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Protein

TATA element modulatory factor

Gene

TMF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).4 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription coregulator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
TATA element modulatory factor
Short name:
TMF
Alternative name(s):
Androgen receptor coactivator 160 kDa protein
Androgen receptor-associated protein of 160 kDa
Gene namesi
Name:TMF1
Synonyms:ARA160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144747.14
HGNCiHGNC:11870 TMF1
MIMi601126 gene
neXtProtiNX_P82094

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi333 – 335SLD → AAA: Strongly reduced the ubiquitination directing activity of the protein. 1 Publication3

Organism-specific databases

DisGeNETi7110
OpenTargetsiENSG00000144747
PharmGKBiPA36571

Polymorphism and mutation databases

BioMutaiTMF1
DMDMi218511858

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725891 – 1093TATA element modulatory factorAdd BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei413PhosphoserineBy similarity1
Modified residuei542PhosphoserineCombined sources1
Modified residuei925PhosphoserineCombined sources1
Modified residuei928PhosphoserineBy similarity1
Modified residuei929PhosphothreonineBy similarity1
Modified residuei933PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FER.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP82094
MaxQBiP82094
PaxDbiP82094
PeptideAtlasiP82094
PRIDEiP82094
ProteomicsDBi57702
57703 [P82094-2]

PTM databases

iPTMnetiP82094
PhosphoSitePlusiP82094

Expressioni

Inductioni

Down-regulated in malignant brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000144747 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_TMF1
ExpressionAtlasiP82094 baseline and differential
GenevisibleiP82094 HS

Organism-specific databases

HPAiHPA008729

Interactioni

Subunit structurei

Interacts with TRNP1; may regulate TRNP1 proteasomal degradation (By similarity). Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NR3C1P041503EBI-949763,EBI-493507

Protein-protein interaction databases

BioGridi112965, 16 interactors
DIPiDIP-5933N
IntActiP82094, 16 interactors
MINTiP82094
STRINGi9606.ENSP00000381567

Structurei

3D structure databases

ProteinModelPortaliP82094
SMRiP82094
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni333 – 342Interaction with Elongin BC complex10

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili439 – 922Sequence analysisAdd BLAST484
Coiled coili984 – 1092Sequence analysisAdd BLAST109

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGA0 Eukaryota
ENOG410YE9Z LUCA
GeneTreeiENSGT00390000010697
HOGENOMiHOG000154639
HOVERGENiHBG016599
InParanoidiP82094
KOiK20286
OMAiGEISHLQ
OrthoDBiEOG091G01F7
PhylomeDBiP82094
TreeFamiTF329420

Family and domain databases

InterProiView protein in InterPro
IPR022092 TMF_DNA-bd
IPR022091 TMF_TATA-bd
PfamiView protein in Pfam
PF12329 TMF_DNA_bd, 1 hit
PF12325 TMF_TATA_bd, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P82094-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS
60 70 80 90 100
SPVSGGWDTS TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF
110 120 130 140 150
LSPTDVQTIQ KSPVVSKPPA KSQRPEEEVK SSLHESLHIG QSRTPETTES
160 170 180 190 200
QVKDSSLCVS GETLAAGTSS PKTEGKHEET VNKESDMKVP TVSLKVSESV
210 220 230 240 250
IDVKTTMESI SNTSTQSLTA ETKDIALEPK EQKHEDRQSN TPSPPVSTFS
260 270 280 290 300
SGTSTTSDIE VLDHESVISE SSASSRQETT DSKSSLHLMQ TSFQLLSASA
310 320 330 340 350
CPEYNRLDDF QKLTESCCSS DAFERIDSFS VQSLDSRSVS EINSDDELSG
360 370 380 390 400
KGYALVPIIV NSSTPKSKTV ESAEGKSEEV NETLVIPTEE AEMEESGRSA
410 420 430 440 450
TPVNCEQPDI LVSSTPINEG QTVLDKVAEQ CEPAESQPEA LSEKEDVCKT
460 470 480 490 500
VEFLNEKLEK REAQLLSLSK EKALLEEAFD NLKDEMFRVK EESSSISSLK
510 520 530 540 550
DEFTQRIAEA EKKVQLACKE RDAAKKEIKN IKEELATRLN SSETADLLKE
560 570 580 590 600
KDEQIRGLME EGEKLSKQQL HNSNIIKKLR AKDKENENMV AKLNKKVKEL
610 620 630 640 650
EEELQHLKQV LDGKEEVEKQ HRENIKKLNS MVERQEKDLG RLQVDMDELE
660 670 680 690 700
EKNRSIQAAL DSAYKELTDL HKANAAKDSE AQEAALSREM KAKEELSAAL
710 720 730 740 750
EKAQEEARQQ QETLAIQVGD LRLALQRTEQ AAARKEDYLR HEIGELQQRL
760 770 780 790 800
QEAENRNQEL SQSVSSTTRP LLRQIENLQA TLGSQTSSWE KLEKNLSDRL
810 820 830 840 850
GESQTLLAAA VERERAATEE LLANKIQMSS MESQNSLLRQ ENSRFQAQLE
860 870 880 890 900
SEKNRLCKLE DENNRYQVEL ENLKDEYVRT LEETRKEKTL LNSQLEMERM
910 920 930 940 950
KVEQERKKAI FTQETIKEKE RKPFSVSSTP TMSRSSSISG VDMAGLQTSF
960 970 980 990 1000
LSQDESHDHS FGPMPISANG SNLYDAVRMG AGSSIIENLQ SQLKLREGEI
1010 1020 1030 1040 1050
THLQLEIGNL EKTRSIMAEE LVKLTNQNDE LEEKVKEIPK LRTQLRDLDQ
1060 1070 1080 1090
RYNTILQMYG EKAEEAEELR LDLEDVKNMY KTQIDELLRQ SLS
Length:1,093
Mass (Da):122,842
Last modified:December 16, 2008 - v2
Checksum:i566BBE3EC36EF11C
GO
Isoform 2 (identifier: P82094-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: K → KVTL

Show »
Length:1,096
Mass (Da):123,155
Checksum:iA539A619EE47842D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF45F8WF45_HUMAN
TATA element modulatory factor
TMF1
775Annotation score:
A0A2R8Y7M0A0A2R8Y7M0_HUMAN
TATA element modulatory factor
TMF1
985Annotation score:

Sequence cautioni

The sequence AAD54608 differs from that shown. Reason: Frameshift at positions 969, 971, 975 and 985.Curated
The sequence BAD92346 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051439430Q → E. Corresponds to variant dbSNP:rs35447207Ensembl.1
Natural variantiVAR_051440448C → Y. Corresponds to variant dbSNP:rs34428015Ensembl.1
Natural variantiVAR_051441682Q → R. Corresponds to variant dbSNP:rs3736422Ensembl.1
Natural variantiVAR_024284798D → H. Corresponds to variant dbSNP:rs1532918Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037411449K → KVTL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01042 mRNA Translation: AAD54608.1 Frameshift.
AB209109 mRNA Translation: BAD92346.1 Different initiation.
AC109587 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65468.1
BC117418 mRNA Translation: AAI17419.1
BC126123 mRNA Translation: AAI26124.1
BC143840 mRNA Translation: AAI43841.1
CCDSiCCDS43105.1 [P82094-1]
CCDS87105.1 [P82094-2]
PIRiA47212
RefSeqiNP_009045.2, NM_007114.2 [P82094-1]
XP_011532358.1, XM_011534056.2
UniGeneiHs.267632

Genome annotation databases

EnsembliENST00000398559; ENSP00000381567; ENSG00000144747 [P82094-1]
ENST00000646708; ENSP00000494067; ENSG00000144747 [P82094-2]
GeneIDi7110
KEGGihsa:7110
UCSCiuc003dnn.4 human [P82094-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01042 mRNA Translation: AAD54608.1 Frameshift.
AB209109 mRNA Translation: BAD92346.1 Different initiation.
AC109587 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65468.1
BC117418 mRNA Translation: AAI17419.1
BC126123 mRNA Translation: AAI26124.1
BC143840 mRNA Translation: AAI43841.1
CCDSiCCDS43105.1 [P82094-1]
CCDS87105.1 [P82094-2]
PIRiA47212
RefSeqiNP_009045.2, NM_007114.2 [P82094-1]
XP_011532358.1, XM_011534056.2
UniGeneiHs.267632

3D structure databases

ProteinModelPortaliP82094
SMRiP82094
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112965, 16 interactors
DIPiDIP-5933N
IntActiP82094, 16 interactors
MINTiP82094
STRINGi9606.ENSP00000381567

PTM databases

iPTMnetiP82094
PhosphoSitePlusiP82094

Polymorphism and mutation databases

BioMutaiTMF1
DMDMi218511858

Proteomic databases

EPDiP82094
MaxQBiP82094
PaxDbiP82094
PeptideAtlasiP82094
PRIDEiP82094
ProteomicsDBi57702
57703 [P82094-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398559; ENSP00000381567; ENSG00000144747 [P82094-1]
ENST00000646708; ENSP00000494067; ENSG00000144747 [P82094-2]
GeneIDi7110
KEGGihsa:7110
UCSCiuc003dnn.4 human [P82094-1]

Organism-specific databases

CTDi7110
DisGeNETi7110
EuPathDBiHostDB:ENSG00000144747.14
GeneCardsiTMF1
HGNCiHGNC:11870 TMF1
HPAiHPA008729
MIMi601126 gene
neXtProtiNX_P82094
OpenTargetsiENSG00000144747
PharmGKBiPA36571
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGA0 Eukaryota
ENOG410YE9Z LUCA
GeneTreeiENSGT00390000010697
HOGENOMiHOG000154639
HOVERGENiHBG016599
InParanoidiP82094
KOiK20286
OMAiGEISHLQ
OrthoDBiEOG091G01F7
PhylomeDBiP82094
TreeFamiTF329420

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiTMF1 human
GeneWikiiTMF1
GenomeRNAii7110
PROiPR:P82094
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144747 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_TMF1
ExpressionAtlasiP82094 baseline and differential
GenevisibleiP82094 HS

Family and domain databases

InterProiView protein in InterPro
IPR022092 TMF_DNA-bd
IPR022091 TMF_TATA-bd
PfamiView protein in Pfam
PF12329 TMF_DNA_bd, 1 hit
PF12325 TMF_TATA_bd, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMF1_HUMAN
AccessioniPrimary (citable) accession number: P82094
Secondary accession number(s): B7ZLJ2, Q17R87, Q59GK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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