Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disintegrin EMF10B

Gene
N/A
Organism
Eristicophis macmahoni (Leaf-nosed viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1). Partially inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM. Weakly inhibits ADP-induced platelet aggregation.1 Publication

Miscellaneous

The disintegrin belongs to the dimeric disintegrin subfamily.

Caution

Eristocophin II appears to represent degradation product of EMF10B.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin EMF10B
Short name:
EMF-10B
Alternative name(s):
Eristocophin II
Platelet aggregation activation inhibitor
OrganismiEristicophis macmahoni (Leaf-nosed viper)
Taxonomic identifieri110227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEristicophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018041 – 68Disintegrin EMF10BAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 33PROSITE-ProRule annotation1 Publication
Disulfide bondi11Interchain (with C-8 in EMF10A)PROSITE-ProRule annotation1 Publication
Disulfide bondi16Interchain (with C-13 in EMF10A)PROSITE-ProRule annotation1 Publication
Disulfide bondi24 ↔ 30PROSITE-ProRule annotation1 Publication
Disulfide bondi29 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi42 ↔ 61PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with EMF10A; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81743
SMRiP81743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 68DisintegrinPROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 48Cell attachment site; atypical (MGD)3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P81743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ELLQNSGNPC CDPVTCKPRR GEHCVSGPCC DNCKFLNAGT VCWPAMGDWN
60
DDYCTGISSD CPRNPVFK
Length:68
Mass (Da):7,427
Last modified:May 30, 2000 - v1
Checksum:iE63FEE61BCE74220
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 8NSGN → ESAG AA sequence (PubMed:1494485).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35F → K2 Publications1
Natural varianti65 – 68Missing . 4

Similar proteinsi

Entry informationi

Entry nameiVM2AB_ERIMA
AccessioniPrimary (citable) accession number: P81743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health