | 84 ↔ 97 | By similarity | ||
Disulfide bondi | 214 ↔ 317 | By similarity | ||
Disulfide bondi | 473 ↔ 478 | By similarity |
Post-translational modificationi
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.By similarity
The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.By similarity
Keywords - PTMi
Disulfide bond, Gamma-carboxyglutamic acid, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3690 |
MaxQBi | P82198 |
PaxDbi | P82198 |
PRIDEi | P82198 |
PTM databases
iPTMneti | P82198 |
PhosphoSitePlusi | P82198 |
Expressioni
Tissue specificityi
Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).1 Publication
Developmental stagei
Expressed in the embryo at 12 dpc (PubMed:8024701).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000035493 Expressed in 400 organ(s), highest expression level in cornea |
ExpressionAtlasi | P82198 baseline and differential |
Genevisiblei | P82198 MM |
Interactioni
Subunit structurei
Binds to type I, II, and IV collagens.
By similarityGO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- integrin binding Source: InterPro
Protein-protein interaction databases
BioGridi | 204162, 1 interactor |
IntActi | P82198, 1 interactor |
MINTi | P82198 |
STRINGi | 10090.ENSMUSP00000037719 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 99 | EMIPROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 103 – 236 | FAS1 1PROSITE-ProRule annotationAdd BLAST | 134 | |
Domaini | 240 – 371 | FAS1 2PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 375 – 498 | FAS1 3PROSITE-ProRule annotationAdd BLAST | 124 | |
Domaini | 502 – 632 | FAS1 4PROSITE-ProRule annotationAdd BLAST | 131 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 642 – 644 | Cell attachment siteSequence analysis | 3 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1437 Eukaryota COG2335 LUCA |
GeneTreei | ENSGT00530000063860 |
HOGENOMi | HOG000220865 |
InParanoidi | P82198 |
KOi | K19519 |
OMAi | MGNAKEL |
OrthoDBi | 926852at2759 |
PhylomeDBi | P82198 |
TreeFami | TF316269 |
Family and domain databases
Gene3Di | 2.30.180.10, 4 hits |
InterProi | View protein in InterPro IPR011489 EMI_domain IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR032954 TGFBI IPR016666 TGFBI/POSTN |
PANTHERi | PTHR10900:SF82 PTHR10900:SF82, 1 hit |
Pfami | View protein in Pfam PF02469 Fasciclin, 4 hits |
PIRSFi | PIRSF016553 BIGH3_OSF2, 1 hit |
SMARTi | View protein in SMART SM00554 FAS1, 4 hits |
SUPFAMi | SSF82153 SSF82153, 4 hits |
PROSITEi | View protein in PROSITE PS51041 EMI, 1 hit PS50213 FAS1, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P82198-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLMRLLTL ALALSVGPAG TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA
60 70 80 90 100
VQKVIGTNKK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA
110 120 130 140 150
LPLSNLYETM GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWSS
160 170 180 190 200
LPAEVLDSLV SNVNIELLNA LRYHMVDRRV LTDELKHGMT LTSMYQNSNI
210 220 230 240 250
QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE
260 270 280 290 300
DTFETLRAAV AASGLNTVLE GDGQFTLLAP TNEAFEKIPA ETLNRILGDP
310 320 330 340 350
EALRDLLNNH ILKSAMCAEA IVAGMSMETL GGTTLEVGCS GDKLTINGKA
360 370 380 390 400
VISNKDILAT NGVIHFIDEL LIPDSAKTLL ELAGESDVST AIDILKQAGL
410 420 430 440 450
DTHLSGKEQL TFLAPLNSVF KDGVPRIDAQ MKTLLLNHMV KEQLASKYLY
460 470 480 490 500
SGQTLDTLGG KKLRVFVYRN SLCIENSCIA AHDKRGRFGT LFTMDRMLTP
510 520 530 540 550
PMGTVMDVLK GDNRFSMLVA AIQSAGLMEI LNREGVYTVF APTNEAFQAM
560 570 580 590 600
PPEELNKLLA NAKELTNILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS
610 620 630 640 650
SKNNVVSVNK EPVAETDIMA TNGVVYAINT VLQPPANRPQ ERGDELADSA
660 670 680
LEIFKQASAY SRAAQRSVRL APVYQRLLER MKH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3UXJ2 | Q3UXJ2_MOUSE | Transforming growth factor-beta-ind... | Tgfbi | 651 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19932 mRNA Translation: AAC37658.1 AK084431 mRNA Translation: BAC39181.1 AK142323 mRNA Translation: BAE25032.1 AK151680 mRNA Translation: BAE30605.1 AK152365 mRNA Translation: BAE31155.1 AK155572 mRNA Translation: BAE33330.1 AK155828 mRNA Translation: BAE33452.1 AK170495 mRNA Translation: BAE41834.1 |
CCDSi | CCDS36680.1 |
RefSeqi | NP_033395.1, NM_009369.4 |
Genome annotation databases
Ensembli | ENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493 |
GeneIDi | 21810 |
KEGGi | mmu:21810 |
UCSCi | uc011zae.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19932 mRNA Translation: AAC37658.1 AK084431 mRNA Translation: BAC39181.1 AK142323 mRNA Translation: BAE25032.1 AK151680 mRNA Translation: BAE30605.1 AK152365 mRNA Translation: BAE31155.1 AK155572 mRNA Translation: BAE33330.1 AK155828 mRNA Translation: BAE33452.1 AK170495 mRNA Translation: BAE41834.1 |
CCDSi | CCDS36680.1 |
RefSeqi | NP_033395.1, NM_009369.4 |
3D structure databases
SMRi | P82198 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 204162, 1 interactor |
IntActi | P82198, 1 interactor |
MINTi | P82198 |
STRINGi | 10090.ENSMUSP00000037719 |
PTM databases
iPTMneti | P82198 |
PhosphoSitePlusi | P82198 |
Proteomic databases
CPTACi | non-CPTAC-3690 |
MaxQBi | P82198 |
PaxDbi | P82198 |
PRIDEi | P82198 |
Genome annotation databases
Ensembli | ENSMUST00000045173; ENSMUSP00000037719; ENSMUSG00000035493 |
GeneIDi | 21810 |
KEGGi | mmu:21810 |
UCSCi | uc011zae.1 mouse |
Organism-specific databases
CTDi | 7045 |
MGIi | MGI:99959 Tgfbi |
Phylogenomic databases
eggNOGi | KOG1437 Eukaryota COG2335 LUCA |
GeneTreei | ENSGT00530000063860 |
HOGENOMi | HOG000220865 |
InParanoidi | P82198 |
KOi | K19519 |
OMAi | MGNAKEL |
OrthoDBi | 926852at2759 |
PhylomeDBi | P82198 |
TreeFami | TF316269 |
Miscellaneous databases
ChiTaRSi | Tgfbi mouse |
PROi | PR:P82198 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035493 Expressed in 400 organ(s), highest expression level in cornea |
ExpressionAtlasi | P82198 baseline and differential |
Genevisiblei | P82198 MM |
Family and domain databases
Gene3Di | 2.30.180.10, 4 hits |
InterProi | View protein in InterPro IPR011489 EMI_domain IPR036378 FAS1_dom_sf IPR000782 FAS1_domain IPR032954 TGFBI IPR016666 TGFBI/POSTN |
PANTHERi | PTHR10900:SF82 PTHR10900:SF82, 1 hit |
Pfami | View protein in Pfam PF02469 Fasciclin, 4 hits |
PIRSFi | PIRSF016553 BIGH3_OSF2, 1 hit |
SMARTi | View protein in SMART SM00554 FAS1, 4 hits |
SUPFAMi | SSF82153 SSF82153, 4 hits |
PROSITEi | View protein in PROSITE PS51041 EMI, 1 hit PS50213 FAS1, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BGH3_MOUSE | |
Accessioni | P82198Primary (citable) accession number: P82198 Secondary accession number(s): Q3U9R1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot