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UniProtKB - P81909 (OR22A_DROME)

Entry version 157 (10 Feb 2021)
Sequence version 1 (01 Aug 1999)
Previous versions | rss
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Protein

Odorant receptor 22a

Gene

Or22a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide.9 Publications

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor, Transducer
Biological processOlfaction, Sensory transduction

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.69.1.1, the heteromeric odorant receptor channel (horc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Odorant receptor 22a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Or22a
Synonyms:AN11, DOR22A.1, dor53, Or22A.1
ORF Names:CG12193
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0026398, Or22a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 86ExtracellularSequence analysisAdd BLAST16
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 136CytoplasmicSequence analysisAdd BLAST29
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 182ExtracellularSequence analysisAdd BLAST25
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini204 – 263CytoplasmicSequence analysisAdd BLAST60
Transmembranei264 – 280Helical; Name=5Sequence analysisAdd BLAST17
Topological domaini281 – 286ExtracellularSequence analysis6
Transmembranei287 – 304Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini305 – 356CytoplasmicSequence analysisAdd BLAST52
Transmembranei357 – 377Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini378 – 397ExtracellularSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001742321 – 397Odorant receptor 22aAdd BLAST397

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P81909

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed with Orco in 17-20 sensory neurons on the medial-proximal edge of the antenna. Expressed in the ab3A neuron which responds to ethyl butyrate.7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0026398, Expressed in antenna and 11 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P81909, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P81909, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Orco, via conserved C-terminal cytoplasmic loops. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.

Interacts with snmp1.

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		59579, 5 interactors

Database of interacting proteins

More...DIPi		DIP-20484N

Protein interaction database and analysis system

More...IntActi		P81909, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0077541

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R7K0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00540000073151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033399_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P81909

Identification of Orthologs from Complete Genome Data

More...OMAi		MARCHIC

Database of Orthologous Groups

More...OrthoDBi		745380at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P81909

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004117, 7tm6_olfct_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR21137, PTHR21137, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02949, 7tm_6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P81909-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSKFFPHIK EKPLSERVKS RDAFIYLDRV MWSFGWTEPE NKRWILPYKL 
        60         70         80         90        100
WLAFVNIVML ILLPISISIE YLHRFKTFSA GEFLSSLEIG VNMYGSSFKC 
       110        120        130        140        150
AFTLIGFKKR QEAKVLLDQL DKRCLSDKER STVHRYVAMG NFFDILYHIF 
       160        170        180        190        200
YSTFVVMNFP YFLLERRHAW RMYFPYIDSD EQFYISSIAE CFLMTEAIYM 
       210        220        230        240        250
DLCTDVCPLI SMLMARCHIS LLKQRLRNLR SKPGRTEDEY LEELTECIRD 
       260        270        280        290        300
HRLLLDYVDA LRPVFSGTIF VQFLLIGTVL GLSMINLMFF STFWTGVATC 
       310        320        330        340        350
LFMFDVSMET FPFCYLCNMI IDDCQEMSNC LFQSDWTSAD RRYKSTLVYF 
       360        370        380        390 
LHNLQQPITL TAGGVFPISM QTNLAMVKLA FSVVTVIKQF NLAERFQ
Length:397
Mass (Da):46,754
Last modified:August 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9D20EF06E69E883
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256D → SIPFLFINGLFLFLS (PubMed:10458908).Curated1
Sequence conflicti376 – 397MVKLA…AERFQ → VGVNILDISLILHLF (PubMed:10458908).CuratedAdd BLAST22

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti8H → Y in strain: MA74. 1 Publication1
Natural varianti59M → I in strain: NC1b. 1 Publication1
Natural varianti67I → M in strain: MA43 and MA74. 1 Publication1
Natural varianti93M → V in strain: NC1b and NC97a. 1 Publication1
Natural varianti100C → S in strain: CN1, CN13, CN18, CN21, CN29, CN45, CN51, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35, LA4, MA21, MA24, NC1b, NC100b, NC37a, NC84a, NC89a and NC97a. 1 Publication1
Natural varianti102F → L in strain: NC97a. 1 Publication1
Natural varianti196E → A in strain: CN1, CN13, CN18, CN21, CN28, CN29, CN45, CN51, LA120, LA128, LA13, LA15, LA25, LA3, LA32, LA34, LA35, LA4, LA6, LA9, MA21, MA24, NC1b, NC100b, NC16a, NC37a, NC84a, NC89a and NC97a. 1 Publication1
Natural varianti201D → E in strain: NC1b and NC97a. 1 Publication1
Natural varianti220S → N in strain: CN14. 1 Publication1
Natural varianti292T → S in strain: CN13. 1 Publication1
Natural varianti328S → A in strain: LA6. 1 Publication1
Natural varianti329N → D in strain: LA6. 1 Publication1
Natural varianti330C → S in strain: LA6. 1 Publication1
Natural varianti359T → I in strain: LA6. 1 Publication1
Natural varianti375A → N in strain: LA6. 1 Publication1
Natural varianti382S → T in strain: LA6. 1 Publication1
Natural varianti385T → A in strain: NC1b and NC97a. 1 Publication1
Natural varianti386V → I in strain: LA6. 1 Publication1
Natural varianti387I → V in strain: LA6. 1 Publication1
Natural varianti395R → K in strain: LA6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FM212142 Genomic DNA Translation: CAR79041.1
FM212143 Genomic DNA Translation: CAR79043.1
FM212144 Genomic DNA Translation: CAR79045.1
FM212145 Genomic DNA Translation: CAR79047.1
FM212146 Genomic DNA Translation: CAR79049.1
FM212147 Genomic DNA Translation: CAR79051.1
FM212148 Genomic DNA Translation: CAR79053.1
FM212149 Genomic DNA Translation: CAR79055.1
FM212150 Genomic DNA Translation: CAR79057.1
FM212151 Genomic DNA Translation: CAR79059.1
FM212152 Genomic DNA Translation: CAR79061.1
FM212153 Genomic DNA Translation: CAR79063.1
FM212154 Genomic DNA Translation: CAR79065.1
FM212155 Genomic DNA Translation: CAR79067.1
FM212156 Genomic DNA Translation: CAR79069.1
FM212157 Genomic DNA Translation: CAR79071.1
FM212158 Genomic DNA Translation: CAR79073.1
FM212159 Genomic DNA Translation: CAR79075.1
FM212160 Genomic DNA Translation: CAR79077.1
FM212161 Genomic DNA Translation: CAR79079.1
FM212162 Genomic DNA Translation: CAR79081.1
FM212163 Genomic DNA Translation: CAR79083.1
FM212164 Genomic DNA Translation: CAR79085.1
FM212165 Genomic DNA Translation: CAR79087.1
FM212166 Genomic DNA Translation: CAR79089.1
FM212167 Genomic DNA Translation: CAR79091.1
FM212168 Genomic DNA Translation: CAR79093.1
FM212169 Genomic DNA Translation: CAR79095.1
FM212170 Genomic DNA Translation: CAR79097.1
FM212171 Genomic DNA Translation: CAR79099.1
FM212172 Genomic DNA Translation: CAR79101.1
FM212173 Genomic DNA Translation: CAR79103.1
FM212174 Genomic DNA Translation: CAR79105.1
FM212175 Genomic DNA Translation: CAR79107.1
FM212176 Genomic DNA Translation: CAR79109.1
FM212177 Genomic DNA Translation: CAR79111.1
FM212178 Genomic DNA Translation: CAR79113.1
FM212204 Genomic DNA Translation: CAR79364.1
AE014134 Genomic DNA Translation: AAF51364.1
AF127923 mRNA Translation: AAD26358.2

NCBI Reference Sequences

More...RefSeqi		NP_523453.1, NM_078729.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0077873; FBpp0077541; FBgn0026398

Database of genes from NCBI RefSeq genomes

More...GeneIDi		33335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12193

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM212142 Genomic DNA Translation: CAR79041.1
FM212143 Genomic DNA Translation: CAR79043.1
FM212144 Genomic DNA Translation: CAR79045.1
FM212145 Genomic DNA Translation: CAR79047.1
FM212146 Genomic DNA Translation: CAR79049.1
FM212147 Genomic DNA Translation: CAR79051.1
FM212148 Genomic DNA Translation: CAR79053.1
FM212149 Genomic DNA Translation: CAR79055.1
FM212150 Genomic DNA Translation: CAR79057.1
FM212151 Genomic DNA Translation: CAR79059.1
FM212152 Genomic DNA Translation: CAR79061.1
FM212153 Genomic DNA Translation: CAR79063.1
FM212154 Genomic DNA Translation: CAR79065.1
FM212155 Genomic DNA Translation: CAR79067.1
FM212156 Genomic DNA Translation: CAR79069.1
FM212157 Genomic DNA Translation: CAR79071.1
FM212158 Genomic DNA Translation: CAR79073.1
FM212159 Genomic DNA Translation: CAR79075.1
FM212160 Genomic DNA Translation: CAR79077.1
FM212161 Genomic DNA Translation: CAR79079.1
FM212162 Genomic DNA Translation: CAR79081.1
FM212163 Genomic DNA Translation: CAR79083.1
FM212164 Genomic DNA Translation: CAR79085.1
FM212165 Genomic DNA Translation: CAR79087.1
FM212166 Genomic DNA Translation: CAR79089.1
FM212167 Genomic DNA Translation: CAR79091.1
FM212168 Genomic DNA Translation: CAR79093.1
FM212169 Genomic DNA Translation: CAR79095.1
FM212170 Genomic DNA Translation: CAR79097.1
FM212171 Genomic DNA Translation: CAR79099.1
FM212172 Genomic DNA Translation: CAR79101.1
FM212173 Genomic DNA Translation: CAR79103.1
FM212174 Genomic DNA Translation: CAR79105.1
FM212175 Genomic DNA Translation: CAR79107.1
FM212176 Genomic DNA Translation: CAR79109.1
FM212177 Genomic DNA Translation: CAR79111.1
FM212178 Genomic DNA Translation: CAR79113.1
FM212204 Genomic DNA Translation: CAR79364.1
AE014134 Genomic DNA Translation: AAF51364.1
AF127923 mRNA Translation: AAD26358.2
RefSeqiNP_523453.1, NM_078729.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi59579, 5 interactors
DIPiDIP-20484N
IntActiP81909, 3 interactors
STRINGi7227.FBpp0077541

Protein family/group databases

TCDBi1.A.69.1.1, the heteromeric odorant receptor channel (horc) family

Proteomic databases

PaxDbiP81909

Genome annotation databases

EnsemblMetazoaiFBtr0077873; FBpp0077541; FBgn0026398
GeneIDi33335
KEGGidme:Dmel_CG12193

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		33335
FlyBaseiFBgn0026398, Or22a

Phylogenomic databases

eggNOGiENOG502R7K0, Eukaryota
GeneTreeiENSGT00540000073151
HOGENOMiCLU_033399_8_0_1
InParanoidiP81909
OMAiMARCHIC
OrthoDBi745380at2759
PhylomeDBiP81909

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		33335, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		33335

Protein Ontology

More...PROi		PR:P81909

Gene expression databases

BgeeiFBgn0026398, Expressed in antenna and 11 other tissues
ExpressionAtlasiP81909, baseline and differential
GenevisibleiP81909, DM

Family and domain databases

InterProiView protein in InterPro
IPR004117, 7tm6_olfct_rcpt
PANTHERiPTHR21137, PTHR21137, 1 hit
PfamiView protein in Pfam
PF02949, 7tm_6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOR22A_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81909
Secondary accession number(s): B7VC05
, B7VC07, B7VC09, B7VC11, B7VC21, B7VC27, B7VC29, B7VC75, B7VC77, B7VCA5, Q9U6X7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1999
Last modified: February 10, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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