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Protein

Cholinesterase

Gene

BCHE

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity).By similarity

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei198Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei325Charge relay systemBy similarity1
Active sitei438Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERihorse-BCHE BCHE
MEROPSiS09.980

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
EQ-BCHE
Pseudocholinesterase
Gene namesi
Name:BCHE
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5763

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702851 – 574CholinesteraseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagine1
Disulfide bondi65 ↔ 92By similarity
Glycosylationi106N-linked (GlcNAc...) asparagine1
Modified residuei198PhosphoserineBy similarity1
Glycosylationi241N-linked (GlcNAc...) asparagine1
Disulfide bondi252 ↔ 263By similarity
Glycosylationi256N-linked (GlcNAc...) asparagine1
Glycosylationi341N-linked (GlcNAc...) asparagine1
Disulfide bondi400 ↔ 519By similarity
Glycosylationi455N-linked (GlcNAc...) asparagine1
Glycosylationi481N-linked (GlcNAc...) asparagine1
Glycosylationi486N-linked (GlcNAc...) asparagine1
Disulfide bondi571InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP81908
PRIDEiP81908

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Present in most cells except erythrocytes.1 Publication

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000166

Chemistry databases

BindingDBiP81908

Structurei

3D structure databases

ProteinModelPortaliP81908
SMRiP81908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 117Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
InParanoidiP81908

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

P81908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EEDIIITTKN GKVRGMNLPV LGGTVTAFLG IPYAQPPLGR LRFKKPQSLT
60 70 80 90 100
KWSNIWNATK YANSCYQNTD QSFPGFLGSE MWNPNTELSE DCLYLNVWIP
110 120 130 140 150
APKPKNATVM IWIYGGGFQT GTSSLPVYDG KFLARVERVI VVSMNYRVGA
160 170 180 190 200
LGFLALSENP EAPGNMGLFD QQLALQWVQK NIAAFGGNPR SVTLFGESAG
210 220 230 240 250
AASVSLHLLS PRSQPLFTRA ILQSGSSNAP WAVTSLYEAR NRTLTLAKRM
260 270 280 290 300
GCSRDNETEM IKCLRDKDPQ EILLNEVFVV PYDTLLSVNF GPTVDGDFLT
310 320 330 340 350
DMPDTLLQLG QFKRTQILVG VNKDEGTAFL VYGAPGFSKD NNSIITRKEF
360 370 380 390 400
QEGLKIFFPR VSEFGRESIL FHYMDWLDDQ RAENYREALD DVVGDYNIIC
410 420 430 440 450
PALEFTRKFS ELGNDAFFYY FEHRSTKLPW PEWMGVMHGY EIEFVFGLPL
460 470 480 490 500
ERRVNYTRAE EILSRSIMKR WANFAKYGNP NGTQNNSTRW PVFKSTEQKY
510 520 530 540 550
LTLNTESPKV YTKLRAQQCR FWTLFFPKVL ELTGNIDEAE REWKAGFHRW
560 570
NNYMMDWKNQ FNDYTSKKES CSDF
Length:574
Mass (Da):65,642
Last modified:May 1, 2000 - v1
Checksum:i07755EE9FB9CB33E
GO

Sequence databases

UniGeneiEca.13015

Similar proteinsi

Cross-referencesi

Sequence databases

UniGeneiEca.13015

3D structure databases

ProteinModelPortaliP81908
SMRiP81908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000166

Chemistry databases

BindingDBiP81908
ChEMBLiCHEMBL5763

Protein family/group databases

ESTHERihorse-BCHE BCHE
MEROPSiS09.980

Proteomic databases

PaxDbiP81908
PRIDEiP81908

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
InParanoidiP81908

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHLE_HORSE
AccessioniPrimary (citable) accession number: P81908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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