UniProtKB - P82140 (DLP2_ORNAN)
Protein
Defensin-like peptide 2/4
Gene
N/A
Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Functioni
Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: UniProtKB
Keywordsi
Molecular function | Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Defensin-like peptide 2/41 PublicationShort name: DLP-2/DLP-41 Publication Alternative name(s): Ornithorhynchus venom defensin-like peptide B1 Publication Short name: OvDLP-B1 Publication |
Organismi | Ornithorhynchus anatinus (Duckbill platypus) |
Taxonomic identifieri | 9258 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Monotremata › Ornithorhynchidae › Ornithorhynchus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000352673 | 23 – 24 | 2 Publications | 2 | |
ChainiPRO_0000079933 | 25 – 66 | Defensin-like peptide 2/42 PublicationsAdd BLAST | 42 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | D-methionine; in form DLP-21 Publication | 1 | |
Disulfide bondi | 33 ↔ 63 | 3 PublicationsImported | ||
Disulfide bondi | 40 ↔ 56 | 3 PublicationsImported | ||
Disulfide bondi | 48 ↔ 64 | 3 PublicationsImported |
Post-translational modificationi
Stereoinversion of L-Met-26 (in DLP-4) to D-Met-26 (in DLP-2).1 Publication
Keywords - PTMi
D-amino acid, Disulfide bondExpressioni
Tissue specificityi
Produced by the crural gland and detected in venom from the spur located on each male hind leg. Is also widely expressed in both male and female tissues, including brain, intestine, kidney, lung, spleen and testis.3 Publications
Gene expression databases
Bgeei | ENSOANG00000001779, Expressed in endometrium and 5 other tissues |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P82140 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P82140 |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | CLU_2830578_0_0_1 |
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR012553, Defensin_3 IPR023355, Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF08131, Defensin_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P82140-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLAYLLLLL VAVLFQAGGG SAKPIMFFEM QACWSHSGVC RDKSERNCKP
60
MAWTYCENRN QKCCEY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q7H017 | A0A6Q7H017_ORNAN | Defensin-like peptide 2/4 | 66 | Annotation score: | |||
A0A6I8P8N5 | A0A6I8P8N5_ORNAN | Defensin-like peptide 2/4 | 49 | Annotation score: |
Genome annotation databases
Ensembli | ENSOANT00000002832; ENSOANP00000002831; ENSOANG00000001780 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Platypus resources |
Protein Spotlight Platypus poison - Issue 29 of December 2002 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D6B | NMR | - | A | 25-66 | [»] | |
1ZUE | NMR | - | A | 25-66 | [»] | |
1ZUF | NMR | - | A | 25-66 | [»] | |
SMRi | P82140 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
Ensembli | ENSOANT00000002832; ENSOANP00000002831; ENSOANG00000001780 |
Phylogenomic databases
HOGENOMi | CLU_2830578_0_0_1 |
Miscellaneous databases
EvolutionaryTracei | P82140 |
Gene expression databases
Bgeei | ENSOANG00000001779, Expressed in endometrium and 5 other tissues |
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR012553, Defensin_3 IPR023355, Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF08131, Defensin_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DLP2_ORNAN | |
Accessioni | P82140Primary (citable) accession number: P82140 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 14, 2008 | |
Last modified: | August 12, 2020 | |
This is version 79 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries