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Protein

Defensin 5

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably contributes to the antimicrobial barrier function of the small intestine.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin 5
Alternative name(s):
Enteric defensin
RD-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000686920 – 58Sequence analysisAdd BLAST39
PeptideiPRO_000000687059 – 93Defensin 5Add BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP82106

Expressioni

Tissue specificityi

Small intestine. Not present in heart, liver, spleen, kidney, large intestine and colon.1 Publication

Inductioni

By hemorrhagic shock.

Structurei

3D structure databases

SMRiP82106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000233351
HOVERGENiHBG011703
PhylomeDBiP82106

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82106-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKLVLLSAL VLLALQVEAE PTPKTDEGTK TDEQPGKEDQ VVSVSIEGQG
60 70 80 90
DPAFQDAVLR DLKCFCRRKS CNWGEGIMGI CKKRYGSPIL CCR
Length:93
Mass (Da):10,242
Last modified:November 1, 1999 - v1
Checksum:i7D9A71CEBFC42431
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115768 mRNA Translation: AAD22963.1
UniGeneiRn.139152

Genome annotation databases

UCSCiRGD:1304852 rat

Similar proteinsi

Entry informationi

Entry nameiDEF5_RAT
AccessioniPrimary (citable) accession number: P82106
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: May 10, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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